Prof. Dr. Thomas Fydrich
Profil
Forschungsthemen5
Effective Care and Treatment of Anxiety Disorders II
Quelle ↗Förderer: Land Sachsen Zeitraum: 10/2017 - 12/2017 Projektleitung: Prof. Dr. Thomas Fydrich
Panik-Netz: Proof of concept and augmentation
Quelle ↗Förderer: Bundesministerium für Forschung, Technologie und Raumfahrt Zeitraum: 09/2011 - 03/2014 Projektleitung: Prof. Dr. Thomas Fydrich
Treating Psychosocial and Neural Consequences of Childhood Interpersonal Violence in Adults
Quelle ↗Förderer: Bundesministerium für Forschung, Technologie und Raumfahrt Zeitraum: 09/2013 - 10/2018 Projektleitung: Prof. Dr. Thomas Fydrich
Verbund Psychotherapie Panik - Therapiestudie P2: Zentrum Berlin-Adlershof: Improving CBT for panic by identifying the active ingredients and understanding the mechanisms of action - A multicenter study
Quelle ↗Förderer: Bundesministerium für Forschung, Technologie und Raumfahrt Zeitraum: 10/2006 - 09/2009 Projektleitung: Prof. Dr. Thomas Fydrich
ZPHU-Zentrum für Psychotherapie am Institut für Psychologie
Quelle ↗Zeitraum: 02/2007 - 10/2017 Projektleitung: Prof. Dr. Thomas Fydrich
Mögliche Industrie-Partner10
Stand: 26.4.2026, 19:48:44 (Top-K=20, Min-Cosine=0.4)
- 96 Treffer62.4%
- FOR 5187: Personalisierte Psychotherapie für Patient*innen mit fehlendem Behandlungserfolg: Mechanismen, prädiktive Marker und klinische AnwendungP62.4%
- FOR 5187: Personalisierte Psychotherapie für Patient*innen mit fehlendem Behandlungserfolg: Mechanismen, prädiktive Marker und klinische Anwendung
- 22 Treffer59.9%
- Der Sportverein als attraktive Lebenswelt im Aufwachsen von Kindern und Jugendlichen? - Teilprojekt im Rahmen von Move for HealthP59.9%
- Der Sportverein als attraktive Lebenswelt im Aufwachsen von Kindern und Jugendlichen? - Teilprojekt im Rahmen von Move for Health
- 58 Treffer59.2%
- EXGAVINE: Bewegungsspiele in der Virtuellen Realität als Therapieform neurologischer ErkrankungenP59.2%
- EXGAVINE: Bewegungsspiele in der Virtuellen Realität als Therapieform neurologischer Erkrankungen
- 56 Treffer59.2%
- EXGAVINE: Bewegungsspiele in der Virtuellen Realität als Therapieform neurologischer ErkrankungenP59.2%
- EXGAVINE: Bewegungsspiele in der Virtuellen Realität als Therapieform neurologischer Erkrankungen
- 85 Treffer58.9%
- FOR 5177/2: Korrelation der Leistungsfähigkeit der Lendenwirbelsäule mit klinischen Outcomes nach einer gezielten Behandlung bei Patienten mit unteren Rückenschmerzen (TP 04)P58.9%
- FOR 5177/2: Korrelation der Leistungsfähigkeit der Lendenwirbelsäule mit klinischen Outcomes nach einer gezielten Behandlung bei Patienten mit unteren Rückenschmerzen (TP 04)
- 37 Treffer58.7%
- Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other StrategiesP58.7%
- Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other Strategies
- 37 Treffer58.7%
- Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other StrategiesP58.7%
- Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other Strategies
- 37 Treffer58.7%
- Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other StrategiesP58.7%
- Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other Strategies
- 34 Treffer58.4%
- Modellierung und Transfer von Inhalts- und Qualitätskriterien für die Programmplanung in der finanziellen Bildung im ErwachsenenalterP58.4%
- Modellierung und Transfer von Inhalts- und Qualitätskriterien für die Programmplanung in der finanziellen Bildung im Erwachsenenalter
- Modellierung und Transfer von Inhalts- und Qualitätskriterien für die Programmplanung in der finanziellen Bildung im ErwachsenenalterP58.4%
- Modellierung und Transfer von Inhalts- und Qualitätskriterien für die Programmplanung in der finanziellen Bildung im Erwachsenenalter
Publikationen25
Top 25 nach Zitationen — Quelle: OpenAlex (BAAI/bge-m3 embedded für Matching).
Pain · 1233 Zitationen · DOI
Sixty-five studies that evaluated the efficacy of multidisciplinary treatments for chronic back pain were included in a meta-analysis. Within- and between-group effect sizes revealed that multidisciplinary treatments for chronic pain are superior to no treatment, waiting list, as well as single-discipline treatments such as medical treatment or physical therapy. Moreover, the effects appeared to be stable over time. The beneficial effects of multidisciplinary treatment were not limited to improvements in pain, mood and interference but also extended to behavioral variables such as return to work or use of the health care system. These results tend to support the efficacy of multidisciplinary pain treatment; however, these results must be interpreted cautiously as the quality of the study designs and study descriptions is marginal. Suggestions for improvement in research designs as well as appropriate reports of research completed are provided.
Journal of Anxiety Disorders · 774 Zitationen · DOI
Max Planck Institute for Plasma Physics · 199 Zitationen
Author: Fydrich, T. et al.; Genre: Book; Published in Print: 1997; Title: SKID II. Strukturiertes Klinisches Interview für DSM-IV, Achse II: Persönlichkeitsstörungen. Interviewheft. Eine deutschspeachige, erw. Bearb. d. amerikanischen Originalversion d. SKID-II von: M.B. First, R.L. Spitzer, M. Gibbon, J.B.W. Williams, L. Benjamin, (Version 3/96).
Psychoneuroendocrinology · 180 Zitationen · DOI
Behaviour Research and Therapy · 147 Zitationen · DOI
European Journal of Health Psychology · 107 Zitationen · DOI
Abstract. The primary aim of the current study was to examine the unique contribution of psychological need frustration and need satisfaction in the prediction of adults’ mental well-being and ill-being in a heterogeneous sample of adults ( N = 334; M age = 43.33, SD = 32.26; 53% females). Prior to this, validity evidence was provided for the German version of the Basic Psychological Need Satisfaction and Frustration Scale (BPNSFS) based on Self-Determination Theory (SDT). The results of the validation analyses found the German BPNSFS to be a valid and reliable measurement. Further, structural equation modeling (SEM) showed that both need satisfaction and frustration yielded unique and opposing associations with well-being. Specifically, the dimension of psychological need frustration predicted adults’ ill-being. Future research should examine whether frustration of psychological needs is involved in the onset and maintenance of psychopathology (e.g., major depressive disorder).
Behaviour Research and Therapy · 92 Zitationen · DOI
Biological Psychology · 87 Zitationen · DOI
Depression and Anxiety · 86 Zitationen · DOI
Our data suggest that depression impacts on maternal emotional availability during remission, which might represent a trait characteristic of depression. Mothers with depression in remission and additional severe childhood abuse were particularly affected. These findings may contribute to the understanding of children's vulnerability to develop a depressive disorder themselves.
Psychiatry Research · 82 Zitationen · DOI
Depression and Anxiety · 70 Zitationen · DOI
Participants with generalized social phobia (GSP) with (n=36) and without (n=19) avoidant personality disorder (AVPD) were compared via contrasts of group means and classification analysis on purported core features of AVPD. GSP-AVPD participants proved to be more severely impaired or distressed on some group contrasts. Cluster analysis identified two groups in the sample, with group membership significantly correlated to AVPD diagnosis. However, almost all significant findings were nullified when severity of social phobia was statistically controlled. Thus, at least where participants with social phobia are concerned, it seems most parsimonious to consider AVPD a severe form of GSP rather than a separate diagnostic category.
Journal of Psychiatry and Neuroscience · 65 Zitationen · DOI
During passive viewing of aversive images, individuals with SAD showed evidence of neural hyperreactivity that may be interpreted as increased bodily self-consciousness and heightened perspective-taking. During voluntary increase and decrease of negative emotional intensity, group differences disappeared, suggesting self-focused reappraisal as a successful emotion regulation strategy for individuals with SAD.
International Journal of Methods in Psychiatric Research · 55 Zitationen · DOI
Exposure-based psychological interventions currently represent the empirically best established first line form of cognitive-behavioural therapy for all types of anxiety disorders. Although shown to be highly effective in both randomized clinical and other studies, there are important deficits: (1) the core mechanisms of action are still under debate, (2) it is not known whether such treatments work equally well in all forms of anxiety disorders, including comorbid diagnoses like depression, (3) it is not known whether an intensified treatment with more frequent sessions in a shorter period of time provides better outcome than distributed sessions over longer time intervals. This paper reports the methods and design of a large-scale multicentre randomized clinical trial (RCT) involving up to 700 patients designed to answer these questions. Based on substantial advances in basic research we regard extinction as the putative core candidate model to explain the mechanism of action of exposure-based treatments. The RCT is flanked by four add-on projects that apply experimental neurophysiological and psychophysiological, (epi)genetic and ecological momentary assessment methods to examine extinction and its potential moderators. Beyond the focus on extinction we also involve stakeholders and routine psychotherapists in preparation for more effective dissemination into clinical practice.
Translational Psychiatry · 55 Zitationen · DOI
Serotonin receptor 1A gene (HTR1A) knockout mice show pronounced defensive behaviour and increased fear conditioning to ambiguous conditioned stimuli. Such behaviour is a hallmark of pathological human anxiety, as observed in panic disorder with agoraphobia (PD/AG). Thus, variations in HTR1A might contribute to neurophysiological differences within subgroups of PD/AG patients. Here, we tested this hypothesis by combining genetic with behavioural techniques and neuroimaging. In a clinical multicentre trial, patients with PD/AG received 12 sessions of manualized cognitive-behavioural therapy (CBT) and were genotyped for HTR1A rs6295. In four subsamples of this multicentre trial, exposure behaviour (n=185), defensive reactivity measured using a behavioural avoidance test (BAT; before CBT: n=245; after CBT: n=171) and functional magnetic resonance imaging (fMRI) data during fear conditioning were acquired before and after CBT (n=39). HTR1A risk genotype (GG) carriers more often escaped during the BAT before treatment. Exploratory fMRI results suggest increased activation of the amygdala in response to threat as well as safety cues before and after treatment in GG carriers. Furthermore, GG carriers demonstrated reduced effects of CBT on differential conditioning in regions including the bilateral insulae and the anterior cingulate cortex. Finally, risk genotype carriers demonstrated reduced self-initiated exposure behaviour to aversive situations. This study demonstrates the effect of HTR1A variation on defensive behaviour, amygdala activity, CBT-induced neural plasticity and normalization of defence behaviour in PD/AG. Our results, therefore, translate evidence from animal studies to humans and suggest a central role for HTR1A in differentiating subgroups of patients with anxiety disorders.
Behaviour Research and Therapy · 54 Zitationen · DOI
Journal of Behavior Therapy and Experimental Psychiatry · 52 Zitationen · DOI
International Journal of Psychiatry in Clinical Practice · 43 Zitationen · DOI
Patient satisfaction was high without differences between MDD and schizophrenia. Severity of disease and comorbidites in MDD and number of prescribed drugs in both groups were related with reduced patient satisfaction.
Schizophrenia Research · 41 Zitationen · DOI
Borderline Personality Disorder and Emotion Dysregulation · 41 Zitationen · DOI
Under routine mental health care conditions in Germany, outpatient DBT leads to positive results comparable to those reported in other effectiveness studies and in randomized controlled trials.
Clinical Trials · 39 Zitationen · DOI
The main aims of this research project are to study effects of endurance exercise and cognitive behavioral therapy on depressive symptoms and to investigate underlying physiological and neurobiological mechanisms of these effects. Results may provide important implications for the development of effective treatment strategies in major depressive disorder, specifically concerning the augmentation of cognitive behavioral therapy by endurance exercise.
Psychological Medicine · 37 Zitationen · DOI
This study revealed stronger region-specific activations in patients suffering from panic disorder with agoraphobia in anticipation of agoraphobia-specific stimuli. Patients seem to process these stimuli more intensively based on individual salience. Hyperactivation of the ventral striatum and insula when anticipating agoraphobia-specific situations might be a central neurofunctional correlate of agoraphobia. Knowledge about the neural correlates of anticipatory and perceptual processes regarding agoraphobic situations will help to optimize and evaluate treatments, such as exposure therapy, in patients with panic disorder and agoraphobia.
Journal of Consulting and Clinical Psychology · 36 Zitationen · DOI
Both DBT-PTSD and CPT emerged as promising treatment options for simultaneously addressing the full spectrum of core symptoms in patients diagnosed with BPD + PTSD. Differential efficacy was in favor of DBT-PTSD as participants randomized to the DBT-PTSD arm improved more with respect to both their BPD and PTSD symptoms. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
Journal of Psychiatric Research · 34 Zitationen · DOI
Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · 32 Zitationen · DOI
The SCID-II - which was primarily developed for use with adults - is suitable for use among adolescents. Anorexia nervosa (binge-purging type) and ADHD/CD are closely associated with the development of PD in adolescents.
Psychotherapy and Psychosomatics · 31 Zitationen · DOI
This publication is with permission of the rights owner freely accessible due to an alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
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Identität, Organisation und Kontakt aus HU-FIS.
- Name
- Prof. Dr. Thomas Fydrich
- Titel
- Prof. Dr.
- Fakultät
- Lebenswissenschaftliche Fakultät
- Institut
- Institut für Psychologie
- Telefon
- +49 30 2093-99107
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- 26.4.2026, 01:05:01