Prof. Dr. phil. Stephan G. Schmid
Profil
Forschungsthemen21
12. International Conference on the History and Archaeology of Jordan (ICHAJ) (Veranstaltung: 05.-11.05.2013, Berlin)
Quelle ↗Förderer: DFG sonstige Programme Zeitraum: 04/2013 - 06/2013 Projektleitung: Prof. Dr. phil. Stephan G. Schmid
Antike römische Bauornamentik in Jordanien (II)
Quelle ↗Zeitraum: 07/2008 - 09/2008 Projektleitung: Prof. Dr. phil. Stephan G. Schmid
Antike römische Bauornamentik in Jordanien (IV)
Quelle ↗Förderer: DFG sonstige Programme Zeitraum: 06/2011 - 08/2011 Projektleitung: Prof. Dr. phil. Stephan G. Schmid
Archive der Vergangenheit. Wissenstransfers zwischen Archäologie, Philosophie und Künsten
Quelle ↗Förderer: Volkswagen Stiftung Zeitraum: 11/2010 - 12/2012 Projektleitung: Prof. Dr. phil. Stephan G. Schmid
Babunja und sein Umland. Die Erkundung einer antiken Kleinsiedlung an der südlichen Ostadriaküste
Quelle ↗Förderer: Fritz Thyssen Stiftung Zeitraum: 07/2016 - 05/2018 Projektleitung: Prof. Dr. phil. Stephan G. Schmid
Charakerisierung und Konservierung von Malereien an Wänden und Skulpturen in Petra
Quelle ↗Förderer: DFG Sachbeihilfe Zeitraum: 07/2016 - 08/2020 Projektleitung: Prof. Dr. phil. Stephan G. Schmid
CL Topoi: Monumentalarchitektur in Petra (A-I-16)
Quelle ↗Förderer: DFG Exzellenzinitiative Cluster Zeitraum: 04/2009 - 10/2012 Projektleitung: Prof. Dr. phil. Stephan G. Schmid
Cluster Topoi II: Eisen als Rohmaterial - Abbau und Verhüttung A-5-4
Quelle ↗Förderer: DFG Exzellenzinitiative Cluster Zeitraum: 11/2012 - 10/2017 Projektleitung: Prof. Dr. phil. Stephan G. Schmid
Cluster Topoi II: Stadtplanung und -entwicklung in Jordanien - C-6-2
Quelle ↗Förderer: DFG Exzellenzinitiative Cluster Zeitraum: 11/2012 - 10/2017 Projektleitung: Prof. Dr. phil. Stephan G. Schmid
Das al-Ula- al-Wajh Survey Project (UWSP)
Quelle ↗Förderer: DFG sonstige Programme Zeitraum: 03/2016 - 04/2016 Projektleitung: Prof. Dr. phil. Stephan G. Schmid
Das Ostia Forum Project OFP: Geophysikalische Surveys, Ausgrabung und digitale (2-D/3-D) Dokumentation der Platzanlagen und Bauten des Stadtzentrums von Ostia antica sowie ihrer Ausstattung vom 1. - 6. Jh. n. Chr.
Quelle ↗Förderer: Stiftung Humboldt-Universität Zeitraum: 08/2015 - 03/2026 Projektleitung: Prof. Dr. phil. Stephan G. Schmid, Dr. Axel Gering
„Der dorische Tempel in Shtyllasbei Apollonia (Albanien). Bauforschung – archäologische Neubewertung– Sicherung – Visualisierung“
Quelle ↗Förderer: DFG Sachbeihilfe Zeitraum: 08/2023 - 12/2025 Projektleitung: Prof. Dr. phil. Stephan G. Schmid
Der dorische Tempel in Shtyllas bei Apollonia (Albanien). Restaurierung - Visualisierung - Bauforschung - archäologische Neubewertung
Quelle ↗Förderer: Andere internationale Stiftungen Zeitraum: 09/2021 - 08/2026 Projektleitung: Prof. Dr. phil. Stephan G. Schmid
Der römische Limes in der europäischen Kulturlandschaft
Quelle ↗Förderer: DAAD Zeitraum: 09/2013 - 08/2014 Projektleitung: Prof. Dr. phil. Stephan G. Schmid
Die Entstehung eines arabischen Königreichs im hellenisierten Orient: Die Entwicklung von Petra, die Gestaltung des Umlandes und die Kontrolle der Ressourcen - Early Petra
Quelle ↗Förderer: DFG Sachbeihilfe Zeitraum: 01/2009 - 12/2011 Projektleitung: Prof. Dr. phil. Stephan G. Schmid
Die Entwicklung des Stadtzentrums von Petra (Jordanien) von hellenistischer bis in byzantinische Zeit
Quelle ↗Förderer: DFG Sachbeihilfe Zeitraum: 01/2022 - 11/2025 Projektleitung: Prof. Dr. phil. Stephan G. Schmid
Humboldts studentische Konferenz der Altertumswissenschaften, mit dem Thema EXPORTSCHLAGER Kultureller Austausch, wirtschaftliche Beziehungen und transnationale Entwicklungen in der antiken Welt (Veranstaltung: 23.09.-26.09.09, Berlin)
Quelle ↗Zeitraum: 06/2009 - 07/2011 Projektleitung: Prof. Dr. phil. Stephan G. Schmid
Kition-Idalion-Tamassos. Aus drei mach eins: Räumliche und kulturelle Dynamiken politischer Transformationen im eisenzeitlichen Zypern (6. bis 4. Jh. v.Chr.)
Quelle ↗Förderer: DFG Sachbeihilfe Internationale Kooperation Zeitraum: 02/2026 - 01/2029 Projektleitung: Prof. Dr. phil. Stephan G. Schmid
Kition-Idalion-Tamassos: Städte und Territorien in kyprischen Köngtümern im 1. Jahrtausend v.Chr.
Quelle ↗Förderer: DFG Sachbeihilfe Zeitraum: 04/2022 - 02/2026 Projektleitung: Prof. Dr. phil. Stephan G. Schmid, Dr. Matthias Recke, PD Dr. Sabine Fourrier
Siedlungsstrategien in marginalen Lebensräumen - Petra Cluster Topoi II: Siedlungsstrategien in marginalen Lebensräumen - Petra-A-1-2
Quelle ↗Förderer: DFG Exzellenzinitiative Cluster Zeitraum: 11/2012 - 10/2017 Projektleitung: Prof. Dr. phil. Stephan G. Schmid
Stipendium für Forschungsaufenthalt Dr. Nassar
Quelle ↗Förderer: DAAD Zeitraum: 06/2010 - 08/2010 Projektleitung: Prof. Dr. phil. Stephan G. Schmid
Mögliche Industrie-Partner10
Stand: 26.4.2026, 19:48:44 (Top-K=20, Min-Cosine=0.4)
- 74 Treffer59.8%
- Realizing Leibniz's Dream: Child Languages as a Mirror of the Mind (LeibnizDream)P59.8%
- Realizing Leibniz's Dream: Child Languages as a Mirror of the Mind (LeibnizDream)
- 43 Treffer59.3%
- Unterstützung einer inklusiven Anleitung für den Englischunterricht als Fremdsprache für gehörlose und schwerhörige SchülerP59.3%
- Unterstützung einer inklusiven Anleitung für den Englischunterricht als Fremdsprache für gehörlose und schwerhörige Schüler
- 41 Treffer59.3%
- Unterstützung einer inklusiven Anleitung für den Englischunterricht als Fremdsprache für gehörlose und schwerhörige SchülerP59.3%
- Unterstützung einer inklusiven Anleitung für den Englischunterricht als Fremdsprache für gehörlose und schwerhörige Schüler
- 47 Treffer59.3%
- Unterstützung einer inklusiven Anleitung für den Englischunterricht als Fremdsprache für gehörlose und schwerhörige SchülerP59.3%
- Unterstützung einer inklusiven Anleitung für den Englischunterricht als Fremdsprache für gehörlose und schwerhörige Schüler
Ecole Pouchet
PT45 Treffer59.3%- Unterstützung einer inklusiven Anleitung für den Englischunterricht als Fremdsprache für gehörlose und schwerhörige SchülerP59.3%
- Unterstützung einer inklusiven Anleitung für den Englischunterricht als Fremdsprache für gehörlose und schwerhörige Schüler
- 43 Treffer59.3%
- Unterstützung einer inklusiven Anleitung für den Englischunterricht als Fremdsprache für gehörlose und schwerhörige SchülerP59.3%
- Unterstützung einer inklusiven Anleitung für den Englischunterricht als Fremdsprache für gehörlose und schwerhörige Schüler
- 46 Treffer58.3%
- EU: Observatory for Political Texts in European Democracies: A European Research Infrastructure (OPTED)P58.3%
- EU: Observatory for Political Texts in European Democracies: A European Research Infrastructure (OPTED)
- 62 Treffer56.0%
- EU: Scattering Amplitudes: From Geometry to EXperiment (SAGEX)P56.0%
- EU: Scattering Amplitudes: From Geometry to EXperiment (SAGEX)
- 5 Treffer54.9%
- Sortenstrategien bei landwirtschaftlichen Nutzpflanzen zur Anpassung an den KlimawandelP54.9%
- Sortenstrategien bei landwirtschaftlichen Nutzpflanzen zur Anpassung an den Klimawandel
Landesamt für Verbraucherschutz, Landwirtschaft und Flurneuordnung Brandenburg
P5 Treffer54.9%- Sortenstrategien bei landwirtschaftlichen Nutzpflanzen zur Anpassung an den KlimawandelP54.9%
- Sortenstrategien bei landwirtschaftlichen Nutzpflanzen zur Anpassung an den Klimawandel
Publikationen25
Top 25 nach Zitationen — Quelle: OpenAlex (BAAI/bge-m3 embedded für Matching).
Nature Medicine · 359 Zitationen · DOI
Journal of Clinical Oncology · 253 Zitationen · DOI
The therapeutic index of hyperfractionated radiotherapy is improved by concomitant cisplatin.
Head & Neck · 179 Zitationen · DOI
PET with FDG turned out to have a poor sensitivity and specificity in revealing occult metastasis and has no role for the evaluation of otherwise clinically N0 necks. The failure to detect micrometastasis by PET is due to the technical limitations of resolution (4-5 mm). SLN biopsy, with END in cases of positive SLN, provides a highly accurate staging of N0 necks in oral and oropharyngeal carcinoma. Patients with negative SLN could be spared the risks and the morbidity of END.
Otolaryngology · 136 Zitationen · DOI
SLN evaluation in N0 neck in squamous cell carcinoma of the head and neck is accurately feasible and seems to adequately predict the presence of occult metastasis.
The Laryngoscope · 135 Zitationen · DOI
Whole-body PET is able to assess lymph node involvement, distant metastases, and second primaries in a single study. Even after a routine clinical staging, positron emission tomography leads to a change of treatment in approximately 8% of patients.
Archives of Otolaryngology - Head and Neck Surgery · 133 Zitationen · DOI
Whole-body PET scanning approximately 6 weeks after completion of a combined treatment regimen with radiation and chemotherapy can reliably identify locoregional residual cancer and distant metastases or secondary tumors in patients with advanced-stage HNSCC and has a direct influence on management decisions.
Salvage Surgery After Failure of Nonsurgical Therapy for Carcinoma of the Larynx and Hypopharynx
2000Archives of Otolaryngology - Head and Neck Surgery · 129 Zitationen · DOI
Salvage surgery in laryngeal cancer achieves good results, especially for small recurrences. Because of tumor progression, larynx preservation is seldom possible at the time of salvage. Salvage surgery in hypopharyngeal cancer shows poor survival regardless of tumor stage and despite radical surgical procedures, and can be recommended only for carefully selected patients. Arch Otolaryngol Head Neck Surg. 2000;126:1473-1477
The Laryngoscope · 111 Zitationen · DOI
Gustatory sweating is a well-known sequela after parotid surgery. In a retrospective and prospective study of patients undergoing parotid surgery, the onset, time course, extent, and treatment modalities of Frey's syndrome were analyzed. Twenty-two percent of the patients evaluated by questionnaires and 43% of the patients followed prospectively within 1 year were found to be symptomatic. Although the Minor starch-iodine test was positive in 38% of patients at 3 months, none of these patients experienced symptoms. Up to 12 months after surgery the rate of patients who tested positive increased to 96% and the total area of sweating expanded to a mean value of 18 cm2. Whereas most of the patients are not markedly disturbed, few patients (5% to 10%) suffer from severe gustatory sweating. These patients present a therapeutic challenge.
The Laryngoscope · 100 Zitationen · DOI
Quality of life after curative treatment of oropharyngeal carcinoma is generally good. Differences regarding quality of life between the different treatment modalities manifest themselves in the head and neck specific EORTC QLQ-H&N35 module, not in the global core questionnaire EORTC QLQ-C30.
Annals of Otology Rhinology & Laryngology · 100 Zitationen · DOI
A method is described that allows, for the first time, intraoperative vibration modes assessment of the acoustically stimulated stapes by means of scanning laser Doppler interferometry (LDI). The study was designed to answer the following questions: 1) Is LDI practical for taking measurements during surgery? 2) Are the results comparable to the findings in temporal bone preparations? and 3) Do the vibration characteristics of the stapes change after the posterior incudal ligament is detached from the incus? Seven patients with profound bilateral hearing loss who were undergoing cochlear implantation were included in the study. The measurement system was easily applicable for intraoperative measurements and allowed contact-free analysis with very high accuracy. No major differences in the results from the live human subjects and temporal bone preparations were observed. The stapes movement was predominantly pistonlike at the lower frequencies and became complex at higher frequencies. Sacrificing the posterior incudal ligament had no statistically significant effect on stapes vibration.
The Laryngoscope · 92 Zitationen · DOI
Occult metastasis can be subdivided histopathologically in isolated tumor cells, micrometastasis, and macrometastasis. We present the first study describing a great variety of these subtypes in sentinel lymph nodes from head and neck squamous cell carcinoma. Because the independent prognostic factor and clinical relevance of these subtypes is still unclear, we emphasize the importance of reporting these findings uniformly and according to well-established criteria.
Anesthesiology · 80 Zitationen · DOI
(Spahn) Instructor in Anesthesiology, Institute of Anesthesiology.(S. Schmid) Consultant, Department of Otorhinolaryngeology, Head and Neck Surgery.(Carrel) Instructor in Cardiac Surgery, Department of Cardiac Surgery.(Pasch) Professor and Director, Institute of Anesthesiology.(E. Schmid) Professor and Head, Division of Cardiovascular Anesthesiology, Institute of Anesthesiology.Received from the University Hospital, Zurich, Switzerland. Submitted for publication May 31, 1994. Accepted for publication September 16, 1994.Address reprint requests to Dr. Spahn: Institute of Anesthesiology, University Hospital, Ramistrasse 100, CH-8091 Zurich, Switzerland.Key words: Complication: hypopharynx perforation. Monitoring, transesophageal echocardiography.TRANSESOPHAGEAL echocardiography (TEE) generally is considered a low-risk procedure. [1,2] Major complications occur in approximately 0.2%; mortality is reported as 1 in 3,827 and 1 in 10,218 examinations, respectively. [1,2] These fatal complications were due to unspecified respiratory problems [2] and massive bleeding from a malignant lung tumor penetrating into the esophagus. [1] To the best of our knowledge, perforation along the orogastric pathway (hypopharynx esophagus, stomach) by TEE probe has not been described in the literature so far. We report a case of hypopharynx perforation by TEE probe with special emphasis on treatment and future prevention.A 75-yr-old woman with unstable angina was scheduled for emergency coronary artery bypass graft surgery. Cardiac catheterization revealed a 95% stenosis of the left main coronary artery and a 95% stenosis of the right coronary artery. A triple coronary artery bypass graft was planned.After monitoring radial arterial pressure, five-lead echocardiogram, and peripheral oxygen saturation by pulse oximetry, anesthesia was induced with flunitrazepam (11 micro gram/kg), fentanyl (5.5 micro gram/kg), and pancuronium (0.15 mg/kg). Endotracheal and gastric tubes were inserted without difficulties. Mean arterial pressure decreased, a significant ST-segment depression occurred in echocardiogram lead V5, and repetitive doses of phenylephrine (1 micro gram/kg each) were given. For further monitoring, a triple-lumen central venous catheter and a pulmonary artery catheter were inserted. The operation was begun and, because of still unstable hemodynamics, cardiopulmonary bypass was instituted immediately after sternotomy and cannulation of the aorta and the right atrium. Meanwhile, a second surgical team prepared the saphenous vein. On both legs, only two short segments of suitable saphenous veins were found. Because of the small caliber, the internal mammary arteries also were considered unsuitable bypass vessels. Thus, only the right coronary artery and the left anterior descending coronary artery could be grafted. Therefore, we decided to use TEE to monitor global cardiac function and, in particular, regional wall motion in the area of myocardium supplied by the left circumflex coronary artery. Inserting the TEE probe proved difficult: Elevating the mandible did not permit insertion of the probe into the esophagus, and the laryngoscope could not be used, because at our institution, the head of a patient undergoing cardiac surgery is placed under a cage-like construction that leaves only an approximately 2.2–4.4-cm space around the head in the oral area. After several attempts to advance the TEE probe gently, we suddenly were able to advance the probe; however, instead of having advanced the TEE probe into the esophagus, the TEE probe was protruding into the operating field from the upper mediastinum (Figure 1). The TEE probe was withdrawn, and a drain was advanced from the operating field into the perforation channel. This drain was exteriorized in the right pectoral area beside the incision of the sternotomy. Antibiotic therapy with vancomycin (initial dose 22.2 mg/kg) and imipenem (initial dose 9.2 mg/kg) was begun. The patient was separated from the cardiopulmonary bypass without electrocardiographic evidence of myocardial ischemia. The remainder of the operation was uneventful, and the sternum was closed in the normal manner.An otorhinolaryngologist was consulted to localize the exact site of perforation by rigid hypopharyngoscopy and to decide whether a local repair would be necessary. A highly stenotic entrance of the esophagus (diameter 3 mm) was found, which was caused by a massive hypertrophy of the cricopharyngeal muscle. Due to this stenosis, the hypopharynx was enlarged, but a classic Zenker's diverticulum could not be found. The perforation was localized on the left side of the hypopharynx 2.2 cm proximal to the cricopharyngeal muscle (Figure 2). The otorhinolaryngologist decided to surgically close the defect, and the patient was brought back to the operating room.Approximately 4 h after the perforation, the esophagus and the hypopharynx were exposed via a lateral cervicotomy on the cricoid level, and a myotomy of the cricoid muscle was performed. The perforation was sutured by an inverting method. To avoid a connection between the cervicotomy and the sternotomy, the previously placed drainage, which was advanced into the perforation channel, was shortened, and the cervicotomy was drained by an additional drainage, exteriorized at the neck. Postoperatively, the rigid hypopharyngoscopy was repeated and revealed an open passage to the esophagus and a closed perforation site.The patient was retransferred to the cardiosurgical intensive care unit in stable condition. Antibiotic therapy was continued with vancomycin, dosed according to plasma concentrations (before administration 3–10 mg/l, after administration 40–50 mg/l), and imipenem (9.2 mg/kg four times daily). The evening of the operations, the husband of the patient was informed. He also was interviewed on the swallowing habits of his wife. We learned that the patient had significant swallowing problems during the last 20 yr. so significant that her diet was almost totally fluid nutrients.The trachea was extubated the first postoperative day, and the patient was informed about the events of the previous day. She confirmed the significant swallowing problems during the last 20 yr. Intravenous antibiotic therapy was continued, the drainages were shortened by 1.1 cm daily, the gastric tube was left in situ, and the patient was not allowed to eat or drink (NPO). Hence, total parenteral nutrition was begun. Under this regimen, the patient remained essentially afebrile despite a considerable elevation of the leukocyte count (11,000 *symbol* mm sup -3) and C-reactive protein (200 mg/dl). On postoperative day 4, the patient was transferred to the regular cardiosurgical ward. Total parenteral nutrition, antibiotics, and NPO were continued.On postoperative day 11, a radiologic contrast agent swallow examination was performed. During this examination, the patient aspirated some contrast agent and coughed heavily. On postoperative day 12, a significant subcutaneous emphysema was detected. A computed tomography scan of the neck and upper thorax was performed to determine the extent of the emphysema. The computed tomography scan revealed that the emphysema was restricted to the neck; no penetration into the mediastinum was detected.The NPO regimen with unchanged antibiotic therapy was continued, pending spontaneous closure of the air leakage. Three days after the cervical emphysema had disappeared, a second radiologic contrast agent swallow study was performed (postoperative day 19). No fistula could be found, and the patient was allowed to start eating small portions of soft food under the assistance of a specially trained swallow therapist. Antibiotic therapy was discontinued, and infectious parameters remained low. On postoperative day 21, the patient aspirated considerable amounts of food into the trachea, and significant bilateral aspiration pneumonitis developed. The aspiration pneumonitis was treated with intense pulmonary physiotherapy and intravenous antibiotics (vancomycin and imipenem). Infectious parameters were continuously decreasing, and the antibiotic therapy was stopped on postoperative day 31. The patient was discharged from the hospital on postoperative day 49. Six months after the operation, no signs of late infections have occurred.Perforations along the orogastric pathway during fiberoptic gastroscopy occur with a rate of 1 in 3,020 to 1 in 12,644. [3–5] Twenty percent of these perforations occur in the hypopharynx, 40% in the esophagus, 5% in the stomach, and 35% in the duodenum. [4] Therefore, esophageal stricture, tumor, varices, diverticulae, esophageal interruption, and recent suture lines are considered absolute contraindications for the insertion of a TEE probe. [6] Significant swallowing problems can be regarded as indirect evidence for narrowing of the orogastric pathway and thus may be regarded as an additional, relative contraindication to insertion of a TEE probe. Therefore, it is suggested that patients in whom TEE monitoring is planned be questioned as to swallowing difficulties, even in emergency situations.The treatment of a patient after a perforation with a TEE probe includes (1) exact localization of the site of perforation, (2) probable surgical intervention, (3) immediate and aggressive antibiotic therapy, (4) NPO regimen with total parenteral nutrition and gastric drainage via nasogastric tube, and (5) radiologic testing for a fistula originating from the site of perforation before reinstituting oral nutrition. Early surgical repair may improve prognosis: In a large survey of more than 250,000 fiberoptic gastroscopies, a 10% mortality was observed in surgically treated perforations as compared to 37% in medically treated perforations, [4] and mortality decreased from 56% to 0% when intubation-related esophageal perforations were treated by early (less than 12 h) surgical intervention. [7].Surgical intervention includes the local repair at the site of perforation and, most importantly, the separation of the perforation site at the neck and the primary site of operation, the mediastinum. This separation of operation fields is of prime importance, because it increases the chances that a potential infectious process may be limited to the neck rather than expanding into the mediastinum.The NPO regimen until radiologic confirmation of consolidation of the local repair and absence of a fistula originating from the site of perforation is important, because penetration of food particles into a fistula could induce major infectious complications.Interviewing patients on swallowing difficulties can alert the anesthesiologist to a yet unknown narrowing of the orogastric pathway and potentially prevent future perforations by TEE probes. Also, inserting the TEE probe under direct vision using the laryngoscope is advisable should resistance be encountered at the initial attempt of blind insertion of the TEE probe.
Skull base · 77 Zitationen · DOI
In 1982, Fisch described his results for the surgical treatment of 74 paragangliomas of the temporal bone, 5 years after his description of the infratemporal fossa approaches (types A and B). This study reviews the subsequent experience of the Department of Otolaryngology-Head and Neck Surgery of the University of Zürich with more than 136 surgically treated cases of paraganglioma of the temporal bone and discusses our current therapy 20 years after the initial description. One hundred nineteen (90%) of the patients had advanced tumors (Fisch class C or C+D), and 81 (68%) had intracranial extension. Total tumor excision was possible in 109 (82%) patients. Subtotal excision was performed in 22 (17%) patients, 21 of whom had intradural tumor invasion. In these cases, the resection was limited not by actual tumor size but by the degree of intracranial intradural tumor extension. Partial tumor excision was undertaken in only 1 patient with a C4De2Di2 tumor. The success rate in preservation of function of the lower cranial nerves was encouraging. Of the 69 patients whose facial nerve status was followed post-operatively, 81% maintained Fisch grade 76 to 100% (House-Brackman grades I and II). Analysis of follow-up data ranging from 2 to 11 years demonstrated 98% disease-free survival when total tumor extirpation was possible. In the patients who underwent subtotal or partial surgical resection there has been no subsequent tumor growth detected by either clinical or neuroradiological evaluation. We have confirmed after more than 20 years of experience that the infratemporal fossa approaches are a safe, highly effective means of surgical management of paragangliomas of the temporal bone, allowing eradication or arrest of disease with minimal morbidity. Limited intradural surgical resection in cases of very extensive tumors can greatly benefit patients for whom complete excision is not an option.
International Journal of Cancer · 69 Zitationen · DOI
Proteins of the lysyl oxidase (LOX) family are important modulators of the extracellular matrix. However, they have an important role in the tumour development as well as in tumour progression. To evaluate the diagnostic and prognostic value of the LOX protein in oral and oropharyngeal squamous cell carcinoma (OSCC) we performed QRT-PCR and immunohistochemical analysis on two tissue microarrays (622 tissue samples in total). Significantly higher LOX expression was detected in high grade dysplastic oral mucosa as well as in OSCC when compared to normal oral mucosa (P < 0.001). High LOX expression was correlated with clinical TNM stage (P = 0.020), lymph node metastases for the entire cohort (P < 0.001), as well as in the subgroup of small primary tumours (T1/T2, P < 0.001). Moreover, high LOX expression was correlated with poor overall survival (P = 0.004) and disease specific survival (P = 0.037). In a multivariate analysis, high LOX expression was an independent prognostic factor, predicting unfavourable overall survival. In summary, LOX expression is an independent prognostic biomarker and a predictor of lymph node metastasis in OSCC. Moreover, LOX overexpression may be an early phenomenon in the pathogenesis of OSCC and thus an attractive novel target for chemopreventive and therapeutic strategies.
Otology & Neurotology · 68 Zitationen · DOI
Tight fixation, as provided by Nitinol prostheses leads to improved functional results because of better sound transmission properties at the incus-prosthesis interface. The improvement in ABG closure is in the range of 3 dB pure-tone average and more pronounced at higher frequencies. Nitinol prostheses provide an effective treatment option in otosclerosis surgery.
Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · 68 Zitationen · DOI
The Laryngoscope · 66 Zitationen · DOI
Abstract To directly compare percutaneous dilational tracheostomy (PDT) with conventional surgical tracheostomy, a prospective study was performed in 83 patients requiring tracheostomy for prolonged mechanical ventilation in the intensive care unit or after surgery for a large tumor in the upper respirodigestive tract. Median follow‐up was 355 days after PDT and 338 days after conventional tracheostomy. The overall morbidity rate was significantly lower with PDT than with conventional tracheostomy (6.4% vs 36.1%; P < 0.001). Compared with conventional tracheostomy, PDT was also associated with a significantly lower incidence of postoperative bleeding (2.1% vs 13.9%; P < 0.05) and postoperative wound infection (0% vs 22.2%; P < 0.001). There were no clinical signs of laryngotracheal stenosis in either group. In conclusion, PDT is a simple, fast, safe bedside procedure that is associated with significantly lower morbidity than standard surgical tracheostomy.
The Laryngoscope · 65 Zitationen · DOI
Early disease can be treated with high long-term QoL by surgery alone. Primary surgery with postoperative RT in selected patients with limited primary tumors and advanced neck disease renders excellent QoL. Our results suggest that IMRT is superior to former radiation techniques with regard to QoL, and should be considered as standard of care in patients undergoing RT for OPSCC. Patients with p16 positive tumors appear to show not only a better outcome but also report on a better QoL.
Head & Neck · 65 Zitationen · DOI
Selection of the treatment modality according to patient's preference results in a comparable control of disease for T1 tumors. The initial local control for T2 tumors is significantly better after surgery. In both stages laser surgery warrants a better larynx preservation rate.
European Archives of Oto-Rhino-Laryngology · 65 Zitationen · DOI
Annals of Otology Rhinology & Laryngology · 62 Zitationen · DOI
Percutaneous tracheostomy (PT) is an ancient procedure that has recently attracted increasing interest. While there are numerous publications in the literature, there remains confusion due to the large variety of techniques and instruments with which it has been performed and the wide disparity in clinical outcome. This study evaluates the international literature on over 1,500 cases, classifies the techniques that have been used, analyzes the safety of each method, and reports a prospective outcome and cost analysis of 130 cases undergoing what we determined to be the safest method. We found that PT performed with the correct instruments and technique under bronchoscopic surveillance has a lower incidence of complications than open tracheostomy (OT). Cost estimation demonstrated that PT may be significantly more expensive than bedside OT. While we recommend PT as a relatively safe and expedient method of tracheostomy for selected intubated patients in an intensive care unit, it does not offer an advantage for patients who must be taken to the operating room, and should not deprive house officers of necessary experience in OT in this setting.
Journal of Pragmatics · 61 Zitationen · DOI
Surgical treatment of early oral carcinoma—Results of a prospective controlled multicenter study
2001Head & Neck · 57 Zitationen · DOI
Early (pT1-2, pN0-1) squamous cell carcinoma of the oral cavity is adequately treated by surgery alone, provided the resection margins are tumor free. On the basis of the presented data, we would also advocate routine selective neck dissection.
A Prospective Randomized Double‐Blind Trial of Fibrin Glue for Pain and Bleeding After Tonsillectomy
1999The Laryngoscope · 57 Zitationen · DOI
The patient-based pain evaluation data should aid the physician in preoperative outcome counselling and targeted prescription of pain medication. However, contrary to previous indications, the authors cannot substantiate a significant beneficial effect of fibrin glue in postoperative pain control. Furthermore, we did not find its action as a hemostatic agent clinically applicable in this setting, and thus find no indication for the routine use of fibrin glue in tonsillectomy.
Otolaryngology · 56 Zitationen · DOI
Patients with squamous cell carcinoma of the aerodigestive tract routinely undergo panendoscopy to detect possible synchronous second primary tumors. The aim of our study was to assess the incidence of synchronous and metachronous second primary tumors and to refine the role of panendoscopy. The charts of 358 patients evaluated by means of panendoscopy during work‐up of a first primary squamous cell carcinoma of the upper aerodigestive tract were reviewed. The incidence of a second primary tumor was 16.2%, with 6.4% being synchronous and 9.8% being metachronous. In only 3.1% of all patients, a synchronous tumor was clinically silent and only revealed by means of the panendoscopy. The synchronous tumors were mainly in the oral cavity, pharynx, or larynx (61%), whereas the metachronous tumors were most likely in the lung (57%). Despite the low incidence of synchronous second primary tumors, we still recommend panendoscopy for assessment of the primary tumor and as a training field for residents.
Kooperationen5
Bestätigte Forscher↔Partner-Paare aus HU-FIS — Gold-Standard-Positive für das Matching.
Die Entwicklung des Stadtzentrums von Petra (Jordanien) von hellenistischer bis in byzantinische Zeit
university
Kition-Idalion-Tamassos. Aus drei mach eins: Räumliche und kulturelle Dynamiken politischer Transformationen im eisenzeitlichen Zypern (6. bis 4. Jh. v.Chr.)
other
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Charakerisierung und Konservierung von Malereien an Wänden und Skulpturen in Petra
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Stammdaten
Identität, Organisation und Kontakt aus HU-FIS.
- Name
- Prof. Dr. phil. Stephan G. Schmid
- Titel
- Prof. Dr. phil.
- Fakultät
- Kultur-, Sozial- und Bildungswissenschaftliche Fakultät
- Institut
- Institut für Archäologie
- Arbeitsgruppe
- Klassische Archäologie
- Telefon
- +49 30 2093-98125
- HU-FIS-Profil
- Quelle ↗
- Zuletzt gescrapt
- 26.4.2026, 01:11:57