Dr. rer. nat. Rosa Grützmann
Profil
Forschungsthemen1
Neurokognitive Adaptivität und deren Beeinflussung durch kognitives Training bei Patienten mit Zwangsstörung
Quelle ↗Förderer: DFG Sachbeihilfe Zeitraum: 04/2018 - 11/2022 Projektleitung: Dr. rer. nat. Rosa Grützmann
Mögliche Industrie-Partner10
Stand: 26.4.2026, 19:48:44 (Top-K=20, Min-Cosine=0.4)
- 36 Treffer55.6%
- FOR 5177/2: Korrelation der Leistungsfähigkeit der Lendenwirbelsäule mit klinischen Outcomes nach einer gezielten Behandlung bei Patienten mit unteren Rückenschmerzen (TP 04)P55.6%
- FOR 5177/2: Korrelation der Leistungsfähigkeit der Lendenwirbelsäule mit klinischen Outcomes nach einer gezielten Behandlung bei Patienten mit unteren Rückenschmerzen (TP 04)
- 43 Treffer54.9%
- DFG-Sachbeihilfe: Aufmerksamkeit und sensorische Integration im aktiven Sehen von bewegten ObjektenT54.9%
- SFB 1315/2: Mechanismen und Störungen der Gedächtniskonsolidierung: Von Synapsen zur SystemebeneP51.8%
- DFG-Sachbeihilfe: Aufmerksamkeit und sensorische Integration im aktiven Sehen von bewegten Objekten
- 21 Treffer54.0%
- Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other StrategiesP54.0%
- Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other Strategies
- 22 Treffer54.0%
- Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other StrategiesP54.0%
- Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other Strategies
- 21 Treffer54.0%
- Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other StrategiesP54.0%
- Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other Strategies
- 1 Treffer53.7%
- Zuwendung im Rahmen des Programms „exist – Existenzgründungen aus der Wissenschaft“ aus dem Bundeshaushalt, Einzelplan 09, Kapitel 02, Titel 68607, Haushaltsjahr 2026, sowie aus Mitteln des Europäischen Strukturfonds (hier Euro-päischer Sozialfonds Plus – ESF Plus) Förderperiode 2021-2027 – Kofinanzierung für das Vorhaben: „exist Women“T53.7%
- Zuwendung im Rahmen des Programms „exist – Existenzgründungen aus der Wissenschaft“ aus dem Bundeshaushalt, Einzelplan 09, Kapitel 02, Titel 68607, Haushaltsjahr 2026, sowie aus Mitteln des Europäischen Strukturfonds (hier Euro-päischer Sozialfonds Plus – ESF Plus) Förderperiode 2021-2027 – Kofinanzierung für das Vorhaben: „exist Women“
- 35 Treffer53.7%
- Promoting Deaf and Hard of Hearing Children's Theory of Mind and Emotion UnderstandingP53.7%
- Promoting Deaf and Hard of Hearing Children's Theory of Mind and Emotion Understanding
- Promoting Deaf and Hard of Hearing Children's Theory of Mind and Emotion UnderstandingP53.7%
- Promoting Deaf and Hard of Hearing Children's Theory of Mind and Emotion Understanding
- 32 Treffer53.7%
- Promoting Deaf and Hard of Hearing Children's Theory of Mind and Emotion UnderstandingP53.7%
- Promoting Deaf and Hard of Hearing Children's Theory of Mind and Emotion Understanding
- 31 Treffer53.7%
- Promoting Deaf and Hard of Hearing Children's Theory of Mind and Emotion UnderstandingP53.7%
- Promoting Deaf and Hard of Hearing Children's Theory of Mind and Emotion Understanding
Publikationen25
Top 25 nach Zitationen — Quelle: OpenAlex (BAAI/bge-m3 embedded für Matching).
Psychological Medicine · 127 Zitationen · DOI
Alterations in neural error-signals in unaffected first-degree relatives with a family history of OCD, anxiety, or SUD support the utility of the ERN as a transdiagnostic endophenotype. Reduced neural error-signals may indicate vulnerability for under-controlled behavior and risk for substance use, whereas a harm- or error-avoidant response style and vulnerability for OCD and anxiety appears to be associated with increased ERN. This adds to findings suggesting a common neurobiological substrate across psychiatric disorders involving the anterior cingulate cortex and deficits in cognitive control.
Presupplementary Motor Area Contributes to Altered Error Monitoring in Obsessive-Compulsive Disorder
2014Biological Psychiatry · 80 Zitationen · DOI
Biological Psychology · 56 Zitationen · DOI
NeuroImage Clinical · 54 Zitationen · DOI
Previous research in patients with obsessive-compulsive disorder (OCD) has indicated performance decrements in working memory (WM) and response inhibition. However, underlying neural mechanisms of WM deficits are not well understood to date, and empirical evidence for a proposed conceptual link to inhibition deficits is missing. We investigated WM performance in a numeric n-back task with four WM load conditions during functional Magnetic Resonance Imaging (fMRI) in 51 patients with OCD and 49 healthy control participants who were matched for age, sex, and education. Additionally, a stop signal task was performed outside the MRI scanner in a subsample. On the behavioral level, a significant WM load by group interaction was found for both accuracy (p < 0.02) and reaction time measures (p < 0.03), indicating increased reaction times as well as reduced accuracy specifically at high WM load (3-back) in patients with OCD. Whole-brain analyses of fMRI-data identified neural correlates of a load-dependent WM decrement in OCD in the supplementary motor area (SMA) and the inferior parietal lobule (IPL). Within the OCD sample, SMA-activity as well as n-back performance were correlated with stop signal task performance. Results from behavioral and fMRI-analyses indicate a reduced WM load-dependent modulation of neural activity in OCD and suggest a common neural mechanism for inhibitory dysfunction and WM decrements in OCD.
Cognitive Affective & Behavioral Neuroscience · 51 Zitationen · DOI
Acta Psychiatrica Scandinavica · 43 Zitationen · DOI
Our results provide further evidence for a diathesis-stress model of OCD. While patients and unaffected relatives share elevated levels of harm avoidance, supporting the role of harm avoidance as an endophenotype of OCD, a heightened severity of childhood adversity was only observed in patients. The assumed biological underpinnings of these findings are discussed.
Psychophysiology · 37 Zitationen · DOI
The present study investigated the modulation of the N2 and the correct-related negativity (CRN) by conflict frequency. Conflict costs, as measured by reaction times and error rate, were reduced with increasing conflict frequency, indicating improved conflict resolution. N2 amplitudes in incompatible trials increased with higher conflict frequency, while postresponse CRN amplitudes decreased. In concert with behavioral findings of reduced conflict costs and greater interference suppression, the increase of N2 might reflect enhanced conflict resolution during stimulus processing. The CRN, however, might reflect postresponse implementation of cognitive control, which is reduced when conflict is already adequately resolved during stimulus processing. Furthermore, N2 and CRN in incompatible trials were inversely related on the between- and within-subject level, implying that the two modes of implementing cognitive control are applied complementarily.
Epigenetics · 36 Zitationen · DOI
Obsessive-compulsive disorder (OCD) has recently been linked to increased methylation levels in the oxytocin receptor (<i>OXTR</i>) gene, and <i>OXTR</i> hypermethylation has predicted a worse treatment response to cognitive-behavioural therapy (CBT). Furthermore, OCD is associated with childhood trauma and stressful life events, which have both been shown to affect <i>OXTR</i> methylation. Here, we aimed to replicate findings of increased <i>OXTR</i> methylation as a predictor of disease and worse treatment response in an independent sample that received treatment within the public health care system. In addition, we aimed to extend previous findings by examining associations between <i>OXTR</i> hypermethylation, environmental stressors, OCD diagnosis, and treatment response. Methylation levels at two CpGs within <i>OXTR</i> exon III were compared between <i>n</i> = 181 OCD patients and <i>n</i> = 199 healthy controls using linear regression analysis. In a subsample of OCD patients (<i>n</i> = 98) with documented treatment data, we examined associations between methylation and treatment response to CBT. Childhood adversity and stressful life events were assessed using Childhood Trauma Questionnaire and Life Experience Survey, respectively. OCD patients exhibited significant hypermethylation at CpG site cg04523291 compared to controls, and increased methylation was associated with impaired treatment response. Moreover, hypermethylation at cg04523291 was associated with stressful life events in OCD patients, and with childhood adversity in controls. Yet, there were no significant mediation effects. In conclusion, we replicated the association between <i>OXTR</i> hypermethylation and OCD in the largest sample, so far. Furthermore, our findings support the role of <i>OXTR</i> methylation as a promising biomarker for treatment response in OCD.
Acta Psychiatrica Scandinavica · 24 Zitationen · DOI
Our findings support the polygenic nature of OCD and further validate harm avoidance as a candidate endophenotype and diathesis of OCD.
Scientific Reports · 22 Zitationen · DOI
Alterations in frontal and parietal neural activations during working memory task performance have been suggested as a candidate endophenotype of obsessive-compulsive disorder (OCD) in studies involving first-degree relatives. However, the direct link between genetic risk for OCD and neuro-functional alterations during working memory performance has not been investigated to date. Thus, the aim of the current functional magnetic resonance imaging (fMRI) study was to test the direct association between polygenic risk for OCD and neural activity during the performance of a numeric n-back task with four working memory load conditions in 128 participants, including patients with OCD, unaffected first-degree relatives of OCD patients, and healthy controls. Behavioral results show a significant performance deficit at high working memory load in both patients with OCD and first-degree relatives (p < 0.05). A whole-brain analysis of the fMRI data indicated decreased neural activity in bilateral inferior parietal lobule and dorsolateral prefrontal cortex in both patients and relatives. Most importantly, OCD polygenic risk scores predicted neural activity in orbitofrontal cortex. Results indicate that genetic risk for OCD can partly explain alterations in brain response during working memory performance, supporting the notion of a neuro-functional endophenotype for OCD.
Journal of Anxiety Disorders · 20 Zitationen · DOI
Frontiers in Psychiatry · 20 Zitationen · DOI
Increasing evidence indicates that patients with obsessive-compulsive disorder (OCD) exhibit alterations in fronto-striatal circuitry. Performance deficits in the antisaccade task would support this model, but results from previous small-scale studies have been inconclusive as either increased error rates, prolonged antisaccade latencies, both or neither have been reported in OCD patients. In order to address this issue, we investigated antisaccade performance in a large sample of OCD patients (<i>n</i> = 169) and matched control subjects (<i>n</i> = 183). As impaired antisaccade performance constitutes a potential endophenotype of OCD, unaffected first-degree relatives of OCD patients (<i>n</i> = 100) were assessed, as well. Furthermore, we conducted a quantitative meta-analysis to integrate our data with previous findings. In the empirical study, OCD patients exhibited significantly increased antisaccade latencies, intra-subject variability (ISV) of antisaccade latencies, and antisaccade error rates. The latter effect was driven by errors with express latency (80-130 ms), as patients did not differ significantly from controls with regards to regular errors (>130 ms). Notably, unaffected relatives of OCD patients showed elevated antisaccade express error rates and increased ISV of antisaccade latencies, as well. Antisaccade performance was not associated with state anxiety within groups. Among relatives, however, we observed a significant correlation between antisaccade error rate and harm avoidance. Medication status of OCD patients, symptom severity, depressive comorbidity, comorbid anxiety disorders and OCD symptom dimensions did not significantly affect antisaccade performance. Meta-analysis of 10 previous and the present empirical study yielded a medium-sized effect (<i>SMD</i> = 0.48, <i>p</i> < 0.001) for higher error rates in OCD patients, while the effect for latencies did not reach significance owing to strong heterogeneity (<i>SMD</i> = 0.51, <i>p</i> = 0.069). Our results support the assumption of impaired antisaccade performance in OCD, although effects sizes were only moderately large. Furthermore, we provide the first evidence that increased antisaccade express error rates and ISV of antisaccade latencies may constitute endophenotypes of OCD. Findings regarding these more detailed antisaccade parameters point to potentially underlying mechanisms, such as early pre-stimulus inhibition of the superior colliculus.
Journal of Abnormal Psychology · 15 Zitationen · DOI
Frontal electroencephalographic alpha asymmetry as an indicator of trait approach and trait inhibition systems has previously been studied in individuals with obsessive-compulsive disorder (OCD) with mixed results. We explored frontal alpha asymmetry as a possible risk factor in OCD by investigating a large sample of OCD patients (n = 113), healthy control participants (n = 113), and unaffected 1st-degree relatives of OCD patients (n = 37). Additionally, the relationship between OCD symptom dimensions and frontal alpha asymmetry was explored. OCD patients and healthy control participants did not differ in alpha asymmetry scores. Hence, the current results do not support the notion that OCD as a diagnostic entity is associated with a shift in frontal cortical activity. Furthermore, alpha asymmetry scores were not statistically related to specific OCD symptom dimensions. Reasons for inconsistent results in OCD are discussed and should be explored in future studies. Compared to OCD patients and healthy control participants, unaffected 1st-degree relatives of OCD patients showed increased left frontal activity. Such asymmetry has previously been found to be associated with positive affect and adaptive emotion regulation under stress. Because stressful life events play an important role in the onset and exacerbation of OCD, increased left frontal activity might serve as a resilience factor in unaffected 1st-degree relatives. Future studies should follow up on these results with longitudinal risk studies and pre- and posttherapy assessments to further explore causality of this putative factor. (PsycINFO Database Record
Psychophysiology · 14 Zitationen · DOI
Previous research has demonstrated that task-irrelevant emotional distractors interfere with task performance especially under low phasic executive control (i.e., in nonconflict trials). In the present study, we measured medio-frontal ERPs (N2 and correct-related negativity, CRN) to elucidate which aspects of task performance are affected by emotional interference in a flanker task. To create emotional interference, negative and neutral pictures were presented during the flanker stimuli. N2 and CRN were reduced after negative pictures, indicating that conflict processing and performance monitoring are both affected by emotional interference. On the behavioral level, prolonged response times after negative pictures were observed under low phasic executive control (i.e., in compatible trials). Additionally, we explored whether emotional interference is modulated not only by phasic changes in executive control (i.e., conflict vs. nonconflict trials) but also by tonic changes in executive control (i.e., low vs. high overall conflict frequency). To this end, the flanker task consisted of two blocks with 25% versus 75% incompatible trials. Prolonged response times after negative pictures in compatible trials were observed only under low tonic executive control but not under high executive control.
European Archives of Psychiatry and Clinical Neuroscience · 13 Zitationen · DOI
Biological Psychiatry Global Open Science · 8 Zitationen · DOI
Increased supplementary motor area and default mode network activity in patients with OCD replicates previous studies and might indicate excessive error signals and increased self-referential error processing. Increased activity of the inferior frontal gyrus in relatives may reflect increased inhibition. Impaired response inhibition in OCD has been demonstrated in several studies and might contribute to impairments in suppressing compulsive actions. Thus, increased inferior frontal gyrus activity in the unaffected relatives of patients with OCD may have contributed to protection from symptom development.
NeuroImage Clinical · 6 Zitationen · DOI
The present results illustrate that the inclusion of error-related SMN activity can significantly increase treatment response prediction quality in OCD. Stronger error-related activity of the SMN may reflect the ability to activate symptom-relevant processing networks and may thus facilitate response to exposure-based CBT interventions.
PLoS ONE · 6 Zitationen · DOI
Intact executive functions are characterized by flexible adaptation to task requirements, while these effects are reduced in internalizing disorders. Furthermore, as executive functions play an important role in emotion regulation, deficits in executive functions may contribute to symptom generation in psychological disorders through increased emotional interference. Thus, the present study investigated transfer effects of a three-week executive control training on adaptation to task difficulty and emotional interference in healthy participants (n = 24) to further explore the training's suitability for clinical application. To assess the adaptation to task difficulty, the proportion congruency effect on behavioral data (response times, error rates) and ERP measures (N2, CRN) was assessed in a flanker task with varying frequency of incompatible trials (25%, 75%). To quantify emotional interference, flanker stimuli were superimposed on neutral or negative pictures. Replicating previous results, the training increased interference control as indexed by decreased response times and errors rates, increased N2 amplitude and decreased CRN amplitude in incompatible trials after training. Proportion congruency effects were weaker than expected and not affected by the training intervention. The training lead to a shift in the time-point of emotional interference: before training negative pictures lead to a reduction in CRN amplitude, while after training this reduction was observed for the N2. This pattern illustrates that the training leads to a change in task processing mode from predominant response-related cognitive control to predominant stimulus-related cognitive control (N2), indicating a proactive processing mode.
Psychophysiology · 5 Zitationen · DOI
Cognitive control is flexibly adapted to task requirements in healthy individuals. Medio-frontal negativities in the event-related potential of the electroencephalogram can serve as indicators of cognitive control. With increasing conflict frequency, stimulus-locked control, as indexed by the N2, is increased and response-locked control, as indexed by the correct-related negativity, is reduced. On the behavioral level, this shift is associated with improved conflict resolution as evident in reduced response times and error rates in incompatible trials and a reduced response time congruency effect. Cognitive control adaptation might be implemented through experience-based task sets specifying advantageous processing strategies. Here, we investigated whether the cognitive control task set will be sustained when coupled with a contextual cue, even when the initial task requirements are no longer present. A flanker task with two conflict frequency conditions (25% incompatible and 75% incompatible trials) was presented. In the training phase, the conflict frequency conditions were paired with a distinct context cue (i.e., background color). In the test phase, the previously associated cues were again presented, but conflict frequency was identical in both conditions (50% incompatible trials). Although typical cognitive control adaptation was observed in the training phase on the behavioral and event-related potentials level, this pattern was not sustained in the test phase. Thus, the present study provides further evidence that cognitive control is flexibly adapted to task requirements even in the presence of misleading cues.
Biological Psychology · 4 Zitationen · DOI
Altered heart rate (HR) and heart rate variability (HRV) are common observations in psychiatric disorders. Yet, few studies have examined these cardiac measures in obsessive-compulsive disorder (OCD). The current study aimed to investigate HR and HRV, indexed by the root mean square of successive differences (RMSSD) and further time domain indices, as putative biological characteristics of OCD. Electrocardiogram was recorded during a five-minute resting state. Group differences between patients with OCD (n = 96), healthy participants (n = 112), and unaffected first-degree relatives of patients with OCD (n = 47) were analyzed. As potential moderators of group differences, we examined the influence of age and medication, respectively. As results indicated, patients with OCD showed higher HR and lower HRV compared to healthy participants. These group differences were not moderated by age. Importantly, subgroup analyses showed that only medicated patients displayed lower HRV compared to healthy individuals, while HR alterations were evident in unmedicated patients. Regarding unaffected first-degree relatives, group differences in HRV remained at trend level. Further, an age-moderated group differentiation showed that higher HRV distinguished relatives from healthy individuals in young adulthood, whereas at higher age lower HRV was indicative of relatives. Both the role of familial risk and medication in HRV alterations need further elucidation. Pending future studies, alterations in HR and potentially HRV might serve as useful indices to characterize the pathophysiology of OCD.
European Neuropsychopharmacology · 4 Zitationen · DOI
International Journal of Psychophysiology · 3 Zitationen · DOI
Psychophysiology · 3 Zitationen · DOI
Recent evidence indicates that patients with obsessive-compulsive disorder (OCD) as well as their unaffected first-degree relatives show deficits in the volitional control of saccades, suggesting that volitional saccade performance may constitute an endophenotype of OCD. Here, we aimed to replicate and extend these findings in a large, independent sample. One hundred and fifteen patients with OCD, 103 healthy comparison subjects without a family history of OCD, and 31 unaffected first-degree relatives of OCD patients were examined using structured clinical interviews and performed a volitional saccade task as well as a prosaccade task. In contrast to previous reports, neither patients nor relatives showed impairments in the performance of volitional saccades compared to healthy controls. Notably, medicated patients did not differ from nonmedicated patients, and there was no effect of depressive comorbidity. Additional analyses investigating correlations between saccade performance and OCD symptom dimensions yielded no significant associations. In conclusion, the present results do not support the notion that volitional saccade execution constitutes an endophenotype of OCD. Possible explanations for inconsistencies with previous studies are discussed.
European Neuropsychopharmacology · 2 Zitationen · DOI
BJPsych Open · 2 Zitationen · DOI
Summary Studies have shown that people with obsessive–compulsive disorder (OCD) have impairments in spatial working memory (SWM) performance. However, it remains unclear whether this deficit represents a cognitive endophenotype preceding symptoms or a correlate of OCD. We investigated SWM in 69 people with OCD, 77 unaffected first-degree relatives of people with OCD and 106 healthy control participants. Taking age effects into account, SWM performance was best in healthy controls, intermediate in relatives and worst in OCD participants. However, since performance did not differ significantly between healthy controls and relatives, our study does not fully support SWM performance as a core cognitive endophenotype of OCD.
Kooperationen1
Bestätigte Forscher↔Partner-Paare aus HU-FIS — Gold-Standard-Positive für das Matching.
Neurokognitive Adaptivität und deren Beeinflussung durch kognitives Training bei Patienten mit Zwangsstörung
university
Stammdaten
Identität, Organisation und Kontakt aus HU-FIS.
- Name
- Dr. rer. nat. Rosa Grützmann
- Titel
- Dr. rer. nat.
- Fakultät
- Lebenswissenschaftliche Fakultät
- Institut
- Institut für Psychologie
- Arbeitsgruppe
- Klinische Psychologie
- Telefon
- +49 30 2093-4918
- HU-FIS-Profil
- Quelle ↗
- Zuletzt gescrapt
- 26.4.2026, 01:05:27