Dr. rer. nat. Wolf Müller

Profil

Zusammenfassung

Dr. Wolf Müller verfügt über Expertise in der Materialwissenschaft und Oberflächenmodifikation von Dentalimplantaten, insbesondere bei der Entwicklung und Charakterisierung alternativer Implantatmaterialien wie PEEK und beschichteten Titanoberflächen. Seine Arbeiten verbinden biomechanische Analysen, Oberflächenanalytik und die Untersuchung von Wechselwirkungen zwischen Implantatmaterialien und biologischen Systemen (Bakterienadhäsion, Gewebeintegration). Daneben hat er Erfahrung in der Allergenforschung und molekularen Charakterisierung von Proteinen.

Skills

Name

Dr. rer. nat. Wolf Müller

Titel

Dr. rer. nat.

Fakultät

Mathematisch-Naturwissenschaftliche Fakultät

Institut

Institut für Informatik

Arbeitsgruppe

Systemarchitektur

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HU-FIS-Profil

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• "eIDClientCore" Eine prototypische Realisierung der eID-Funktionalität als Open Source Software

  Quelle ↗
  409-02 · Softwaretechnik und Programmiersprachen

  Zeitraum: 04/2014 - 05/2016 Projektleitung: Dr. rer. nat. Wolf Müller

• "eIDClientCore"-Eine prototypische Realisierung der eID-Funktionalität als Open Source Software

  Quelle ↗
  409 · Informatik

  Zeitraum: 09/2012 - 09/2013 Projektleitung: Dr. rer. nat. Wolf Müller

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• PEEK Dental Implants: A Review of the Literature

  2011

  Journal of Oral Implantology · 338 Zitationen · DOI

  The insertion of dental implants containing titanium can be associated with various complications (eg, hypersensitivity to titanium). The aim of this article is to evaluate whether there are existing studies reporting on PEEK (polyetheretherketone) as an alternative material for dental implants. A systematic literature search of PubMed until December 2010 yielded 3 articles reporting on dental implants made from PEEK. One article analyzed stress distribution in carbon fiber-reinforced PEEK (CFR-PEEK) dental implants by the 3-dimensional finite element method, demonstrating higher stress peaks due to a reduced stiffness compared to titanium. Two articles reported on investigations in mongrel dogs. The first article compared CFR-PEEK to titanium-coated CFR-PEEK implants, which were inserted into the femurs and evaluated after 4 and 8 weeks. The titanium-coated implants showed significantly higher bone-implant contact (BIC) rates. In a second study, implants of pure PEEK were inserted into the mandibles beside implants made from titanium and zirconia and evaluated after 4 months, where PEEK presented the lowest BIC. The existing articles reporting on PEEK dental implants indicate that PEEK could represent a viable alternative material for dental implants. However, further experimental studies on the chemical modulation of PEEK seem to be necessary, mainly to increase the BIC ratio and to minimize the stress distribution to the peri-implant bone.

• Scanning electron microscopical analysis of laser-treated titanium implant surfaces—a comparative study

  2000

  Biomaterials · 221 Zitationen · DOI

• Plaque formation on surface modified dental implants

  2001

  Clinical Oral Implants Research · 212 Zitationen · DOI

  Bacterial adhesion on titanium implant surfaces has a strong influence on healing and long-term outcome of dental implants. Parameters like surface roughness and chemical composition of the implant surface were found to have a significant impact on plaque formation. The purpose of this study was to evaluate the influence of two physical hard coatings on bacterial adhesion in comparison with control surfaces of equivalent roughness. Two members of the oral microflora, Streptococcus mutans and Streptococcus sanguis were used. Commercially pure titanium discs were modified using four different surface treatments: physical vapour deposition (PVD) with either titanium nitride (TiN) or zirconium nitride (ZrN), thermal oxidation and structuring with laser radiation. Polished titanium surfaces were used as controls. Surface topography was examined by SEM and estimation of surface roughness was done using a contact stylus profilometer. Contact angle measurements were carried out to calculate surface energy. Titanium discs were incubated in the respective bacterial cell suspension for one hour and single colonies formed by adhering bacteria were counted by fluorescence microscopy. Contact angle measurements showed no significant differences between the surface modifications. The surface roughness (Ra) of all surfaces examined was between 0.14 and 1.00 microm. A significant reduction of the number of adherent bacteria was observed on inherently stable titanium hard materials such as TiN and ZrN and thermically oxidated titanium surfaces compared to polished titanium. In conclusion, physical modification of titanium implant surfaces such as coating with TiN or ZrN may reduce bacterial adherence and hence improve clinical results.

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