Dr. rer. nat. Wolf Müller
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Forschungsthemen2
"eIDClientCore" Eine prototypische Realisierung der eID-Funktionalität als Open Source Software
Quelle ↗Zeitraum: 04/2014 - 05/2016 Projektleitung: Dr. rer. nat. Wolf Müller
"eIDClientCore"-Eine prototypische Realisierung der eID-Funktionalität als Open Source Software
Quelle ↗409 · InformatikZeitraum: 09/2012 - 09/2013 Projektleitung: Dr. rer. nat. Wolf Müller
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Stand: 26.4.2026, 19:48:44 (Top-K=20, Min-Cosine=0.4)
- 56 Treffer61.4%
- Entwicklung von wenig löslichen, homodispers nanoskopischen Metallfluoriden in Zahnzementen, Kompositfüllmaterialien und in Prophylaxepräparaten zum Einsatz im DentalbereichP61.4%
- Entwicklung von wenig löslichen, homodispers nanoskopischen Metallfluoriden in Zahnzementen, Kompositfüllmaterialien und in Prophylaxepräparaten zum Einsatz im Dentalbereich
- 52 Treffer58.3%
- FOR 5177/2: Korrelation der Leistungsfähigkeit der Lendenwirbelsäule mit klinischen Outcomes nach einer gezielten Behandlung bei Patienten mit unteren Rückenschmerzen (TP 04)P58.3%
- FOR 5177/2: Korrelation der Leistungsfähigkeit der Lendenwirbelsäule mit klinischen Outcomes nach einer gezielten Behandlung bei Patienten mit unteren Rückenschmerzen (TP 04)
- 43 Treffer57.7%
- Interfaces in opto-electronic thin film multilayer devicesP57.7%
- Interfaces in opto-electronic thin film multilayer devices
NVIDIA GmbH
PT39 Treffer57.3%- EU: Simulation in Multiscale Physical and Biological Systems (STIMULATE)P57.3%
- EU: Simulation in Multiscale Physical and Biological Systems (STIMULATE)
- 72 Treffer57.3%
- EU: Simulation in Multiscale Physical and Biological Systems (STIMULATE)P57.3%
- EU: Bottom-Up Generation of atomicalLy Precise syntheTIc 2D MATerials for High Performance in Energy and Electronic Applications – A Multi-Site Innovative Training Action (ULTIMATE)P49.8%
- EU: Simulation in Multiscale Physical and Biological Systems (STIMULATE)
- 39 Treffer57.3%
- EU: Simulation in Multiscale Physical and Biological Systems (STIMULATE)P57.3%
- EU: Simulation in Multiscale Physical and Biological Systems (STIMULATE)
- 4 Treffer55.6%
- Kompetenzzentrum Flucht, Trauma und BehinderungP55.6%
- Kompetenzzentrum Flucht, Trauma und Behinderung
- 5 Treffer55.6%
- Kompetenzzentrum Flucht, Trauma und BehinderungP55.6%
- Kompetenzzentrum Flucht, Trauma und Behinderung
- 26 Treffer55.2%
- Surface-enhanced Raman spectroscopy in liquid biopsy for breast cancerP55.2%
- Surface-enhanced Raman spectroscopy in liquid biopsy for breast cancer
- 26 Treffer55.2%
- Surface-enhanced Raman spectroscopy in liquid biopsy for breast cancerP55.2%
- Surface-enhanced Raman spectroscopy in liquid biopsy for breast cancer
Publikationen25
Top 25 nach Zitationen — Quelle: OpenAlex (BAAI/bge-m3 embedded für Matching).
Journal of Oral Implantology · 335 Zitationen · DOI
The insertion of dental implants containing titanium can be associated with various complications (eg, hypersensitivity to titanium). The aim of this article is to evaluate whether there are existing studies reporting on PEEK (polyetheretherketone) as an alternative material for dental implants. A systematic literature search of PubMed until December 2010 yielded 3 articles reporting on dental implants made from PEEK. One article analyzed stress distribution in carbon fiber-reinforced PEEK (CFR-PEEK) dental implants by the 3-dimensional finite element method, demonstrating higher stress peaks due to a reduced stiffness compared to titanium. Two articles reported on investigations in mongrel dogs. The first article compared CFR-PEEK to titanium-coated CFR-PEEK implants, which were inserted into the femurs and evaluated after 4 and 8 weeks. The titanium-coated implants showed significantly higher bone-implant contact (BIC) rates. In a second study, implants of pure PEEK were inserted into the mandibles beside implants made from titanium and zirconia and evaluated after 4 months, where PEEK presented the lowest BIC. The existing articles reporting on PEEK dental implants indicate that PEEK could represent a viable alternative material for dental implants. However, further experimental studies on the chemical modulation of PEEK seem to be necessary, mainly to increase the BIC ratio and to minimize the stress distribution to the peri-implant bone.
Biomaterials · 221 Zitationen · DOI
Clinical Oral Implants Research · 212 Zitationen · DOI
Bacterial adhesion on titanium implant surfaces has a strong influence on healing and long-term outcome of dental implants. Parameters like surface roughness and chemical composition of the implant surface were found to have a significant impact on plaque formation. The purpose of this study was to evaluate the influence of two physical hard coatings on bacterial adhesion in comparison with control surfaces of equivalent roughness. Two members of the oral microflora, Streptococcus mutans and Streptococcus sanguis were used. Commercially pure titanium discs were modified using four different surface treatments: physical vapour deposition (PVD) with either titanium nitride (TiN) or zirconium nitride (ZrN), thermal oxidation and structuring with laser radiation. Polished titanium surfaces were used as controls. Surface topography was examined by SEM and estimation of surface roughness was done using a contact stylus profilometer. Contact angle measurements were carried out to calculate surface energy. Titanium discs were incubated in the respective bacterial cell suspension for one hour and single colonies formed by adhering bacteria were counted by fluorescence microscopy. Contact angle measurements showed no significant differences between the surface modifications. The surface roughness (Ra) of all surfaces examined was between 0.14 and 1.00 microm. A significant reduction of the number of adherent bacteria was observed on inherently stable titanium hard materials such as TiN and ZrN and thermically oxidated titanium surfaces compared to polished titanium. In conclusion, physical modification of titanium implant surfaces such as coating with TiN or ZrN may reduce bacterial adherence and hence improve clinical results.
Dental Materials · 204 Zitationen · DOI
Journal of Biomechanics · 204 Zitationen · DOI
The Journal of Immunology · 143 Zitationen · DOI
We isolated a cDNA encoding a major grass pollen allergen from a timothy grass (Phleum pratense) pollen expression cDNA library using allergic patients' IgE. The complete cDNA encoded an allergen that binds IgE from about 80% of grass pollen-allergic patients. Significant sequence homology was found to other major grass pollen allergens from Kentucky bluegrass (Poa pratense) as well as from rye grass (Lolium perenne) which originally were believed to form different identities. Using different monoclonal and polyclonal antibodies raised against group V allergens we identified the recombinant protein as a group V allergen from timothy grass, Phl p V. In IgE-binding studies it is demonstrated that the rPhl p V allergen can be used to block binding of patients' IgE to natural group V isoallergens on two-dimensional immunoblots. IgE inhibition experiments show that up to 60% of grass pollenspecific IgE can be preadsorbed with the rPhl p V allergen from patients sera. The purified rPhl p V induced specific histamine release of blood basophils from grass pollen-allergic patients. This emphasizes the usefulness of the rPhl p V for diagnostic and therapeutic purposes and corroborates the view that specific diagnosis and therapy of type l allergy could be performed with a limited panel of relevant recombinant allergens.
Journal of Dentistry · 130 Zitationen · DOI
The Journal of Immunology · 110 Zitationen · DOI
One problem of conventional allergen-specific immunotherapy is the risk of anaphylactic reactions. A new approach to make immunotherapy safer and more efficient might be the application of engineered allergens with reduced IgE-binding capacity but retained T cell reactivity. Using overlapping dodeca-peptides, the dominant T cell epitopes of the timothy grass pollen allergen Phl p 5b were identified. By site-directed mutagenesis outside these regions, point and deletion mutants were generated. Allergen variants were analyzed for IgE-binding capacity with sera of different grass pollen allergic patients by Western blotting, Dot blotting, and EAST inhibition test, and for histamine releasing capacity with peripheral blood basophils from different patients. The deletion mutants revealed significantly reduced IgE reactivity and histamine releasing capacity, compared with the wild-type Phl p 5b. Furthermore, in vivo skin prick tests showed that the deletion mutants had a significantly lower potency to induce cutaneous reactions than the wild-type Phl p 5b. On the other hand, T cell clones and T cell lines from different allergic patients showed comparable proliferation after stimulation with allergen variants and wild-type Phl p 5b. Considering their reduced anaphylactogenic potential together with their conserved T cell reactivity, the engineered allergens could be important tools for efficient and safe allergen-specific immunotherapy.
Journal of Biomedical Materials Research Part A · 105 Zitationen · DOI
A major consideration in designing dental implants is the creation of a surface that provides strong attachment between the implant and bone, connective tissue, or epithelium. In addition, it is important to inhibit the adherence of oral bacteria on titanium surfaces exposed to the oral cavity to maintain plaque-free implants. Previous in vitro studies have shown that titanium implant surfaces coated with titanium nitride (TiN) reduced bacterial colonization compared to other clinically used implant surfaces. The aim of the present study was to examine the support of fibroblast growth by a TiN surface that has antimicrobial characteristics. Mouse fibroblasts were cultured on smooth titanium discs that were either magnetron-sputtered with a thin layer of titanium nitride, thermal oxidized, or modified with laser radiation (using a Nd-YAG laser). The resulting surface topography was examined by scanning electron microscopy (SEM), and surface roughness was estimated using a two-dimensional contact stylus profilometer. A protein assay (BCA assay) and a colorimetric assay to examine fibroblast metabolism (MTT) were used. Cellular morphology and cell spreading were analyzed using SEM and fluorescence microscopy. Fibroblasts on oxidized titanium surfaces showed a more spherical shape, whereas cells on laser-treated titanium and on TiN appeared intimately adherent to the surface. The MTT activity and total protein were significantly increased in fibroblasts cultured on titanium surfaces coated with TiN compared to all other surface modifications tested. This study suggests that a titanium nitride coating might be suitable to support tissue growth on implant surfaces.
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · 102 Zitationen · DOI
International Journal of Oral Science · 97 Zitationen · DOI
The aim of this study was to evaluate the effect of controlled intraoral grinding and polishing on the roughness of full-contour zirconia compared to classical veneered zirconia. Thirty bar-shaped zirconia specimens were fabricated and divided into two groups (n=15). Fifteen specimens (group 1) were glazed and 15 specimens (group 2) were veneered with feldspathic ceramic and then glazed. Prior to grinding, maximum roughness depth (Rmax) values were measured using a profilometer, 5 times per specimen. Simulated clinical grinding and polishing were performed on the specimens under water coolant for 15 s and 2 N pressure. For grinding, NTI diamonds burs with grain sizes of 20 µm, 10 µm, and 7.5 µm were used sequentially. The ground surfaces were polished using NTI kits with coarse, medium and fine polishers. After each step, Rmax values were determined. Differences between groups were examined using one-way analysis of variance (ANOVA). The roughness of group 1 was significantly lower than that of group 2. The roughness increased significantly after coarse grinding in both groups. The results after glazing were similar to those obtained after fine grinding for non-veneered zirconia. However, fine-ground veneered zirconia had significantly higher roughness than venerred, glazed zirconia. No significant difference was found between fine-polished and glazed zirconia, but after the fine polishing of veneered zirconia, the roughness was significantly higher than after glazing. It can be concluded that for full-contour zirconia, fewer defects and lower roughness values resulted after grinding and polishing compared to veneered zirconia. After polishing zirconia, lower roughness values were achieved compared to glazing; more interesting was that the grinding of glazed zirconia using the NTI three-step system could deliver smooth surfaces comparable to untreated glazed zirconia surfaces.
Parameters Influencing the Outcome of Additive Manufacturing of Tiny Medical Devices Based on PEEK
2020Materials · 87 Zitationen · DOI
In this review, we discuss the parameters of fused deposition modeling (FDM) technology used in finished parts made from polyether ether ketone (PEEK) and also the possibility of printing small PEEK parts. The published articles reporting on 3D printed PEEK implants were obtained using PubMed and search engines such as Google Scholar including references cited therein. The results indicate that although many have been experiments conducted on PEEK 3D printing, the consensus on a suitable printing parameter combination has not been reached and optimized parameters for printing worth pursuing. The printing of reproducible tiny-sized PEEK parts with high accuracy has proved to be possible in our experiments. Understanding the relationships among material properties, design parameters, and the ultimate performance of finished objects will be the basis for further improvement of the quality of 3D printed medical devices based on PEEK and to expand the polymers applications.
Dental Materials · 87 Zitationen · DOI
Journal of Allergy and Clinical Immunology · 85 Zitationen · DOI
Dental Materials · 66 Zitationen · DOI
Materials · 64 Zitationen · DOI
The indication-oriented Dental Bone Graft Substitutes (DBGS) selection, the correct bone defects classification, and appropriate treatment planning are very crucial for obtaining successful clinical results. However, hydrophilic, viscoelastic, and physicochemical properties' influence on the DBGS regenerative potential has poorly been studied. For that reason, we investigated the dimensional changes and molecular mobility by Dynamic Mechanical Analysis (DMA) of xenograft (cerabone<sup>®</sup>), synthetic (maxresorb<sup>®</sup>), and allograft (maxgraft<sup>®</sup>, Puros<sup>®</sup>) blocks in a wet and dry state. While no significant differences could be seen in dry state, cerabone<sup>®</sup> and maxresorb<sup>®</sup> blocks showed a slight height decrease in wet state, whereas both maxgraft<sup>®</sup> and Puros<sup>®</sup> had an almost identical height increase. In addition, cerabone<sup>®</sup> and maxresorb<sup>®</sup> blocks remained highly rigid and their damping behaviour was not influenced by the water. On the other hand, both maxgraft<sup>®</sup> and Puros<sup>®</sup> had a strong increase in their molecular mobility with different damping behaviour profiles during the wet state. A high-speed microscopical imaging system was used to analyze the hydrophilicity in several naturally derived (cerabone<sup>®</sup>, Bio-Oss<sup>®</sup>, NuOss<sup>®</sup>, SIC<sup>®</sup> nature graft) and synthetic DBGS granules (maxresorb<sup>®</sup>, BoneCeramic<sup>®</sup>, NanoBone<sup>®</sup>, Ceros<sup>®</sup>). The highest level of hydrophilicity was detected in cerabone<sup>®</sup> and maxresorb<sup>®</sup>, while Bio-Oss<sup>®</sup> and BoneCeramic<sup>®</sup> had the lowest level of hydrophilicity among both naturally derived and synthetic DBGS groups. Deviations among the DBGS were also addressed via physicochemical differences recorded by Micro Computed Tomography, Scanning Electron Microscopy, Fourier Transform Infrared Spectroscopy, X-ray powder Diffractometry, and Thermogravimetric Analysis. Such DBGS variations could influence the volume stability at the grafting site, handling as well as the speed of vascularization and bone regeneration. Therefore, this study initiates a new insight into the DBGS differences and their importance for successful clinical results.
Dental Materials · 59 Zitationen · DOI
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · 57 Zitationen · DOI
Dental Materials · 53 Zitationen · DOI
The hydrogen-oxygen, 2/1-mixed plasma treatment combines the effect of hydrogen and oxygen plasma which strongly improve the surface properties of PEEK implant material, such as hydrophilicity, crystallinity, surface micro-hardness and HOB cell adhesion.
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · 53 Zitationen · DOI
Advanced Engineering Materials · 52 Zitationen · DOI
Abstract Application of a biomaterial requires profound knowledge about the features and structure of the biomaterial ‐ tissue interface. Electrochemical techniques, especially electrochemical impedance spectroscopy (EIS) enable a fast non‐destructive characterization of the interface. This review summarizes the application of EIS in different biological environments.
Journal of Neuroscience Methods · 50 Zitationen · DOI
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · 48 Zitationen · DOI
Canadian Journal of Microbiology · 45 Zitationen · DOI
Ninety-five fecal samples from Atlantic cod (Gadus morhua L.), caught along the northern Norwegian coast, were examined bacteriologically for occurrence of C. perfringens. Isolates were examined by polymerase chain reaction (PCR) for genes encoding the four lethal toxins (alpha, beta, epsilon, and iota) for classification into toxin types and for genes encoding enterotoxin and the novel beta2 toxin for further subclassification. In addition, a commercial enzyme-linked immunosorbent assay (ELISA) kit for detection of C. perfringens alpha, beta, and epsilon toxin was used. Clostridium perfringens could be isolated in 37 fecal samples (38.9%) from cod. All isolates were C. perfringens toxin type A (alpha toxin positive) as determined by PCR and also ELISA. In addition, in isolates from two cod (2.1%) the gene encoding for beta2 toxin was found (A, beta2) by PCR. Genes encoding for beta, epsilon, and iota toxins and enterotoxin were not found. This is the first detection of C. perfringens alpha and beta2 toxin in cod and of beta2 toxin in fish in general. The origin of this bacterium in cod is discussed.
Biochemical Journal · 37 Zitationen · DOI
In the rat pheochromocytoma cell line PC-12, bradykinin (BK) stimulated phosphatidylinositol hydrolysis by 4-5-fold and, additionally, intracellular cAMP accumulation by approx. 1.6-fold. EC50 values for BK were 3 nM and 2 nM respectively. The BK-induced increase in cAMP accumulation was paralleled by a 1.6-fold increase in protein kinase A (PKA) activity. The time course of BK-stimulated inositol phosphate formation was rapid (t1/2<1 min), whereas the BK-induced cAMP accumulation was lagging (t1/2 approx. 6 min). The effect of BK on the cAMP pathway was independent of pertussis toxin, excluding an indirect stimulation of adenylate cyclase via betagamma-complexes from Gi or Go proteins. Two different protein kinase C (PKC) inhibitors, bisindolylmaleimide and Ro 31-820, failed to prevent BK-induced cAMP accumulation, and exclude PKC as mediator of BK action on adenylate cyclase. In contrast, the stimulatory effect of BK on cAMP accumulation was completely abolished by two calmodulin antagonists, chlorpromazine and ophiobolin, suggesting an indirect, Ca2+/calmodulin-mediated effect of BK on the cAMP pathway. In addition, exposure of PC-12 cells to BK resulted in a translocation of the PKC isoforms alpha, delta, epsilon and zeta displaying different kinetics. The BK-induced translocations of the PCDs alpha and delta were rapid and biphasic, whereas the PKCs epsilon and zeta revealed a slower and slightly transient translocation in response to BK. The BK-elicited translocation of PKCepsilon, but not that of the PKCs alpha, delta and zeta, was prevented by two different inhibitors of adenylate cyclase, 2',5'-dideoxyadenosine and MDL-12,330A, as well as the PKA inhibitor adenosine 3':5'-monophosphothioate. These findings suggest that the BK-induced translocation of novel (n)PKCepsilon is mediated via the cAMP pathway. Since nPKCepsilon appears to regulate neurite outgrowth in PC-12 cells [Hundke, McMahon, Dadgar and Messing (1995) J. Biol. Chem. 270, 30134-30140] our results provide evidence for a novel signalling mechanism that might be involved in BK-induced neuronal differentiation of PC-12 cels.
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Stammdaten
Identität, Organisation und Kontakt aus HU-FIS.
- Name
- Dr. rer. nat. Wolf Müller
- Titel
- Dr. rer. nat.
- Fakultät
- Mathematisch-Naturwissenschaftliche Fakultät
- Institut
- Institut für Informatik
- Arbeitsgruppe
- Systemarchitektur
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- +49 30 2093-41154
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- 26.4.2026, 01:09:43