Dr. rer. nat. Rosa Grützmann

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Zusammenfassung

Dr. Grützmann erforscht die neuronalen Grundlagen von Zwangsstörungen, insbesondere wie das Gehirn Fehler überwacht und verarbeitet. Sie nutzt bildgebende Verfahren und elektrophysiologische Messungen, um zu verstehen, welche kognitiven und genetischen Faktoren zur Entstehung von Zwangsstörungen beitragen — mit dem Ziel, biologische Marker für Diagnose und Therapieerfolg zu identifizieren.

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Name

Dr. rer. nat. Rosa Grützmann

Titel

Dr. rer. nat.

Fakultät

Lebenswissenschaftliche Fakultät

Institut

Institut für Psychologie

Arbeitsgruppe

Klinische Psychologie

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Zuletzt gescrapt

11.6.2026, 01:06:17

• Neurokognitive Adaptivität und deren Beeinflussung durch kognitives Training bei Patienten mit Zwangsstörung

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  Förderer: DFG Sachbeihilfe Zeitraum: 04/2018 - 11/2022 Projektleitung: Dr. rer. nat. Rosa Grützmann

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• Error-related brain activity as a transdiagnostic endophenotype for obsessive-compulsive disorder, anxiety and substance use disorder

  2019

  Psychological Medicine · 131 Zitationen · DOI

  BACKGROUND: Increased neural error-signals have been observed in obsessive-compulsive disorder (OCD), anxiety disorders, and inconsistently in depression. Reduced neural error-signals have been observed in substance use disorders (SUD). Thus, alterations in error-monitoring are proposed as a transdiagnostic endophenotype. To strengthen this notion, data from unaffected individuals with a family history for the respective disorders are needed. METHODS: The error-related negativity (ERN) as a neural indicator of error-monitoring was measured during a flanker task from 117 OCD patients, 50 unaffected first-degree relatives of OCD patients, and 130 healthy comparison participants. Family history information indicated, that 76 healthy controls were free of a family history for psychopathology, whereas the remaining had first-degree relatives with depression (n = 28), anxiety (n = 27), and/or SUD (n = 27). RESULTS: Increased ERN amplitudes were found in OCD patients and unaffected first-degree relatives of OCD patients. In addition, unaffected first-degree relatives of individuals with anxiety disorders were also characterized by increased ERN amplitudes, whereas relatives of individuals with SUD showed reduced amplitudes. CONCLUSIONS: Alterations in neural error-signals in unaffected first-degree relatives with a family history of OCD, anxiety, or SUD support the utility of the ERN as a transdiagnostic endophenotype. Reduced neural error-signals may indicate vulnerability for under-controlled behavior and risk for substance use, whereas a harm- or error-avoidant response style and vulnerability for OCD and anxiety appears to be associated with increased ERN. This adds to findings suggesting a common neurobiological substrate across psychiatric disorders involving the anterior cingulate cortex and deficits in cognitive control.

• Presupplementary Motor Area Contributes to Altered Error Monitoring in Obsessive-Compulsive Disorder

  2014

  Biological Psychiatry · 82 Zitationen · DOI

• Response accuracy rating modulates ERN and Pe amplitudes

  2013

  Biological Psychology · 56 Zitationen · DOI

• Freie Universität Berlin

  Neurokognitive Adaptivität und deren Beeinflussung durch kognitives Training bei Patienten mit Zwangsstörung

  university