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Prof. Kirsten Legerlotz

Kultur-, Sozial- und Bildungswissenschaftliche Fakultät · Institut für Sportwissenschaft · Movement Biomechanics (J)

Projekte

Kooperationen

Themen

Biomechanik Feldstudien Geschlechterforschung Hormonelle Verhütung Menstruationszyklus Quantitative Methoden Sportmedizin Trainingsperiodisierung Verletzungsprävention Weibliche Athleten

Zusammenfassung

Prof. Legerlotz erforscht die Auswirkungen des weiblichen Menstruationszyklus auf Sportverletzungen, Trainingsleistung und Verletzungsprävention bei Athletinnen. Ihre aktuelle Arbeit untersucht systematisch, wie Hormonzyklen, hormonelle Verhütung und Zyklusphase das Verletzungsrisiko (insbesondere ACL-Verletzungen), die Kraftleistung und die Trainierbarkeit beeinflussen — mit Fokus auf Elite-Athletinnen in Mannschaftssportarten und Gewichtheben. Durch Feldstudien mit objektiven Messverfahren (Temperaturmessung, Hormonanalyse, biomechanische Tests) entwickelt sie evidenzbasierte Erkenntnisse für zyklus-angepasste Trainingsperiodisierung und Verletzungsprävention. Die Ergebnisse sind direkt für Sportverbände, Trainerstäbe und Sportmedizin relevant, um Trainings- und Präventionsprotokolle für weibliche Athletinnen zu optimieren.

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Stammdaten

Identität, Organisation und Kontakt aus HU-FIS.

Prof. Kirsten Legerlotz

HU-FIS-Profil ↗

Fakultät: Kultur-, Sozial- und Bildungswissenschaftliche Fakultät
Institut: Institut für Sportwissenschaft
Arbeitsgruppe: Movement Biomechanics (J)
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Forschungsprojekte

GSC BSRT: JP- Movement Biomechanics
Quelle ↗
Zeitraum: 10/2014 - 10/2017 Projektleitung: Prof. Kirsten Legerlotz
Optimierung der Trainingstherapie zur Behandlung von Sportlern mit Achilles-Tendinopathie
Quelle ↗
Förderer: Bundesministerien Zeitraum: 01/2016 - 09/2018 Projektleitung: Prof. Kirsten Legerlotz
EXIST Gründerstipendium SURF ERA
Quelle ↗
Förderer: BMWE: EXIST Zeitraum: 09/2019 - 11/2020 Projektleitung: Prof. Kirsten Legerlotz

Publikationen

25Auswahl der wichtigsten Publikationen — Quelle: OpenAlex.

Increased expression of IL-6 family members in tendon pathology
2012
Lara D. Veeken · DOI
OBJECTIVES: Histological examination of pathological tendon generally does not reveal signs of inflammation. However, the inflammatory cytokine IL-6 has been shown to be expressed in ruptured rotator cuff tendon. The aim of this study was to investigate the expression of IL-6 family members in painful posterior tibialis tendon (PTT) and in painful and ruptured Achilles tendon (AT) compared with normal tendon. METHODS: AT samples were obtained from cadavers (normal) or from patients undergoing surgical procedures to treat chronic painful tendinopathy or ruptured tendon. PTT samples were obtained from patients undergoing surgery for other reasons (normal) and from patients with PTT dysfunction (painful). Total RNA was extracted and mRNA expression was analysed by quantitative real-time PCR. RESULTS: Collagen type I α-chain I (COL1A1) expression was increased in both painful PTT and AT compared with normal. Ciliary neurotrophic factor levels were increased in painful PTT only. In the painful AT, cyclooxygenase-2 (COX2) and IL-6 expression increased compared with normal. In the ruptured AT, levels of VEGF A, COX2, oncostatin-M, leukaemia inhibitory factor and IL-6 expression were higher compared with both normal and painful AT. IL-6R expression decreased in both painful and ruptured AT compared with normal. CONCLUSION: Painful AT and PTT show different expression patterns, indicating a substantial difference between those two tendinopathies. Inflammatory markers are up-regulated in painful and particularly in ruptured AT, pointing towards a role of inflammation not only in rupture healing, but also in Achilles tendinopathy.
Cyclic loading of tendon fascicles using a novel fatigue loading system increases interleukin‐6 expression by tenocytes
2011
Scandinavian Journal of Medicine and Science in Sports

Repetitive strain or 'overuse' is thought to be a major factor contributing to the development of tendinopathy. The aims of our study were to develop a novel cyclic loading system, and use it to investigate the effect of defined loading conditions on the mechanical properties and gene expression of isolated tendon fascicles. Tendon fascicles were dissected from bovine-foot extensors and subjected to cyclic tensile strain (1 Hz) at 30% or 60% of the strain at failure, for 0 h (control), 15 min, 30 min, 1 h, or 5 h. Post loading, a quasi-static test to failure assessed damage. Gene expression at a selected loading regime (1 h at 30% failure strain) was analyzed 6 h post loading by quantitative real-time polymerase chain reaction. Compared with unloaded controls, loading at 30% failure strain took 5 h to lead to a significant decrease in failure stress, whereas loading to 60% led to a significant reduction after 15 min. Loading for 1 h at 30% failure strain did not create significant structural damage, but increased Collagen-1-alpha-chain-1 and interleukin-6 (IL6) expression, suggesting a role of IL6 in tendon adaptation to exercise. Correlating failure properties with fatigue damage provides a method by which changes in gene expression can be associated with different degrees of fatigue damage.

Specimen dimensions influence the measurement of material properties in tendon fascicles

2010

Journal of Biomechanics · DOI

Stress, strain and modulus are regularly used to characterize material properties of tissue samples. However, when comparing results from different studies it is evident the reported material properties, particularly failure strains, vary hugely. The aim of our study was to characterize how and why specimen length and cross-sectional area (CSA) appear to influence failure stress, strain and modulus in fascicles from two functionally different tendons. Fascicles were dissected from five rat tails and five bovine foot extensors, their diameters determined by a laser micrometer, and loaded to failure at a range of grip-to-grip lengths. Strain to failure significantly decreased with increasing in specimen length in both rat and bovine fascicles, while modulus increased. Specimen length did not influence failure stress in rat tail fascicles, although in bovine fascicles it was significantly lower in the longer 40 mm specimens compared to 5 and 10mm specimens. The variations in failure strain and modulus with sample length could be predominantly explained by end-effects. However, it was also evident that strain fields along the sample length were highly variable and notably larger towards the ends of the sample than the mid-section even at distances in excess of 5mm from the gripping points. Failure strain, stress and modulus correlated significantly with CSA at certain specimen lengths. Our findings have implications for the mechanical testing of tendon tissue: while it is not always possible to control for fascicle length and/or CSA, these parameters have to be taken into account when comparing samples of different dimensions.

Themen

Zusammenfassung

Matches

Stammdaten

Forschungsprojekte

GSC BSRT: JP- Movement Biomechanics

Optimierung der Trainingstherapie zur Behandlung von Sportlern mit Achilles-Tendinopathie

EXIST Gründerstipendium SURF ERA

Publikationen

Increased expression of IL-6 family members in tendon pathology

Cyclic loading of tendon fascicles using a novel fatigue loading system increases interleukin‐6 expression by tenocytes

Specimen dimensions influence the measurement of material properties in tendon fascicles