Prof. Dr. Thomas Fydrich

Profil

• Effective Care and Treatment of Anxiety Disorders II

  Quelle ↗

  Förderer: Land Sachsen Zeitraum: 10/2017 - 12/2017 Projektleitung: Prof. Dr. Thomas Fydrich

• Panik-Netz: Proof of concept and augmentation

  Quelle ↗

  Förderer: Bundesministerium für Forschung, Technologie und Raumfahrt Zeitraum: 09/2011 - 03/2014 Projektleitung: Prof. Dr. Thomas Fydrich

• Treating Psychosocial and Neural Consequences of Childhood Interpersonal Violence in Adults

  Quelle ↗

  Förderer: Bundesministerium für Forschung, Technologie und Raumfahrt Zeitraum: 09/2013 - 10/2018 Projektleitung: Prof. Dr. Thomas Fydrich

• Verbund Psychotherapie Panik - Therapiestudie P2: Zentrum Berlin-Adlershof: Improving CBT for panic by identifying the active ingredients and understanding the mechanisms of action - A multicenter study

  Quelle ↗

  Förderer: Bundesministerium für Forschung, Technologie und Raumfahrt Zeitraum: 10/2006 - 09/2009 Projektleitung: Prof. Dr. Thomas Fydrich

• ZPHU-Zentrum für Psychotherapie am Institut für Psychologie

  Quelle ↗

  Zeitraum: 02/2007 - 10/2017 Projektleitung: Prof. Dr. Thomas Fydrich

• HMU Research, Development und Innovation Erfurt gGmbH

  PT

  96 Treffer62.4%
  • FOR 5187: Personalisierte Psychotherapie für Patient*innen mit fehlendem Behandlungserfolg: Mechanismen, prädiktive Marker und klinische Anwendung
    P

    62.4%

• Deutsche Sportjugend

  P

  22 Treffer59.9%
  • Der Sportverein als attraktive Lebenswelt im Aufwachsen von Kindern und Jugendlichen? - Teilprojekt im Rahmen von Move for Health
    P

    59.9%

• RetroBrain R&D UG

  P

  58 Treffer59.2%
  • EXGAVINE: Bewegungsspiele in der Virtuellen Realität als Therapieform neurologischer Erkrankungen
    P

    59.2%

• Velamed GmbH Medizintechnik & Biomechanische Konzepte, Köln

  P

  56 Treffer59.2%
  • EXGAVINE: Bewegungsspiele in der Virtuellen Realität als Therapieform neurologischer Erkrankungen
    P

    59.2%

• MSB Research, Development and Innovation gGmbH

  PT

  85 Treffer58.9%
  • FOR 5177/2: Korrelation der Leistungsfähigkeit der Lendenwirbelsäule mit klinischen Outcomes nach einer gezielten Behandlung bei Patienten mit unteren Rückenschmerzen (TP 04)
    P

    58.9%

• Biopolis S.L.

  P

  37 Treffer58.7%
  • Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other Strategies
    P

    58.7%

• AnalytiCon Discovery GmbH

  P

  37 Treffer58.7%
  • Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other Strategies
    P

    58.7%

• Abiomics Europe KFT

  P

  37 Treffer58.7%
  • Validating C. Elegans Healthspan Model for Better Understanding Factors Causing Health and Disease, to Develop Evidence Based Prevention, Diagnostic, Therapeutic and Other Strategies
    P

    58.7%

• Lernende Region - Netzwerk Köln e.V.

  PT

  34 Treffer58.4%
  • Modellierung und Transfer von Inhalts- und Qualitätskriterien für die Programmplanung in der finanziellen Bildung im Erwachsenenalter
    P

    58.4%

• Katholische Erwachsenenbildung Deutschland - Bundesarbeitsgemeinschaft e. V.

  PT

  37 Treffer58.4%
  • Modellierung und Transfer von Inhalts- und Qualitätskriterien für die Programmplanung in der finanziellen Bildung im Erwachsenenalter
    P

    58.4%

• Efficacy of multidisciplinary pain treatment centers: a meta-analytic review

  1992

  Pain · 1233 Zitationen · DOI

  Sixty-five studies that evaluated the efficacy of multidisciplinary treatments for chronic back pain were included in a meta-analysis. Within- and between-group effect sizes revealed that multidisciplinary treatments for chronic pain are superior to no treatment, waiting list, as well as single-discipline treatments such as medical treatment or physical therapy. Moreover, the effects appeared to be stable over time. The beneficial effects of multidisciplinary treatment were not limited to improvements in pain, mood and interference but also extended to behavioral variables such as return to work or use of the health care system. These results tend to support the efficacy of multidisciplinary pain treatment; however, these results must be interpreted cautiously as the quality of the study designs and study descriptions is marginal. Suggestions for improvement in research designs as well as appropriate reports of research completed are provided.

• Reliability and validity of the beck anxiety inventory

  1992

  Journal of Anxiety Disorders · 774 Zitationen · DOI

• SKID II. Strukturiertes Klinisches Interview für DSM-IV, Achse II: Persönlichkeitsstörungen. Interviewheft. Eine deutschspeachige, erw. Bearb. d. amerikanischen Originalversion d. SKID-II von: M.B. First, R.L. Spitzer, M. Gibbon, J.B.W. Williams, L. Benjamin, (Version 3/96).

  1997

  Max Planck Institute for Plasma Physics · 199 Zitationen

  Author: Fydrich, T. et al.; Genre: Book; Published in Print: 1997; Title: SKID II. Strukturiertes Klinisches Interview für DSM-IV, Achse II: Persönlichkeitsstörungen. Interviewheft. Eine deutschspeachige, erw. Bearb. d. amerikanischen Originalversion d. SKID-II von: M.B. First, R.L. Spitzer, M. Gibbon, J.B.W. Williams, L. Benjamin, (Version 3/96).

• Is salivary alpha-amylase an indicator of autonomic nervous system dysregulations in mental disorders?—A review of preliminary findings and the interactions with cortisol

  2013

  Psychoneuroendocrinology · 180 Zitationen · DOI

• Behavioral assessment of social performance: a rating system for social phobia

  1998

  Behaviour Research and Therapy · 147 Zitationen · DOI

• The Validation of the German Basic Psychological Need Satisfaction and Frustration Scale in the Context of Mental Health

  2018

  European Journal of Health Psychology · 107 Zitationen · DOI

  Abstract. The primary aim of the current study was to examine the unique contribution of psychological need frustration and need satisfaction in the prediction of adults’ mental well-being and ill-being in a heterogeneous sample of adults ( N = 334; M age = 43.33, SD = 32.26; 53% females). Prior to this, validity evidence was provided for the German version of the Basic Psychological Need Satisfaction and Frustration Scale (BPNSFS) based on Self-Determination Theory (SDT). The results of the validation analyses found the German BPNSFS to be a valid and reliable measurement. Further, structural equation modeling (SEM) showed that both need satisfaction and frustration yielded unique and opposing associations with well-being. Specifically, the dimension of psychological need frustration predicted adults’ ill-being. Future research should examine whether frustration of psychological needs is involved in the onset and maintenance of psychopathology (e.g., major depressive disorder).

• Societal cost-of-illness in patients with borderline personality disorder one year before, during and after dialectical behavior therapy in routine outpatient care

  2014

  Behaviour Research and Therapy · 92 Zitationen · DOI

• Heart rate variability and its neural correlates during emotional face processing in social anxiety disorder

  2013

  Biological Psychology · 87 Zitationen · DOI

• EMOTIONAL AVAILABILITY IN MOTHER-CHILD INTERACTION: THE EFFECTS OF MATERNAL DEPRESSION IN REMISSION AND ADDITIONAL HISTORY OF CHILDHOOD ABUSE

  2015

  Depression and Anxiety · 86 Zitationen · DOI

  Our data suggest that depression impacts on maternal emotional availability during remission, which might represent a trait characteristic of depression. Mothers with depression in remission and additional severe childhood abuse were particularly affected. These findings may contribute to the understanding of children's vulnerability to develop a depressive disorder themselves.

• Shame in patients with narcissistic personality disorder

  2013

  Psychiatry Research · 82 Zitationen · DOI

• Generalized social phobia and avoidant personality disorder: meaningful distinction or useless duplication?

  2006

  Depression and Anxiety · 70 Zitationen · DOI

  Participants with generalized social phobia (GSP) with (n=36) and without (n=19) avoidant personality disorder (AVPD) were compared via contrasts of group means and classification analysis on purported core features of AVPD. GSP-AVPD participants proved to be more severely impaired or distressed on some group contrasts. Cluster analysis identified two groups in the sample, with group membership significantly correlated to AVPD diagnosis. However, almost all significant findings were nullified when severity of social phobia was statistically controlled. Thus, at least where participants with social phobia are concerned, it seems most parsimonious to consider AVPD a severe form of GSP rather than a separate diagnostic category.

• Behavioural and neural correlates of self-focused emotion regulation in social anxiety disorder

  2014

  Journal of Psychiatry and Neuroscience · 65 Zitationen · DOI

  During passive viewing of aversive images, individuals with SAD showed evidence of neural hyperreactivity that may be interpreted as increased bodily self-consciousness and heightened perspective-taking. During voluntary increase and decrease of negative emotional intensity, group differences disappeared, suggesting self-focused reappraisal as a successful emotion regulation strategy for individuals with SAD.

• Optimizing exposure-based CBT for anxiety disorders via enhanced extinction: Design and methods of a multicentre randomized clinical trial

  2017

  International Journal of Methods in Psychiatric Research · 55 Zitationen · DOI

  Exposure-based psychological interventions currently represent the empirically best established first line form of cognitive-behavioural therapy for all types of anxiety disorders. Although shown to be highly effective in both randomized clinical and other studies, there are important deficits: (1) the core mechanisms of action are still under debate, (2) it is not known whether such treatments work equally well in all forms of anxiety disorders, including comorbid diagnoses like depression, (3) it is not known whether an intensified treatment with more frequent sessions in a shorter period of time provides better outcome than distributed sessions over longer time intervals. This paper reports the methods and design of a large-scale multicentre randomized clinical trial (RCT) involving up to 700 patients designed to answer these questions. Based on substantial advances in basic research we regard extinction as the putative core candidate model to explain the mechanism of action of exposure-based treatments. The RCT is flanked by four add-on projects that apply experimental neurophysiological and psychophysiological, (epi)genetic and ecological momentary assessment methods to examine extinction and its potential moderators. Beyond the focus on extinction we also involve stakeholders and routine psychotherapists in preparation for more effective dissemination into clinical practice.

• The functional −1019C/G HTR1A polymorphism and mechanisms of fear

  2014

  Translational Psychiatry · 55 Zitationen · DOI

  Serotonin receptor 1A gene (HTR1A) knockout mice show pronounced defensive behaviour and increased fear conditioning to ambiguous conditioned stimuli. Such behaviour is a hallmark of pathological human anxiety, as observed in panic disorder with agoraphobia (PD/AG). Thus, variations in HTR1A might contribute to neurophysiological differences within subgroups of PD/AG patients. Here, we tested this hypothesis by combining genetic with behavioural techniques and neuroimaging. In a clinical multicentre trial, patients with PD/AG received 12 sessions of manualized cognitive-behavioural therapy (CBT) and were genotyped for HTR1A rs6295. In four subsamples of this multicentre trial, exposure behaviour (n=185), defensive reactivity measured using a behavioural avoidance test (BAT; before CBT: n=245; after CBT: n=171) and functional magnetic resonance imaging (fMRI) data during fear conditioning were acquired before and after CBT (n=39). HTR1A risk genotype (GG) carriers more often escaped during the BAT before treatment. Exploratory fMRI results suggest increased activation of the amygdala in response to threat as well as safety cues before and after treatment in GG carriers. Furthermore, GG carriers demonstrated reduced effects of CBT on differential conditioning in regions including the bilateral insulae and the anterior cingulate cortex. Finally, risk genotype carriers demonstrated reduced self-initiated exposure behaviour to aversive situations. This study demonstrates the effect of HTR1A variation on defensive behaviour, amygdala activity, CBT-induced neural plasticity and normalization of defence behaviour in PD/AG. Our results, therefore, translate evidence from animal studies to humans and suggest a central role for HTR1A in differentiating subgroups of patients with anxiety disorders.

• Long-term stability of cognitive behavioral therapy effects for panic disorder with agoraphobia: A two-year follow-up study

  2013

  Behaviour Research and Therapy · 54 Zitationen · DOI

• Cognitive characteristics of patients with borderline personality disorder: Development and validation of a self-report inventory

  2005

  Journal of Behavior Therapy and Experimental Psychiatry · 52 Zitationen · DOI

• Patient satisfaction with inpatient psychiatric treatment and its relation to treatment outcome in unipolar depression and schizophrenia

  2014

  International Journal of Psychiatry in Clinical Practice · 43 Zitationen · DOI

  Patient satisfaction was high without differences between MDD and schizophrenia. Severity of disease and comorbidites in MDD and number of prescribed drugs in both groups were related with reduced patient satisfaction.

• Reduced default mode network connectivity in schizophrenia patients

  2015

  Schizophrenia Research · 41 Zitationen · DOI

• Effectiveness of dialectic behavioral therapy in routine outpatient care: the Berlin Borderline Study

  2014

  Borderline Personality Disorder and Emotion Dysregulation · 41 Zitationen · DOI

  Under routine mental health care conditions in Germany, outpatient DBT leads to positive results comparable to those reported in other effectiveness studies and in randomized controlled trials.

• Neurobiological mechanisms of exercise and psychotherapy in depression: The SPeED study—Rationale, design, and methodological issues

  2017

  Clinical Trials · 39 Zitationen · DOI

  The main aims of this research project are to study effects of endurance exercise and cognitive behavioral therapy on depressive symptoms and to investigate underlying physiological and neurobiological mechanisms of these effects. Results may provide important implications for the development of effective treatment strategies in major depressive disorder, specifically concerning the augmentation of cognitive behavioral therapy by endurance exercise.

• Anticipating agoraphobic situations: the neural correlates of panic disorder with agoraphobia

  2014

  Psychological Medicine · 37 Zitationen · DOI

  This study revealed stronger region-specific activations in patients suffering from panic disorder with agoraphobia in anticipation of agoraphobia-specific stimuli. Patients seem to process these stimuli more intensively based on individual salience. Hyperactivation of the ventral striatum and insula when anticipating agoraphobia-specific situations might be a central neurofunctional correlate of agoraphobia. Knowledge about the neural correlates of anticipatory and perceptual processes regarding agoraphobic situations will help to optimize and evaluate treatments, such as exposure therapy, in patients with panic disorder and agoraphobia.

• Treating adults with a dual diagnosis of borderline personality disorder and posttraumatic stress disorder related to childhood abuse: Results from a randomized clinical trial.

  2021

  Journal of Consulting and Clinical Psychology · 36 Zitationen · DOI

  Both DBT-PTSD and CPT emerged as promising treatment options for simultaneously addressing the full spectrum of core symptoms in patients diagnosed with BPD + PTSD. Differential efficacy was in favor of DBT-PTSD as participants randomized to the DBT-PTSD arm improved more with respect to both their BPD and PTSD symptoms. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

• Running for extinction? Aerobic exercise as an augmentation of exposure therapy in panic disorder with agoraphobia

  2018

  Journal of Psychiatric Research · 34 Zitationen · DOI

• Diagnostik von Persönlichkeitsstörungen im Jugendalter nach SKID-II

  2008

  Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · 32 Zitationen · DOI

  The SCID-II - which was primarily developed for use with adults - is suitable for use among adolescents. Anorexia nervosa (binge-purging type) and ADHD/CD are closely associated with the development of PD in adolescents.

• Pretreatment Cardiac Vagal Tone Predicts Dropout from and Residual Symptoms after Exposure Therapy in Patients with Panic Disorder and Agoraphobia

  2018

  Psychotherapy and Psychosomatics · 31 Zitationen · DOI

  This publication is with permission of the rights owner freely accessible due to an alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.

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Name

Prof. Dr. Thomas Fydrich

Titel

Prof. Dr.

Fakultät

Lebenswissenschaftliche Fakultät

Institut

Institut für Psychologie

Telefon

+49 30 2093-99107

HU-FIS-Profil

Quelle ↗

Zuletzt gescrapt

26.4.2026, 01:05:01