Dr. rer. nat. Manuela Friedrich
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Forschungsthemen3
Die Anfänge episodischer Gedächtnisbildung
Quelle ↗Förderer: DFG Sachbeihilfe Zeitraum: 01/2019 - 12/2022 Projektleitung: Dr. rer. nat. Manuela Friedrich
Schlaf und Gedächtnisbildung bei Säuglingen und Kleinkindern
Quelle ↗Förderer: DFG Eigene Stelle (Sachbeihilfe) Zeitraum: 01/2013 - 12/2016 Projektleitung: Dr. rer. nat. Manuela Friedrich
Schlaf und Gedächtnisbildung bei Säuglingen und Kleinkindern II
Quelle ↗Förderer: DFG Eigene Stelle (Sachbeihilfe) Zeitraum: 01/2016 - 12/2019 Projektleitung: Dr. rer. nat. Manuela Friedrich
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Publikationen25
Top 25 nach Zitationen — Quelle: OpenAlex (BAAI/bge-m3 embedded für Matching).
Current Biology · 240 Zitationen · DOI
N400-like Semantic Incongruity Effect in 19-Month-Olds: Processing Known Words in Picture Contexts
2004Journal of Cognitive Neuroscience · 215 Zitationen · DOI
To understand mechanisms of early language acquisition, it is important to know whether the child's brain acts in an adult-like manner when processing words in meaningful contexts. The N400, a negative component in the eventrelated potential (ERP) of adults, is a sensitive index of semantic processing reflecting neural mechanisms of semantic integration into context. In the present study, we investigated whether the mechanisms indexed by the N400 are already working during early language acquisition. While 19-month-olds were looking at sequentially presented pictures, they were acoustically presented with words that were either congruous or incongruous to the picture content. The ERP averaged across the group of 55 children revealed an N400-like semantic incongruity effect in addition to an early phonological-lexical priming effect. The results suggest that both lexical expectations facilitating early phonological processing and mechanisms of semantic priming facilitating integration into semantic context are already present in 19-month-olds. The child's specific comprehension abilities are reflected in strength, latency, and hemispheric differences of the semantic incongruity effect. Spatio-temporal differences in that effect, thus, indicate changes in the organization of brain activity correlated with the child's behavioral development.
Nature Communications · 180 Zitationen · DOI
Sleep consolidates memory and promotes generalization in adults, but it is still unknown to what extent the rapidly growing infant memory benefits from sleep. Here we show that during sleep the infant brain reorganizes recent memories and creates semantic knowledge from individual episodic experiences. Infants aged between 9 and 16 months were given the opportunity to encode both objects as specific word meanings and categories as general word meanings. Event-related potentials indicate that, initially, infants acquire only the specific but not the general word meanings. About 1.5 h later, infants who napped during the retention period, but not infants who stayed awake, remember the specific word meanings and, moreover, successfully generalize words to novel category exemplars. Independently of age, the semantic generalization effect is correlated with sleep spindle activity during the nap, suggesting that sleep spindles are involved in infant sleep-dependent brain plasticity.
Neuroreport · 175 Zitationen · DOI
We recorded event-related potentials (ERPs) in 2-month-old infants in two different states of alertness: awake and asleep. Syllables varying in vowel duration (long vs short) were presented in an oddball paradigm, known to elicit a mismatch brain response. ERPs of both groups showed a mismatch response reflected in a positivity followed by a frontal negativity. While the positivity was present as a function of the stimulus type (present for long deviants only), the negativity varied as a function of the state of alertness (present for awake infants only). These data indicate a functional separation between precognitive and cognitive aspects of duration mismatch essential for the distinction between long and short vowels during early infancy.
Cognitive Brain Research · 169 Zitationen · DOI
Journal of Cognitive Neuroscience · 160 Zitationen · DOI
During their first year of life, infants not only acquire probabilistic knowledge about the phonetic, prosodic, and phonotactic organization of their native language, but also begin to establish first lexical-semantic representations. The present study investigated the sensitivity to phonotactic regularities and its impact on semantic processing in 1-year-olds. We applied the method of event-related brain potentials to 12- and 19-month-old children and to an adult control group. While looking at pictures of known objects, subjects listened to spoken nonsense words that were phonotactically legal (pseudowords) or had phonotactically illegal word onsets (nonwords), or to real words that were either congruous or incongruous to the picture contents. In 19-month-olds and in adults, incongruous words and pseudowords, but not nonwords, elicited an N400 known to ref lect mechanisms of semantic integration. For congruous words, the N400 was attenuated by semantic priming. In contrast, 12-month-olds did not show an N400 difference, neither between pseudo- and nonwords nor between incongruous and congruous words. Both 1-year-old groups and adults additionally displayed a lexical priming effect for congruous words, that is, a negativity starting around 100 msec after words onset. One-year-olds, moreover, displayed a phonotactic familiarity effect, that is, a widely distributed negativity starting around 250 msec in 19-month-olds but occurring later in 12-month-olds. The results imply that both lexical priming and phonotactic familiarity already affect the processing of acoustic stimuli in children at 12 months of age. In 19-month-olds, adult-like mechanisms of semantic integration are present in response to phonotactically legal, but not to phonotactically illegal, nonsense words, indicating that children at this age treat pseudowords, but not nonwords, as potential word candidates.
Psychophysiology · 140 Zitationen · DOI
The present study investigated whether delayed auditory processing typically found in children with specific language impairment (SLI) can already be observed in the event-related potentials of 2-month-old infants. Infants with and without a family history of SLI were tested in a passive auditory oddball paradigm with CV-syllables differing in vowel duration. For the long syllable, a positive mismatch response occurred in the difference wave between deviant and standard. Its amplitude was higher in infants during quiet sleep than in awake infants, although its peak latency remained unaffected by alertness. Awake infants showed an adultlike mismatch negativity preceding the positivity. Risk for SLI was reflected in the latency of the positive mismatch response, which was delayed in infants with risk compared to infants without risk. This latency difference suggests that 2-month-old infants at risk for SLI are already affected in processing an auditory stimulus change of duration.
Psychophysiology · 130 Zitationen · DOI
Recent developmental research on word processing has shown that mechanisms of lexical priming are already present in 12-month-olds whereas mechanisms of semantic integration indexed by the N400 mature a few months later. In a longitudinal setting we investigated whether the occurrence of an N400 at 19 months is associated with the children's language skills later on. To this end children were retrospectively grouped according to their verbal performance in a language test at 30 months. Children with later age-adequate expressive language skills already displayed an N400 at 19 months. In contrast, children with later poor expressive language skills who have an enhanced risk for the development of specific language impairment (SLI) did not show an early N400. The results imply that children who have deficits in their expressive language at the age of 30 months are already impaired in their semantic development about one year earlier.
Lexical priming and semantic integration reflected in the event-related potential of 14-month-olds
2005Neuroreport · 122 Zitationen · DOI
This study investigates by means of the event-related brain potential whether mechanisms of lexical priming and semantic integration are already developed in 14-month-olds. While looking at coloured pictures of known objects children were presented with basic-level words that were either congruous or incongruous to the pictures. The event-related potential of 14-month-olds revealed an early negativity in the lateral frontal brain region for congruous words, and a later N400-like negativity for incongruous words. These results indicate that both lexical priming and semantic integration are already present as early as 14 months.
Journal of Cognitive Neuroscience · 103 Zitationen · DOI
There has been general consensus that initial word learning during early infancy is a slow and time-consuming process that requires very frequent exposure, whereas later in development, infants are able to quickly learn a novel word for a novel meaning. From the perspective of memory maturation, this shift in behavioral development might represent a shift from slow procedural to fast declarative memory formation. Alternatively, it might be caused by the maturation of specific brain structures within the declarative memory system that may support lexical mapping from the very first. Here, we used the neurophysiological method of ERPs to watch the brain activity of 6-month-old infants, when repeatedly presented with object-word pairs in a cross-modal learning paradigm. We report first evidence that infants as young as 6 months are able to associate objects and words after only very few exposures. A memory test 1 day later showed that infants did not fully forget this newly acquired knowledge, although the ERP effects indicated it to be less stable than immediately after encoding. The combined results suggest that already at 6 months the encoding process of word learning is based on fast declarative memory formation, but limitations in the consolidation of declarative memory diminish the long lasting effect in lexical-semantic memory at that age.
NeuroImage · 103 Zitationen · DOI
Neuroreport · 99 Zitationen · DOI
Between 12 and 14 months infants switch from slow to fast word learning mode. The neural processes involved in this development are largely unknown. This study explored the brain activity related to the fast learning of object-word mappings in 14-month-old infants. After four repetitions of eight object-word pairs, two priming effects known from earlier infant event-related potential studies were observed: word form priming indexed by the fronto-lateral negativity in the 200-500 ms range and semantic priming indexed by the parietal N400. These neurophysiological correlates suggest that infants have learned object-word mappings by four presentations. In a test phase applied at least 1 day later, the N400 differentiated between trained congruous and incongruous pairings, which indicates that this newly established referential knowledge has been consolidated in memory.
Cognitive Brain Research · 87 Zitationen · DOI
Brain and Language · 86 Zitationen · DOI
Journal of Cognitive Neuroscience · 82 Zitationen · DOI
Event-related brain potential (ERP) studies of sentence processing in adults have shown that phrase-structure violations are associated with two ERP components: an early left anterior negativity (ELAN) and a late, centro-parietal positivity (P600). Although the ELAN reflects highly automatic first-pass sentence parsing, the P600 has been interpreted to reflect later, more controlled processes. The present ERP study investigates the processing of phrase-structure violations in children below three years of age. Both children (mean age of 2.8 years) and adults passively listened to short active sentences that were either correct or syntactically incorrect. Adults displayed an ELAN that was followed by a P600 to the syntactic violation. Children also demonstrated a biphasic ERP pattern consisting of an early left hemispheric negativity and a late positivity. Both components, however, started later and persisted longer than those observed in adults. The left lateralization of the children's negativity suggests that this component can be interpreted as a child-specific precursor to the ELAN observed in adults. The appearance of the early negativity indicates that the neural mechanisms of syntactic parsing are present, in principle, during early language development.
Current Biology · 79 Zitationen · DOI
Journal of Biological Chemistry · 77 Zitationen · DOI
For the surveillance of transmissible spongiform encephalopathies (TSEs) in animals and humans, the discrimination of different TSE strains causing scrapie, BSE, or Creutzfeldt-Jakob disease constitutes a substantial challenge. We addressed this problem by Fourier transform-infrared (FT-IR) spectroscopy of pathological prion protein PrP27-30. Different isolates of hamster-adapted scrapie (263K, 22A-H, and ME7-H) and BSE (BSE-H) were passaged in Syrian hamsters. Two of these agents, 22A-H and ME7-H, caused TSEs with indistinguishable clinical symptoms, neuropathological changes, and electrophoretic mobilities and glycosylation patterns of PrP27-30. However, FT-IR spectroscopy revealed that PrP27-30 of all four isolates featured different characteristics in the secondary structure, allowing a clear distinction between the passaged TSE agents. FT-IR analysis showed that phenotypic information is mirrored in beta-sheet and other secondary structure elements of PrP27-30, also in cases where immunobiochemical typing failed to detect structural differences. If the findings of this study hold true for nonexperimental TSEs in animals and humans, FT-IR characterization of PrP27-30 may provide a versatile tool for molecular strain typing without antibodies and without restrictions to specific TSEs or mammalian species.
Cortex · 75 Zitationen · DOI
Neuroreport · 72 Zitationen · DOI
The present study used the N400, an electrophysiological correlate of semantic processing, to investigate 19- and 24-month-old children's ability to integrate the meaning of words in a sentential context. Children listened passively to semantically appropriate sentences and to sentences in which the object noun violates the selection restriction of the verb. The event-related potentials of both age groups revealed an N400 on inappropriate object nouns. This indicates that the children are able to semantically integrate words into sentence contexts. Furthermore, the result implies that selection restrictions are part of the children's first verb representations.
Nature Communications · 50 Zitationen · DOI
Any experienced event may be encoded and retained in detail as part of our episodic memory, and may also refer and contribute to our generalized knowledge stored in semantic memory. The beginnings of this declarative memory formation are only poorly understood. Even less is known about the interrelation between episodic and semantic memory during the earliest developmental stages. Here, we show that the formation of episodic memories in 14- to 17-month-old infants depends on sleep, subsequent to exposure to novel events. Infant brain responses reveal that, after sleep-dependent consolidation, the newly stored events are not processed semantically, although appropriate lexical-semantic memories are present and accessible by similar events that were not experienced before the nap. We propose that temporarily disabled semantic processing protects precise episodic memories from interference with generalized semantic memories. Selectively restricted semantic access could also trigger semantic refinement, and thus, might even improve semantic memory.
Developmental Science · 46 Zitationen · DOI
The present study explored the origins of word learning in early infancy. Using event-related potentials (ERP) we monitored the brain activity of 3-month-old infants when they were repeatedly exposed to several initially novel words paired consistently with each the same initially novel objects or inconsistently with different objects. Our results provide strong evidence that these young infants extract statistic regularities in the distribution of the co-occurrences of objects and words extremely quickly. The data suggest that this ability is based on the rapid formation of associations between the neural representations of objects and words, but that the new associations are not retained in long-term memory until the next day. The type of brain response moreover indicates that, unlike in older infants, in 3-month-olds a semantic processing stage is not involved. Their ability to combine words with meaningful information is caused by a primary learning mechanism that enables the formation of proto-words and acts as a precursor for the acquisition of genuine words.
Developmental Science · 41 Zitationen · DOI
Sleep spindle activity in infants supports their formation of generalized memories during sleep, indicating that specific sleep processes affect the consolidation of memories early in life. Characteristics of sleep spindles depend on the infant's developmental state and are known to be associated with trait-like factors such as intelligence. It is, however, largely unknown which state-like factors affect sleep spindles in infancy. By varying infants' wake experience in a within-subject design, here we provide evidence for a learning- and memory-dependent modulation of infant spindle activity. In a lexical-semantic learning session before a nap, 14- to 16-month-old infants were exposed to unknown words as labels for exemplars of unknown object categories. In a memory test on the next day, generalization to novel category exemplars was tested. In a nonlearning control session preceding a nap on another day, the same infants heard known words as labels for exemplars of already known categories. Central-parietal fast sleep spindles increased after the encoding of unknown object-word pairings compared to known pairings, evidencing that an infant's spindle activity varies depending on its prior knowledge for newly encoded information. Correlations suggest that enhanced spindle activity was particularly triggered, when similar unknown pairings were not generalized immediately during encoding. The spindle increase triggered by previously not generalized object-word pairings, moreover, boosted the formation of generalized memories for these pairings. Overall, the results provide first evidence for a fine-tuned regulation of infant sleep quality according to current consolidation requirements, which improves the infant long-term memory for new experiences.
Psychophysiology · 20 Zitationen · DOI
The influence of levels of abstraction in picture-word matching was examined. The items each consisted of one picture and three successively presented words. Hierarchies with words for superordinate, basic, and subordinate level concepts were used (e.g., plant, flower, rose). The picture-word condition (congruent, incongruent), the word position (first, second, third), and the level of categorization (subordinate, basic, superordinate) were manipulated. Reaction times, error rates, and pupillary responses were recorded. Pupillary responses coincided with behavioral data. In general, there was an advantage for subordinate and basic level processing compared to superordinate level processing. However, switches to words for superordinate concepts were most facilitated. These findings support a two-step account of picture-word matching. First, the picture is categorized according to its concrete features. Second, amodal features are processed.
Trends in language acquisition research · 18 Zitationen · DOI
The Journal of the Acoustical Society of America · 17 Zitationen · DOI
Cross-sectional pressure distributions, natural acoustic modes, and associated cutoff frequencies are determined for real ear-canal geometries using an asymptotic theory in combination with a numerical method. The technique is particularly well suited to obtain the higher modes, which are trapped near both ends of the ear canal. Results detail the influence of the canal geometry and frequency on the spatial distribution of the pressure. Adult ear-canal geometries are determined near the concha from ear-mold sections using a light microscope interfaced to a video-data-acquisition system. Computed results compare favorably to the exact solutions for circular and square acoustic waveguides. The cutoff frequency of the two adult ear canals studied averaged 20% less than the cutoff frequency of a circular tube of identical cross-sectional area. Inserting a probe microphone into the canal decreases the rate of decay of circumferential nonplanar modes while increasing the rate of decay of radial modes. Relative to the pressure beyond the tube, insertion increases the plane-wave component of the pressure around the tube by a multiplicative factor approximately equal to the square root of the original area divided by the occluded area. Eccentric placement of the probe tube has a relatively small influence on the cutoff frequency. The transition of the pressure distribution at the entrance to a simple plane wave in the core region of the canal is calculated and shown graphically for the actual geometry of two adult subjects.
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Stammdaten
Identität, Organisation und Kontakt aus HU-FIS.
- Name
- Dr. rer. nat. Manuela Friedrich
- Titel
- Dr. rer. nat.
- Fakultät
- Lebenswissenschaftliche Fakultät
- Institut
- Institut für Psychologie
- Arbeitsgruppe
- Klinische Psychologie
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- +49 30 2093-9476
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