Prof. Kneipp erforscht oberflächenverstärkte Raman-Spektroskopie (SERS) und verwandte optische Techniken zur molekularen Charakterisierung von biologischen Proben und Nanomaterialien. Ihr aktueller Fokus liegt auf der Anwendung von SERS und Nano-Infrarot-Spektroskopie für die Analyse von Zellen, Enzymen und Biomolekülen in ihrer natürlichen Umgebung — etwa zur Früherkennung von Brustkrebs oder zur Untersuchung von Enzymnetzwerken in situ. Sie entwickelt zudem nichtlineare optische Prozesse (wie Zwei-Photonen-Raman-Spektroskopie) an plasmonischen Nanostrukturen, um strukturelle und funktionale Information mit höchster räumlicher Auflösung zu gewinnen. Diese Technologien ermöglichen es Unternehmen und Forschungseinrichtungen, Biomoleküle und Zellkomponenten schnell und sensitiv zu identifizieren — relevant für Diagnostik, Qualitätskontrolle in der Pharmazie und Materialwissenschaft sowie für die Grundlagenforschung in Katalyse und Zellbiologie.
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Prof. Dr. rer. nat. Janina Kneipp
HU-FIS-Profil ↗DYnamic control in hybrid plasmonic NAnopores: road to next generation multiplexed single MOlecule detection
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Surface-enhanced Raman spectroscopy in liquid biopsy for breast cancer
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Surface-enhanced Raman spectroscopy in liquid biopsy for breast cancer
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Silica incorporation into newly synthesized cell walls and its effects on physiological properties of plant cells
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DYnamic control in hybrid plasmonic NAnopores: road to next generation multiplexed single MOlecule detection
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EXC 2008: Unifying Systems in Catalysis (UniSysCat)
university
Förderer: DFG Sachbeihilfe Zeitraum: 10/2008 - 07/2014 Projektleitung: Prof. Dr. rer. nat. Janina Kneipp
Zeitraum: 01/2011 - 12/2015 Projektleitung: Prof. Dr. rer. nat. Janina Kneipp
Förderer: Einstein Stiftung Berlin Zeitraum: 05/2012 - 12/2015 Projektleitung: Prof. Dr. rer. nat. Janina Kneipp
ACS Nano · DOI
The discovery of the enhancement of Raman scattering by molecules adsorbed on nanostructured metal surfaces is a landmark in the history of spectroscopic and analytical techniques. Significant experimental and theoretical effort has been directed toward understanding the surface-enhanced Raman scattering (SERS) effect and demonstrating its potential in various types of ultrasensitive sensing applications in a wide variety of fields. In the 45 years since its discovery, SERS has blossomed into a rich area of research and technology, but additional efforts are still needed before it can be routinely used analytically and in commercial products. In this Review, prominent authors from around the world joined together to summarize the state of the art in understanding and using SERS and to predict what can be expected in the near future in terms of research, applications, and technological development. This Review is dedicated to SERS pioneer and our coauthor, the late Prof. Richard Van Duyne, whom we lost during the preparation of this article.
Chemical Society Reviews · DOI
Surface enhanced Raman scattering (SERS) at extremely high enhancement level turns the weak inelastic scattering effect of photons on vibrational quantum states into a structurally sensitive single-molecule and nanoscale probe. The effect opens up exciting opportunities for applications of vibrational spectroscopy in biology. The concept of SERS can be extended to two-photon excitation by exploiting surface enhanced hyper-Raman scattering (SEHRS). This critical review introduces the physics behind single-molecule SERS and discusses the capabilities of the effect in bioanalytics (100 references).
Accounts of Chemical Research · DOI
This Account discusses surface-enhanced Raman scattering at extremely high enhancement levels that can occur for molecules attached to silver and gold nanoclusters. Strongly enhanced and highly confined local optical fields enable surface-enhanced Stokes and anti-Stokes Raman spectroscopy of single molecules even under nonresonant excitation conditions as well as extremely large effective cross sections in two-photon excited Raman spectroscopy. The ability for very sensitive and spatially confined molecular structural probing makes gold and silver nanoclusters very promising tools for studies of small structures in biological materials, such as cellular compartments.