Prof. Dr. Sebastian Markett
Profil
Forschungsthemen2
Konnektom und Kognition
Quelle ↗Förderer: DFG Sachbeihilfe Zeitraum: 05/2018 - 07/2024 Projektleitung: Prof. Dr. Sebastian Markett
Neurotizismus verstehen durch Integration von Genetik und struktureller Gehirnnetzwerk-Konnektivität
Quelle ↗Förderer: DFG Sachbeihilfe Zeitraum: 01/2026 - 12/2028 Projektleitung: Prof. Dr. Sebastian Markett
Mögliche Industrie-Partner10
Stand: 26.4.2026, 19:48:44 (Top-K=20, Min-Cosine=0.4)
- 101 Treffer56.3%
- SFB 1315/2: Mechanismen und Störungen der Gedächtniskonsolidierung: Von Synapsen zur SystemebeneP56.3%
- DFG-Sachbeihilfe: Aufmerksamkeit und sensorische Integration im aktiven Sehen von bewegten ObjektenT52.8%
- SFB 1315/2: Mechanismen und Störungen der Gedächtniskonsolidierung: Von Synapsen zur Systemebene
- 33 Treffer55.3%
- Bewertung der physiologischen Plastizität und genetischen Variabilität der Kiefer (Pinus sylvestris L.) an ihrer westlichen Verbreitungsgrenze unter den Bedingungen des KlimawandelsP55.3%
- Bewertung der physiologischen Plastizität und genetischen Variabilität der Kiefer (Pinus sylvestris L.) an ihrer westlichen Verbreitungsgrenze unter den Bedingungen des Klimawandels
- 5 Treffer55.0%
- Zuwendung im Rahmen des Programms „exist – Existenzgründungen aus der Wissenschaft“ aus dem Bundeshaushalt, Einzelplan 09, Kapitel 02, Titel 68607, Haushaltsjahr 2026, sowie aus Mitteln des Europäischen Strukturfonds (hier Euro-päischer Sozialfonds Plus – ESF Plus) Förderperiode 2021-2027 – Kofinanzierung für das Vorhaben: „exist Women“T55.0%
- Zuwendung im Rahmen des Programms „exist – Existenzgründungen aus der Wissenschaft“ aus dem Bundeshaushalt, Einzelplan 09, Kapitel 02, Titel 68607, Haushaltsjahr 2026, sowie aus Mitteln des Europäischen Strukturfonds (hier Euro-päischer Sozialfonds Plus – ESF Plus) Förderperiode 2021-2027 – Kofinanzierung für das Vorhaben: „exist Women“
- 2 Treffer54.8%
- Generalized Quatum Batalin-Vilkovisky Formalism and Graphical CalculusP54.8%
- Generalized Quatum Batalin-Vilkovisky Formalism and Graphical Calculus
- 69 Treffer54.6%
- Promoting Deaf and Hard of Hearing Children's Theory of Mind and Emotion UnderstandingP54.6%
- Promoting Deaf and Hard of Hearing Children's Theory of Mind and Emotion Understanding
- Promoting Deaf and Hard of Hearing Children's Theory of Mind and Emotion UnderstandingP54.6%
- Promoting Deaf and Hard of Hearing Children's Theory of Mind and Emotion Understanding
- 71 Treffer54.6%
- Promoting Deaf and Hard of Hearing Children's Theory of Mind and Emotion UnderstandingP54.6%
- Promoting Deaf and Hard of Hearing Children's Theory of Mind and Emotion Understanding
- 70 Treffer54.6%
- Promoting Deaf and Hard of Hearing Children's Theory of Mind and Emotion UnderstandingP54.6%
- Promoting Deaf and Hard of Hearing Children's Theory of Mind and Emotion Understanding
- 69 Treffer54.6%
- Promoting Deaf and Hard of Hearing Children's Theory of Mind and Emotion UnderstandingP54.6%
- Promoting Deaf and Hard of Hearing Children's Theory of Mind and Emotion Understanding
- 54 Treffer54.2%
- Design & Implementierung eines neuronalen Netzwerks für die Personendetektion (Transferbonus)T54.2%
- Design & Implementierung eines neuronalen Netzwerks für die Personendetektion (Transferbonus)
Publikationen25
Top 25 nach Zitationen — Quelle: OpenAlex (BAAI/bge-m3 embedded für Matching).
Asia-Pacific Psychiatry · 344 Zitationen · DOI
In general, it is of importance to distinguish between generalized and specific Internet addiction.
Human Brain Mapping · 143 Zitationen · DOI
In the recent past, various intrinsic connectivity networks (ICN) have been identified in the resting brain. It has been hypothesized that the fronto-parietal ICN is involved in attentional processes. Evidence for this claim stems from task-related activation studies that show a joint activation of the implicated brain regions during tasks that require sustained attention. In this study, we used functional magnetic resonance imaging (fMRI) to demonstrate that functional connectivity within the fronto-parietal network at rest directly relates to attention. We applied graph theory to functional connectivity data from multiple regions of interest and tested for associations with behavioral measures of attention as provided by the attentional network test (ANT), which we acquired in a separate session outside the MRI environment. We found robust statistical associations with centrality measures of global and local connectivity of nodes within the network with the alerting and executive control subfunctions of attention. The results provide further evidence for the functional significance of ICN and the hypothesized role of the fronto-parietal attention network.
Behavioural Brain Research · 132 Zitationen · DOI
Frontiers in Systems Neuroscience · 120 Zitationen · DOI
Jeffrey Gray's Reinforcement Sensitivity Theory (RST) represents one of the most influential biologically-based personality theories describing individual differences in approach and avoidance tendencies. The most prominent self-report inventory to measure individual differences in approach and avoidance behavior to date is the BIS/BAS scale by Carver and White (1994). As Gray and McNaughton (2000) revised the RST after its initial formulation in the 1970/80s, and given the Carver and White measure is based on the initial conceptualization of RST, there is a growing need for self-report inventories measuring individual differences in the revised behavioral inhibition system (BIS), behavioral activation system (BAS) and the fight, flight, freezing system (FFFS). Therefore, in this paper we present a new questionnaire measuring individual differences in the revised constructs of the BIS, BAS and FFFS in N = 1814 participants (German sample). An English translated version of the new measure is also presented and tested in N = 299 English language participants. A large number of German participants (N = 1090) also filled in the BIS/BAS scales by Carver and White (1994) and the correlations between these measures are presented. Finally, this same subgroup of participants provided buccal swaps for the investigation of the arginine vasopressin receptor 1a (AVPR1a) gene. Here, a functional genetic polymorphism (rs11174811) on the AVPR1a gene was shown to be associated with individual differences in both the revised BIS and classic BIS dimensions.
Social Cognitive and Affective Neuroscience · 119 Zitationen · DOI
Findings from twin studies yield heritability estimates of 0.50 for prosocial behaviours like empathy, cooperativeness and altruism. First molecular genetic studies underline the influence of polymorphisms located on genes coding for the receptors of the neuropeptides, oxytocin and vasopressin. However, the proportion of variance explained by these gene loci is rather low indicating that additional genetic variants must be involved. Pharmacological studies show that the dopaminergic system interacts with oxytocin and vasopressin. The present experimental study tests a dopaminergic candidate polymorphism for altruistic behaviour, the functional COMT Val158Met SNP. N = 101 healthy Caucasian subjects participated in the study. Altruism was assessed by the amount of money donated to a poor child in a developing country, after having earned money by participating in two straining computer experiments. Construct validity of the experimental data was given: the highest correlation between the amount of donations and personality was observed for cooperativeness (r = 0.32, P ≤ 0.001). Carriers of at least one Val allele donated about twice as much money as compared with those participants without a Val allele (P = 0.01). Cooperativeness and the Val allele of COMT additively explained 14.6% of the variance in donation behaviour. Results indicate that the Val allele representing strong catabolism of dopamine is related to altruism.
Personality and Individual Differences · 109 Zitationen · DOI
Neuroreport · 107 Zitationen · DOI
The present study focuses on the neurostructural foundations of the human personality. In a large sample of 227 healthy human individuals (168 women and 59 men), we used MRI to examine the relationship between personality traits and both regional gray and white matter volume, while controlling for age and sex. Personality was assessed using the German version of the NEO Five-Factor Inventory that measures individual differences in the 'Big Five of Personality': extraversion, neuroticism, agreeableness, conscientiousness, and openness to experience. In contrast to most previous studies on neural correlates of the Big Five, we used improved processing strategies: white and gray matter were independently assessed by segmentation steps before data analysis. In addition, customized sex-specific diffeomorphic anatomical registration using exponentiated lie algebra templates were used. Our results did not show significant correlations between any dimension of the Big Five and regional gray matter volume. However, among others, higher conscientiousness scores correlated significantly with reductions in regional white matter volume in different brain areas, including the right insula, putamen, caudate, and left fusiformis. These correlations were driven by the female subsample. The present study suggests that many results from the literature on the neurostructural basis of personality should be reviewed carefully, considering the results when the sample size is larger, imaging methods are rigorously applied, and sex-related and age-related effects are controlled.
Biological Psychology · 106 Zitationen · DOI
Journal of Media Psychology Theories Methods and Applications · 95 Zitationen · DOI
The present study investigated the influence on Internet addiction of numerous variables ranging from personality to psychological and physical well-being, in a large and highly ecologically valid sample of mainly male adolescent online computer gamers (first-person-shooter video gamers) in Germany. Low Self-Directedness could be linked to a high Internet Addiction Test score in the present study, and the data yielded a continuum model indicating that low Self-Directedness is highly correlated with Internet Addiction Score, not only in students but also in first-person-shooter video gamers.
Reviews in the Neurosciences · 93 Zitationen · DOI
The emotion of anxiety represents one of the most studied topics in the neurosciences, in part due to its relevance for understanding the evolutionary development of the human brain and its role in the pathogenesis of psychopathological conditions. Structural magnetic resonance imaging (sMRI) has enabled mapping of the anxious human brain and has contributed substantially to the understanding of anxiety. Alongside the fields of clinical psychology/psychiatry, personality psychology aims to support the research endeavor of mapping the anxious brain and has found that individual differences in anxiety-related personality dimensions such as Neuroticism or Harm Avoidance (measured by self-report) are correlated with gray and white matter volumes in different areas of the human brain. This review reveals that structures including parts of the frontal cortex (e.g., the orbitofrontal cortex) and the temporal lobe (e.g., the hippocampus) are often associated with trait anxiety, and it points out the inconsistencies that exist in the personality-sMRI literature on human anxiety. Consequently, we suggest new research strategies to overcome the inconsistencies. This review outlines how results from animal research can guide scientists in developing testable hypotheses in search of the anxious brain. Moreover, genetic imaging is presented as an interesting approach to mapping the anxious brain.
Journal of Addiction Medicine · 93 Zitationen · DOI
Recent studies from Asia provided first evidence for a molecular genetic link between serotonergic and dopaminergic neurotransmission and Internet addiction. The present report offers data on a new candidate gene in the investigation of Internet addiction-the gene coding for the nicotinic acetylcholine receptor subunit alpha 4 (CHRNA4). A case-control study was carried out. The participants were recruited from a large gene data bank, including people from the general population and from a university setting. A total of 132 participants with problematic Internet use and 132 age- and sex-matched controls participated in the study. Participants provided DNA samples and filled in the Internet Addiction Test Questionnaire. The T- variant (CC genotype) of the rs1044396 polymorphism on the CHRNA4 gene occurred significantly more frequently in the case group. Further analyses revealed that this effect was driven by females. Combined with the findings from other studies, the present data point in the direction that rs1044396 exerts pleiotropic effects on a vast range of behaviors, including cognition, emotion, and addiction.
NeuroImage · 76 Zitationen · DOI
Cognitive Neuropsychiatry · 76 Zitationen · DOI
The questionnaire measures of empathy seem valid and exchangeable, and therefore suitable for capturing self-reported empathy in clinical research. The behavioural paradigms cover distinct endophenotypes of empathy and should only be used for very specific research questions.
Neuroscience · 76 Zitationen · DOI
eLife · 72 Zitationen · DOI
Human neuroscience has always been pushing the boundary of what is measurable. During the last decade, concerns about statistical power and replicability - in science in general, but also specifically in human neuroscience - have fueled an extensive debate. One important insight from this discourse is the need for larger samples, which naturally increases statistical power. An alternative is to increase the precision of measurements, which is the focus of this review. This option is often overlooked, even though statistical power benefits from increasing precision as much as from increasing sample size. Nonetheless, precision has always been at the heart of good scientific practice in human neuroscience, with researchers relying on lab traditions or rules of thumb to ensure sufficient precision for their studies. In this review, we encourage a more systematic approach to precision. We start by introducing measurement precision and its importance for well-powered studies in human neuroscience. Then, determinants for precision in a range of neuroscientific methods (MRI, M/EEG, EDA, Eye-Tracking, and Endocrinology) are elaborated. We end by discussing how a more systematic evaluation of precision and the application of respective insights can lead to an increase in reproducibility in human neuroscience.
Addiction Biology · 70 Zitationen · DOI
Internet gaming disorder represents a growing health issue. Core symptoms include unsuccessful attempts to control the addictive patterns of behavior and continued use despite negative consequences indicating a loss of regulatory control. Previous studies revealed brain structural deficits in prefrontal regions subserving regulatory control in individuals with excessive Internet use. However, because of the cross-sectional nature of these studies, it remains unknown whether the observed brain structural deficits preceded the onset of excessive Internet use. Against this background, the present study combined a cross-sectional and longitudinal design to determine the consequences of excessive online video gaming. Forty-one subjects with a history of excessive Internet gaming and 78 gaming-naive subjects were enrolled in the present study. To determine effects of Internet gaming on brain structure, gaming-naive subjects were randomly assigned to 6 weeks of daily Internet gaming (training group) or a non-gaming condition (training control group). At study inclusion, excessive Internet gamers demonstrated lower right orbitofrontal gray matter volume compared with Internet gaming-naive subjects. Within the Internet gamers, a lower gray matter volume in this region was associated with higher online video gaming addiction severity. Longitudinal analysis revealed initial evidence that left orbitofrontal gray matter volume decreased during the training period in the training group as well as in the group of excessive gamers. Together, the present findings suggest an important role of the orbitofrontal cortex in the development of Internet addiction with a direct association between excessive engagement in online gaming and structural deficits in this brain region.
Neuroscience & Biobehavioral Reviews · 69 Zitationen · DOI
"Executive functions" (EFs) is an umbrella term for higher cognitive control functions such as working memory, inhibition, and cognitive flexibility. One of the most challenging problems in this field of research has been to explain how the wide range of cognitive processes subsumed as EFs are controlled without an all-powerful but ill-defined central executive in the brain. Efforts to localize control mechanisms in circumscribed brain regions have not led to a breakthrough in understanding how the brain controls and regulates itself. We propose to re-conceptualize EFs as emergent consequences of highly distributed brain processes that communicate with a pool of highly connected hub regions, thus precluding the need for a central executive. We further discuss how graph-theory driven analysis of brain networks offers a unique lens on this problem by providing a reference frame to study brain connectivity in EFs in a holistic way and helps to refine our understanding of the mechanisms underlying EFs by providing new, testable hypotheses and resolves empirical and theoretical inconsistencies in the EF literature.
NeuroImage · 68 Zitationen · DOI
Journal of Cognitive Neuroscience · 66 Zitationen · DOI
Working memory capacity is extremely limited and individual differences are heritable to a considerable extent. In the search for a better understanding of the exact genetic underpinnings of working memory, most research has focused on functional gene variants involved in the metabolism of the neurotransmitter dopamine. Recently, there has been investigation of genes related to other neurotransmitter systems such as acetylcholine. The potential relevance of a polymorphism located in the gene coding for the alpha4 subunit of the nicotinic acetylcholine receptor (rs#1044396) has been discussed with respect to working memory, but empirical investigations have provided mixed results. However, pharmacological studies in both rodents and humans have shown that the effect of nicotinic agonists on cognitive functions is mediated by dopamine. We therefore hypothesized that such an interaction can be found on a molecular genetic level as well. In order to test this hypothesis, we genotyped 101 healthy subjects for rs#1044396 and three functional polymorphisms on the dopamine d2 receptor gene (rs#1800497, rs#6277, rs#2283265). These subjects performed a visuospatial working memory task in which memory load was systematically varied. We found a significant interaction between rs#1044396 and a haplotype block covering all three dopaminergic polymorphisms on working memory capacity. This effect only became apparent on higher levels of working memory load. This is the first evidence from a molecular genetic perspective that these two neurotransmitter systems interact on cognitive functioning. The results are discussed with regard to their implication for working memory theories and their clinical relevance for treatment of substance abuse and schizophrenia.
Personality Neuroscience · 64 Zitationen · DOI
Personality and individual differences originate from the brain. Despite major advances in the affective and cognitive neurosciences, however, it is still not well understood how personality and single personality traits are represented within the brain. Most research on brain-personality correlates has focused either on morphological aspects of the brain such as increases or decreases in local gray matter volume, or has investigated how personality traits can account for individual differences in activation differences in various tasks. Here, we propose that personality neuroscience can be advanced by adding a network perspective on brain structure and function, an endeavor that we label personality network neuroscience. With the rise of resting-state functional magnetic resonance imaging (MRI), the establishment of connectomics as a theoretical framework for structural and functional connectivity modeling, and recent advancements in the application of mathematical graph theory to brain connectivity data, several new tools and techniques are readily available to be applied in personality neuroscience. The present contribution introduces these concepts, reviews recent progress in their application to the study of individual differences, and explores their potential to advance our understanding of the neural implementation of personality. Trait theorists have long argued that personality traits are biophysical entities that are not mere abstractions of and metaphors for human behavior. Traits are thought to actually exist in the brain, presumably in the form of conceptual nervous systems. A conceptual nervous system refers to the attempt to describe parts of the central nervous system in functional terms with relevance to psychology and behavior. We contend that personality network neuroscience can characterize these conceptual nervous systems on a functional and anatomical level and has the potential do link dispositional neural correlates to actual behavior.
Brain and Cognition · 64 Zitationen · DOI
Human Brain Mapping · 59 Zitationen · DOI
Attention network theory distinguishes three independent systems, each supported by its own distributed network: an alerting network to deploy attentional resources in anticipation, an orienting network to direct attention to a cued location, and a control network to select relevant information at the expense of concurrently available information. Ample behavioral and neuroimaging evidence supports the dissociation of the three attention domains. The strong assumption that each attentional system is realized through a separable network, however, raises the question how these networks relate to the intrinsic network structure of the brain. Our understanding of brain networks has advanced majorly in the past years due to the increasing focus on brain connectivity. The brain is intrinsically organized into several large-scale networks whose modular structure persists across task states. Existing proposals on how the presumed attention networks relate to intrinsic networks rely mostly on anecdotal and partly contradictory arguments. We addressed this issue by mapping different attention networks at the level of cifti-grayordinates. Resulting group maps were compared to the group-level topology of 23 intrinsic networks, which we reconstructed from the same participants' resting state fMRI data. We found that all attention domains recruited multiple and partly overlapping intrinsic networks and converged in the dorsal fronto-parietal and midcingulo-insular network. While we observed a preference of each attentional domain for its own set of intrinsic networks, implicated networks did not match well to those proposed in the literature. Our results indicate a necessary refinement of the attention network theory.
Neuropsychopharmacology · 59 Zitationen · DOI
Neuroscience · 58 Zitationen · DOI
Brain and Behavior · 56 Zitationen · DOI
Although prominent personality theories postulate orthogonality between traits of positive emotionality (PEM) and negative emotionality (NEM), empirical evidence often demonstrates the opposite indicating a negative relationship. Therefore, it is not surprising that dopaminergic (DA) gene loci have been related to traits of positive and of NEM. The present genetic association study investigates the influence of two functional DA gene polymorphisms on Sadness as defined by the Affective Neuroscience Personality Scales (ANPS) in healthy Caucasians (n = 1041). We observed a significant interaction effect between the 10-repeat (10R) allele of the dopamine transporter (DAT1) gene and the methionine (Met) allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism (F((1,1018)) = 11.11; P < 0.001). Carriers of the 9R/9R and the Val/Val genotype showed dramatically reduced Sadness scores in comparison to the other three genotype configurations. Both the 9R/9R and the Val/Val genotypes characterized by reduced transporter density and high dopamine catabolism, respectively, have been separately related to personality traits of PEM and externalizing behavior in the past. The present findings indicate that gene variations of the DA system previously associated with PEM are at the same time protective against high NEM and can therefore constitute a resilience factor against depression.
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Stammdaten
Identität, Organisation und Kontakt aus HU-FIS.
- Name
- Prof. Dr. Sebastian Markett
- Titel
- Prof. Dr.
- Fakultät
- Lebenswissenschaftliche Fakultät
- Institut
- Institut für Psychologie
- Arbeitsgruppe
- Molekulare Psychologie (J)
- Telefon
- +49 30 2093-98962
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- 26.4.2026, 01:08:59