Prof. Dr. Lydia Fehm
Profil
Forschungsthemen4
FOR 5187/1: Einzelfallprädiktion des Behandlungsergebnisses einer kognitiven Verhaltenstherapie im ambulanten Sektor: eine prospektiv-longitudinale Beobachtungsstudie (TP 1)
Quelle ↗Förderer: DFG Forschungsgruppe Zeitraum: 07/2022 - 06/2027 Projektleitung: Prof. Dr. Ulrike Lüken
FOR 5187/1: Einzelfallprädiktion des Behandlungsergebnisses einer kognitiven Verhaltenstherapie im ambulanten Sektor: eine prospektiv-longitudinale Beobachtungsstudie (TP 1)
Quelle ↗Förderer: DFG Forschungsgruppe Zeitraum: 07/2022 - 06/2026 Projektleitung: Prof. Dr. Ulrike Lüken, Prof. Dr. Lydia Fehm
FOR 5187/1: Einzelfallprädiktion des Behandlungsergebnisses einer kognitiven Verhaltenstherapie im ambulanten Sektor: Eine prospektiv-longitudinale Beobachtungsstudie (TP 1)
Quelle ↗Förderer: DFG Forschungsgruppe Zeitraum: 07/2022 - 06/2026 Projektleitung: Prof. Dr. rer. nat. Norbert Kathmann, Prof. Dr. Ulrike Lüken, Prof. Dr. Lydia Fehm
FOR 5187/1: Personalisierte Psychotherapie für Patient*innen mit fehlendem Behandlungserfolg: Mechanismen, prädiktive Marker und klinische Anwendung (Koordinationsfonds)
Quelle ↗Förderer: DFG Forschungsgruppe Zeitraum: 08/2022 - 08/2027 Projektleitung: Prof. Dr. Ulrike Lüken
Mögliche Industrie-Partner10
Stand: 26.4.2026, 19:48:44 (Top-K=20, Min-Cosine=0.4)
- 87 Treffer75.9%
- FOR 5187: Personalisierte Psychotherapie für Patient*innen mit fehlendem Behandlungserfolg: Mechanismen, prädiktive Marker und klinische AnwendungT75.9%
- FOR 5187: Personalisierte Psychotherapie für Patient*innen mit fehlendem Behandlungserfolg: Mechanismen, prädiktive Marker und klinische Anwendung
- 76 Treffer58.9%
- FOR 5177/2: Korrelation der Leistungsfähigkeit der Lendenwirbelsäule mit klinischen Outcomes nach einer gezielten Behandlung bei Patienten mit unteren Rückenschmerzen (TP 04)T58.9%
- FOR 5177/2: Korrelation der Leistungsfähigkeit der Lendenwirbelsäule mit klinischen Outcomes nach einer gezielten Behandlung bei Patienten mit unteren Rückenschmerzen (TP 04)
- 10 Treffer56.7%
- Zuwendung im Rahmen des Programms „exist – Existenzgründungen aus der Wissenschaft“ aus dem Bundeshaushalt, Einzelplan 09, Kapitel 02, Titel 68607, Haushaltsjahr 2026, sowie aus Mitteln des Europäischen Strukturfonds (hier Euro-päischer Sozialfonds Plus – ESF Plus) Förderperiode 2021-2027 – Kofinanzierung für das Vorhaben: „exist Women“T56.7%
- Zuwendung im Rahmen des Programms „exist – Existenzgründungen aus der Wissenschaft“ aus dem Bundeshaushalt, Einzelplan 09, Kapitel 02, Titel 68607, Haushaltsjahr 2026, sowie aus Mitteln des Europäischen Strukturfonds (hier Euro-päischer Sozialfonds Plus – ESF Plus) Förderperiode 2021-2027 – Kofinanzierung für das Vorhaben: „exist Women“
- 27 Treffer53.6%
- EXGAVINE: Bewegungsspiele in der Virtuellen Realität als Therapieform neurologischer ErkrankungenP53.6%
- EXGAVINE: Bewegungsspiele in der Virtuellen Realität als Therapieform neurologischer Erkrankungen
- 26 Treffer53.6%
- EXGAVINE: Bewegungsspiele in der Virtuellen Realität als Therapieform neurologischer ErkrankungenP53.6%
- EXGAVINE: Bewegungsspiele in der Virtuellen Realität als Therapieform neurologischer Erkrankungen
- 16 Treffer53.3%
- Workshop Reliable Methods and Mathematical ModelingP53.3%
- Workshop Reliable Methods and Mathematical Modeling
- 16 Treffer53.0%
- Pädagogik im Berliner JugendvollzugP53.0%
- Pädagogik im Berliner Jugendvollzug
- 47 Treffer52.8%
- Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other StrategiesP52.8%
- Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other Strategies
- 49 Treffer52.8%
- Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other StrategiesP52.8%
- Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other Strategies
- 49 Treffer52.8%
- Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other StrategiesP52.8%
- Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other Strategies
Publikationen25
Top 25 nach Zitationen — Quelle: OpenAlex (BAAI/bge-m3 embedded für Matching).
Acta Psychiatrica Scandinavica · 384 Zitationen · DOI
Prospective longitudinal studies in representative samples drawn from the general population provide information that allows the overall direct and indirect costs of the disorder (treatment costs, disability, social welfare) to be determined, and enables an improvement in long-term care strategies as well as preventive efforts to be established.
European Neuropsychopharmacology · 372 Zitationen · DOI
Social Psychiatry and Psychiatric Epidemiology · 338 Zitationen · DOI
The British Journal of Psychiatry · 227 Zitationen · DOI
The risk of developing major depressive disorder after traumatisation in childhood is approximately equal to the risk of developing PTSD. After age 13 years, the risk of PTSD is greater than the risk of major depression after traumatisation.
Journal of Consulting and Clinical Psychology · 202 Zitationen · DOI
Therapist-guided exposure is more effective for agoraphobic avoidance, overall functioning, and panic attacks in the follow-up period than is CBT without therapist-guided exposure. Therapist-guided exposure promotes additional therapeutic improvement--possibly mediated by increased physical engagement in feared situations--beyond the effects of a CBT treatment in which exposure is simply instructed.
Journal of Anxiety Disorders · 196 Zitationen · DOI
Molecular Psychiatry · 171 Zitationen · DOI
Acta Psychiatrica Scandinavica · 169 Zitationen · DOI
A persistent course with a considerable degree of fluctuations in symptom severity is characteristic for SAD. Both consistently meeting full threshold diagnostic criteria and complete remissions are rare. Vulnerability and clinical severity indicators predict poor prognosis and might be helpful markers for intervention needs.
Behavioural and Cognitive Psychotherapy · 150 Zitationen · DOI
Homework assignments are an essential part of cognitive-behavioural therapy, and are included in the majority of therapy manuals and frequently used in therapeutic practice. Despite this, little is known about problems with homework completion or possible influences on homework compliance. The aim of the present practitioner survey was to provide data on problems related to homework use and compliance. Furthermore, the relationships between different variables and homework compliance were examined. Data were collected by asking 77 cognitive-behavioural therapists to recall two individual patients. Therapists described homework tasks assigned to these patients and procedures of assignment as well as problems that arose during assignment and completion. The results suggested that problems during the assignation of a task as well as during completion regularly occur. Homework compliance was positively associated both with patients' motivation for therapy, outcome at a later stage of therapy, and the provision of a written note or homework sheets on the task. Regression analyses pointed to patient variables as most crucial for homework compliance. Implications for effective homework use in clinical practice are discussed.
Psychiatric Clinics of North America · 150 Zitationen · DOI
Molecular Psychiatry · 146 Zitationen · DOI
Depression and Anxiety · 106 Zitationen · DOI
Parental psychopathology and rearing were associated with offspring SP, independently as well as in their interaction. Further delineation of these associations is warranted as malleable components of these risk factors may provide potential targets for prevention programs. In addition, parent-to-offspring transmission of other internalizing disorders should be considered to examine the degree of diagnostic specificity.
Molecular Psychiatry · 105 Zitationen · DOI
Journal of Psychiatric Research · 105 Zitationen · DOI
Journal of Behavior Therapy and Experimental Psychiatry · 104 Zitationen · DOI
European Archives of Psychiatry and Clinical Neuroscience · 95 Zitationen · DOI
Anxiety Stress & Coping · 92 Zitationen · DOI
To understand mental disorders, analogue paradigms provide an indispensable contribution. In posttraumatic stress disorder (PTSD), the stressful film paradigm is a frequently used analogue approach: Films depicting traumatic events are shown to non-clinical participants in order to elicit stress responses analogue to responses to traumatic events in real life. Previous studies used a large variety of films, which is problematic with regard to the comparability of results. The main goal of this study was to identify a film clip that (a) consistently provokes stress reactions and (b) provokes reactions that are as similar as possible to traumatic stress. We randomly exposed 105 male and female participants to one of four stressful films, differing, e.g., in content and origin. Intrusive memories of the film, reported immediately after the film and during a diary phase of three days, as well as distress, heart rate, and several mood states were measured. A film clip depicting rape elicited the most consistent reactions that were characterized by a higher heart rate, more distress and more intrusive memories, compared to the other three clips. Intrusive memories across all films were especially related to an increase in heart rate and disgust in response to the film.
Journal of Anxiety Disorders · 85 Zitationen · DOI
Clinical Psychological Science · 84 Zitationen · DOI
Individual responses to behavioral treatment of anxiety disorders vary considerably, which requires a better understanding of underlying processes. In this study, we examined the violation and change of threat beliefs during exposure. From 8,484 standardized exposure records of 605 patients with different anxiety disorders, learning indicators were derived: expectancy violation as mismatch between threat expectancy before exposure and threat occurrence, expectancy change as difference between original and adjusted expectancy after exposure, and prediction-error learning rate as extent to which expectancy violation transferred into change. Throughout sessions, high threat expectancy but low occurrence and adjusted expectancy indicated successful violation and change of threat beliefs by exposure. Expectancy violation, change, and learning rate substantially varied between patients. Not expectancy violation itself, but higher learning rate and expectancy change predicted better treatment outcome. Successful exposure thus requires expectancy violation to induce actual expectancy change, supporting learning from prediction error as transdiagnostic mechanism underlying successful exposure therapy.
Biological Psychiatry · 81 Zitationen · DOI
Stress and Health · 78 Zitationen · DOI
Abstract Journalists frequently report on disasters. There is a growing evidence that they are subsequently at higher risk of post‐traumatic and depressive symptoms. We conducted an internet‐based study with 61 journalists who had covered the tsunami disaster in December 2004 from the affected region. The extent of trauma exposure, symptoms and social variables were assessed. About 8 months after the event, indications of post‐traumatic stress disorder were found in 6.6 per cent of the sample. Post‐traumatic and depressive symptoms were related to the extent of traumatic exposure and to several social variables, most importantly, a low degree of social acknowledgment by supervisor and colleagues. Copyright © 2007 John Wiley & Sons, Ltd.
Journal of Neural Transmission · 75 Zitationen · DOI
We examined parental psychopathology and family environment in subthreshold and DSM-IV threshold conditions of social anxiety disorder (SAD) in a representative cohort sample of 1,395 adolescents. Offspring and parental psychopathology was assessed using the DIA-X/M-CIDI; recalled parental rearing and family functioning via questionnaire. Diagnostic interviews in parents were supplemented by family history reports from offspring. The cumulative lifetime incidence was 23.07% for symptomatic SAD, and 18.38 and 7.41% for subthreshold and threshold SAD, respectively. The specific parent-to-offspring association for SAD occurred for threshold SAD only. For subthreshold and threshold SAD similar associations were found with other parental anxiety disorders, depression and substance use disorders. Parental rearing behaviour, but not family functioning, was associated with offspring threshold SAD, and although less strong and less consistent, also with subthreshold SAD. Results suggest a continued graded relationship between familial risk factors and offspring SAD. Parental psychopathology and negative parental styles may be used defining high-risk groups to assign individuals with already subthreshold conditions of SAD to early intervention programs.
Molecular Psychiatry · 64 Zitationen · DOI
Depression and Anxiety · 63 Zitationen · DOI
Both treatment variants focusing on the transdiagnostic exposure-based violation of threat beliefs were effective in reducing symptom severity and disability in severe anxiety disorders. Temporally intensified exposure resulted in faster treatment response with substantial public health benefits and lower drop-out during the exposure phase, without higher relapse. Clinicians can expect better or at least comparable outcomes when delivering exposure in a temporally intensified manner.
Molecular Psychiatry · 58 Zitationen · DOI
Common variation in the gene encoding the neuron-specific RNA splicing factor RNA Binding Fox-1 Homolog 1 (RBFOX1) has been identified as a risk factor for several psychiatric conditions, and rare genetic variants have been found causal for autism spectrum disorder (ASD). Here, we explored the genetic landscape of RBFOX1 more deeply, integrating evidence from existing and new human studies as well as studies in Rbfox1 knockout mice. Mining existing data from large-scale studies of human common genetic variants, we confirmed gene-based and genome-wide association of RBFOX1 with risk tolerance, major depressive disorder and schizophrenia. Data on six mental disorders revealed copy number losses and gains to be more frequent in ASD cases than in controls. Consistently, RBFOX1 expression appeared decreased in post-mortem frontal and temporal cortices of individuals with ASD and prefrontal cortex of individuals with schizophrenia. Brain-functional MRI studies demonstrated that carriers of a common RBFOX1 variant, rs6500744, displayed increased neural reactivity to emotional stimuli, reduced prefrontal processing during cognitive control, and enhanced fear expression after fear conditioning, going along with increased avoidance behaviour. Investigating Rbfox1 neuron-specific knockout mice allowed us to further specify the role of this gene in behaviour. The model was characterised by pronounced hyperactivity, stereotyped behaviour, impairments in fear acquisition and extinction, reduced social interest, and lack of aggression; it provides excellent construct and face validity as an animal model of ASD. In conclusion, convergent translational evidence shows that common variants in RBFOX1 are associated with a broad spectrum of psychiatric traits and disorders, while rare genetic variation seems to expose to early-onset neurodevelopmental psychiatric disorders with and without developmental delay like ASD, in particular. Studying the pleiotropic nature of RBFOX1 can profoundly enhance our understanding of mental disorder vulnerability.
Kooperationen3
Bestätigte Forscher↔Partner-Paare aus HU-FIS — Gold-Standard-Positive für das Matching.
FOR 5187/1: Personalisierte Psychotherapie für Patient*innen mit fehlendem Behandlungserfolg: Mechanismen, prädiktive Marker und klinische Anwendung (Koordinationsfonds)
university
FOR 5187/1: Personalisierte Psychotherapie für Patient*innen mit fehlendem Behandlungserfolg: Mechanismen, prädiktive Marker und klinische Anwendung (Koordinationsfonds)
university
FOR 5187/1: Personalisierte Psychotherapie für Patient*innen mit fehlendem Behandlungserfolg: Mechanismen, prädiktive Marker und klinische Anwendung (Koordinationsfonds)
other
Stammdaten
Identität, Organisation und Kontakt aus HU-FIS.
- Name
- Prof. Dr. Lydia Fehm
- Titel
- Prof. Dr.
- Fakultät
- Lebenswissenschaftliche Fakultät
- Institut
- Institut für Psychologie
- Telefon
- +49 30 2093-99111
- HU-FIS-Profil
- Quelle ↗
- Zuletzt gescrapt
- 26.4.2026, 01:04:31