Prof. Dr. rer. nat. Oliver Seitz

Prof. Seitz entwickelt chemische Methoden zur Synthese und Modifizierung von Peptiden und Proteinen, insbesondere durch native chemische Ligation und verwandte Verknüpfungstechniken. Sein aktueller Fokus liegt auf der Herstellung komplexer, post-translational modifizierter Peptide (glycosyliert, phosphoryliert) und deren Einsatz als Sonden zur Untersuchung von Zellober­flächen-Rezeptoren sowie zur Entwicklung biospezifischer Wirkstoffe für die Krebstherapie. Die Methoden ermöglichen es, Peptide und Proteine präzise zu konstruieren und zu funktionalisieren — ein Schlüsselproblem für die pharmazeutische Wirkstoffentwicklung, die Diagnostik und die Grundlagenforschung in Zellbiologie. Relevant sind die Arbeiten für die Pharmazie, Biotechnologie und medizinische Diagnostik.

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• Synthese und Modifizierung von Biopolymeren

  Quelle ↗

  Zeitraum: 08/2003 - 07/2008 Projektleitung: Prof. Dr. rer. nat. Oliver Seitz

• Steuerung und Katalyse der chemischen Verknüpfung von PNA-Konjugaten durch Oligonucleotid-Template I

  Quelle ↗

  Förderer: DFG Sachbeihilfe Zeitraum: 09/2003 - 02/2006 Projektleitung: Prof. Dr. rer. nat. Oliver Seitz

• Nucleinsäurehybridisierungsgesteuerte Kontrolle der Peptidkonformation als Werkzeug zum Studium der biologischen Signaltransduktion

  Quelle ↗

  Förderer: Volkswagen Stiftung Zeitraum: 11/2003 - 11/2006 Projektleitung: Prof. Dr. rer. nat. Oliver Seitz

• Multivalency as a Chemical Organization and Action Principle

  2012

  Angewandte Chemie International Edition · DOI

  Multivalent interactions can be applied universally for a targeted strengthening of an interaction between different interfaces or molecules. The binding partners form cooperative, multiple receptor-ligand interactions that are based on individually weak, noncovalent bonds and are thus generally reversible. Hence, multi- and polyvalent interactions play a decisive role in biological systems for recognition, adhesion, and signal processes. The scientific and practical realization of this principle will be demonstrated by the development of simple artificial and theoretical models, from natural systems to functional, application-oriented systems. In a systematic review of scaffold architectures, the underlying effects and control options will be demonstrated, and suggestions will be given for designing effective multivalent binding systems, as well as for polyvalent therapeutics.

• Hydrothermal Synthesis of Graphene-TiO₂ Nanotube Composites with Enhanced Photocatalytic Activity

  2012

  ACS Catalysis · DOI

  In this study, TiO 2 nanotube (TNT)/reduced graphene oxide (hGO) composites were prepared by an alkaline hydrothermal process. This was achieved by decorating graphene oxide (GO) layers with commercially available TiO 2 nanoparticles (P90) followed by hydrothermal synthesis, which converts the TiO 2 nanoparticles to small diameter (∼9 nm) TNTs on the hGO surface. The alkaline medium used to synthesize the TNTs simultaneously converts GO to deoxygenated graphene oxide (hGO). Compared to GO, the hGO has a ∼70% reduction of oxygenated species after alkaline hydrothermal treatment. The graphene nature of hGO in the composites was confirmed by X-ray diffraction (XRD), Raman, FTIR, and X-ray photoelectron spectroscopy (XPS) analysis. The photocatalytic performance of the hGO-TNT composites was evaluated for the photodegradation of malachite green. It was found that the ratio of hGO to TNT in the composites significantly affects the photocatalytic activity. Higher amounts of hGO in hGO-TNT composites showed lower photocatalytic activity than pure TNTs. The composite with 10% hGO showed the highest photocatalytic activity, with a 3-fold enhancement in photocatalytic efficiency over pure TNTs. It is expected that the synthesis of “high surface area-small diameter” TiO 2 nanotubes and simultaneous conversion of GO to graphene like hGO “without using strong reducing agents” could be a promising strategy for preparing other types of carbon based TiO 2 nanotube composite photocatalysts.