Dr. rer. nat. Manuela Friedrich

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Zusammenfassung

Dr. Friedrich erforscht die neurologischen Grundlagen der frühen Sprachentwicklung und Gedächtnisbildung bei Säuglingen und Kleinkindern. Sie nutzt Elektroenzephalografie und ereigniskorrelierte Potenziale, um zu verstehen, wie das Gehirn von Neugeborenen bereits Sprache verarbeitet, Wörter lernt und Erinnerungen während des Schlafs verfestigt. Ihre Arbeiten helfen, normale Sprachentwicklung von Risikofaktoren für Sprachstörungen zu unterscheiden.

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Name

Dr. rer. nat. Manuela Friedrich

Titel

Dr. rer. nat.

Fakultät

Lebenswissenschaftliche Fakultät

Institut

Institut für Psychologie

Arbeitsgruppe

Klinische Psychologie Sozialer Interaktion

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HU-FIS-Profil

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Zuletzt gescrapt

29.6.2026, 01:06:02

• Die Anfänge episodischer Gedächtnisbildung

  Quelle ↗

  Förderer: DFG Sachbeihilfe Zeitraum: 01/2019 - 12/2022 Projektleitung: Dr. rer. nat. Manuela Friedrich

• Schlaf und Gedächtnisbildung bei Säuglingen und Kleinkindern

  Quelle ↗

  Förderer: DFG Eigene Stelle (Sachbeihilfe) Zeitraum: 01/2013 - 12/2016 Projektleitung: Dr. rer. nat. Manuela Friedrich

• Schlaf und Gedächtnisbildung bei Säuglingen und Kleinkindern II

  Quelle ↗

  Förderer: DFG Eigene Stelle (Sachbeihilfe) Zeitraum: 01/2016 - 12/2019 Projektleitung: Dr. rer. nat. Manuela Friedrich

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• Brain Responses in 4-Month-Old Infants Are Already Language Specific

  2007

  Current Biology · 242 Zitationen · DOI

• N400-like Semantic Incongruity Effect in 19-Month-Olds: Processing Known Words in Picture Contexts

  2004

  Journal of Cognitive Neuroscience · 216 Zitationen · DOI

  To understand mechanisms of early language acquisition, it is important to know whether the child's brain acts in an adult-like manner when processing words in meaningful contexts. The N400, a negative component in the eventrelated potential (ERP) of adults, is a sensitive index of semantic processing reflecting neural mechanisms of semantic integration into context. In the present study, we investigated whether the mechanisms indexed by the N400 are already working during early language acquisition. While 19-month-olds were looking at sequentially presented pictures, they were acoustically presented with words that were either congruous or incongruous to the picture content. The ERP averaged across the group of 55 children revealed an N400-like semantic incongruity effect in addition to an early phonological-lexical priming effect. The results suggest that both lexical expectations facilitating early phonological processing and mechanisms of semantic priming facilitating integration into semantic context are already present in 19-month-olds. The child's specific comprehension abilities are reflected in strength, latency, and hemispheric differences of the semantic incongruity effect. Spatio-temporal differences in that effect, thus, indicate changes in the organization of brain activity correlated with the child's behavioral development.

• Generalization of word meanings during infant sleep

  2015

  Nature Communications · 181 Zitationen · DOI

  Sleep consolidates memory and promotes generalization in adults, but it is still unknown to what extent the rapidly growing infant memory benefits from sleep. Here we show that during sleep the infant brain reorganizes recent memories and creates semantic knowledge from individual episodic experiences. Infants aged between 9 and 16 months were given the opportunity to encode both objects as specific word meanings and categories as general word meanings. Event-related potentials indicate that, initially, infants acquire only the specific but not the general word meanings. About 1.5 h later, infants who napped during the retention period, but not infants who stayed awake, remember the specific word meanings and, moreover, successfully generalize words to novel category exemplars. Independently of age, the semantic generalization effect is correlated with sleep spindle activity during the nap, suggesting that sleep spindles are involved in infant sleep-dependent brain plasticity.

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