Prof. Dr. habil. rer. nat. Gudrun A. Brockmann

Profil

Zusammenfassung

Prof. Brockmann erforscht die genetischen und molekularen Grundlagen von Adipositas, Stoffwechselstörungen und Reproduktionsmerkmalen bei Nutztieren und Modellorganismen. Sie entwickelt genomische Werkzeuge wie SNP-Chips für Zuchtprogramme und nutzt Kopplungsanalysen sowie Assoziationsstudien, um Gene zu identifizieren, die Körperfettansatz, Insulinsensitivität und funktionale Merkmale beeinflussen. Ihre Expertise ermöglicht es Züchtern und der Agrarwirtschaft, genetische Marker zur Verbesserung von Tiergesundheit, Leistung und nachhaltiger Produktion einzusetzen.

Skills

Name

Prof. Dr. habil. rer. nat. Gudrun A. Brockmann

Titel

Prof. Dr. habil. rer. nat.

Fakultät

Lebenswissenschaftliche Fakultät

Institut

Albrecht Daniel Thaer-Institut für Agrar- und Gartenbauwissenschaften

Arbeitsgruppe

Tierzüchtung und molekulare Genetik

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HU-FIS-Profil

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27.6.2026, 01:04:08

• Aufklärung epigenetischer Modifikation als Einflussfaktor auf den Fettansatz und die Körperfettverteilung in der Berliner Fettmaus als Modelltier

  Quelle ↗

  Förderer: DFG Sachbeihilfe Zeitraum: 10/2012 - 11/2018 Projektleitung: Prof. Dr. habil. rer. nat. Gudrun A. Brockmann

• Aufklärung genetischer Ursachen für differenzierte Muskelmerkmale, insbesondere Wasserbindevermögen, unter Nutzung selektierter Mauslinien

  Quelle ↗

  Förderer: DFG Sachbeihilfe Zeitraum: 09/2007 - 02/2014 Projektleitung: Prof. Dr. habil. rer. nat. Gudrun A. Brockmann

• Aufklärung molekularer Mechanismen, die am jObes1 Lokus den juvenilen Fettansatz in der Berliner Fettmaus verursachen

  Quelle ↗

  Förderer: DFG Sachbeihilfe Zeitraum: 12/2018 - 09/2023 Projektleitung: Prof. Dr. habil. rer. nat. Gudrun A. Brockmann

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• Coat Color Variation at the Beginning of Horse Domestication

  2009

  Science · 314 Zitationen · DOI

  The transformation of wild animals into domestic ones available for human nutrition was a key prerequisite for modern human societies. However, no other domestic species has had such a substantial impact on the warfare, transportation, and communication capabilities of human societies as the horse. Here, we show that the analysis of ancient DNA targeting nuclear genes responsible for coat coloration allows us to shed light on the timing and place of horse domestication. We conclude that it is unlikely that horse domestication substantially predates the occurrence of coat color variation, which was found to begin around the third millennium before the common era.

• A New Standard Genetic Map for the Laboratory Mouse

  2009

  Genetics · 244 Zitationen · DOI

  Genetic maps provide a means to estimate the probability of the co-inheritance of linked loci as they are transmitted across generations in both experimental and natural populations. However, in the age of whole-genome sequences, physical distances measured in base pairs of DNA provide the standard coordinates for navigating the myriad features of genomes. Although genetic and physical maps are colinear, there are well-characterized and sometimes dramatic heterogeneities in the average frequency of meiotic recombination events that occur along the physical extent of chromosomes. There also are documented differences in the recombination landscape between the two sexes. We have revisited high-resolution genetic map data from a large heterogeneous mouse population and have constructed a revised genetic map of the mouse genome, incorporating 10,195 single nucleotide polymorphisms using a set of 47 families comprising 3546 meioses. The revised map provides a different picture of recombination in the mouse from that reported previously. We have further integrated the genetic and physical maps of the genome and incorporated SSLP markers from other genetic maps into this new framework. We demonstrate that utilization of the revised genetic map improves QTL mapping, partially due to the resolution of previously undetected errors in marker ordering along the chromosome.

• Quantitative Trait Loci Mapping of Functional Traits in the German Holstein Cattle Population

  2003

  Journal of Dairy Science · 165 Zitationen · DOI

  A whole-genome scan to detect quantitative trait loci (QTL) for functional traits was performed in the German Holstein cattle population. For this purpose, 263 genetic markers across all autosomes and the pseudoautosomal region of the sex chromosomes were genotyped in 16 granddaughter-design families with 872 sons. The traits investigated were deregressed breedingvalues for maternal and direct effects on dystocia (DYSm, DYSd) and stillbirth (STIm, STId) as well as maternal and paternal effects on nonreturn rates of 90 d (NR90m, NR90p). Furthermore, deregressed breeding values for functional herd life (FHL) and daughter yield deviation for somatic cell count (SCC) were investigated. Weighted multimarker regression analyses across families and permutation tests were applied for the detection of QTL and the calculation of statistical significance. A ten percent genomewise significant QTL was localized for DYSm on chromosome 8 and for SCC on chromosome 18. A further 24 putative QTL exceeding the 5% chromosomewise threshold were detected. On chromosomes 7, 8, 10, 18, and X/Yps, coincidence of QTL for several traits was observed. Our results suggest that loci with influence on udder health may also contribute to genetic variance of longevity. Prior to implementation of these QTL in marker assisted selection programs for functional traits, information about direct and correlated effects of these QTL as well as fine mapping of their chromosomal positions is required.

• Evonik Nutrition & Care GmbH

  UfIB: Etablierung und Anwendung von In-Vitro-Methoden zur Untersuchung immunomodulatorischer Wirkungen von zootechnischen Futterzusatzstoffen beim Huhn

  company

• H. Wilhelm Schaumann Stiftung

  Wechselwirkung zwischen Veranlagung, Erregerspektrum und Erkrankung an Mastitis

  foundation

• Institut für Fortpflanzung landwirtschaftlicher Nutztiere Schönow e.V.

  Bereitstellung tierzüchterischer Marker für die Verbesserung der Züchtung innerhalb der gefährdeten Rasse DSN zur besonders tiergerechten und nachhaltigen Produktion tierischer Erzeugnisse

  other