Prof. Dr. Hans Börner
Profil
Forschungsthemen14
Bio-Hybridpolymere
Quelle ↗Zeitraum: 01/2011 - 07/2013 Projektleitung: Prof. Dr. Hans Börner
Chimera for Industry (Henkel 1)
Quelle ↗409 · InformatikZeitraum: 12/2009 - 09/2010 Projektleitung: Prof. Dr. Hans Börner
DFG-Sachbeihilfe: Design, Synthese und Untersuchung Kollagen-inspirierter Templat-[Protein]3-Hybride: Von hochmolekular schaltbaren Strukturbildnern zur Prozessierung Kollagen-artiger Materialien für die Zellkultur
Quelle ↗Förderer: DFG Sachbeihilfe Zeitraum: 01/2014 - 12/2017 Projektleitung: Prof. Dr. Hans Börner
DFG-Sachbeihilfe: Muschel-inspirierte Polymerisation: Die enzymfreie Route der Tyrosinase-aktivierten Polymerisation
Quelle ↗Förderer: DFG Sachbeihilfe Zeitraum: 03/2020 - 02/2024 Projektleitung: Prof. Dr. Hans Börner
DFG-Sachbeihilfe: Polymerisieren wie die Muschel: Über Tyrosinase-aktivierte Polymerisation zu multifunktionalen Polymeren
Quelle ↗Förderer: DFG Sachbeihilfe Zeitraum: 01/2014 - 12/2017 Projektleitung: Prof. Dr. Hans Börner
DFG-Sachbeihilfe: Templatgesteuerte Synthese von komplexen Monomer-Sequenzen in Kettenpolymerisationen
Quelle ↗Förderer: DFG Sachbeihilfe Zeitraum: 02/2015 - 12/2018 Projektleitung: Prof. Dr. Hans Börner
Digging Deep into the Sequence Space of Electrochemical Debonding of Peptides to Impact Next Generation Polymer Adhesives (IDefix)
Quelle ↗Förderer: Horizon Europe: ERC Advanced Grant Zeitraum: 03/2026 - 02/2031 Projektleitung: Prof. Dr. Hans Börner
Ein biokombinatorischer Ansatz zu enzymatisch aktivierbaren Klebstoffen
Quelle ↗Förderer: DFG Sachbeihilfe Zeitraum: 03/2011 - 03/2015 Projektleitung: Prof. Dr. Hans Börner
ERC: SPECIFICALLY INTERACTING POLYMERS – From Selective Adhesion Toward Specific Recognition (SIP)
Quelle ↗Zeitraum: 01/2013 - 12/2017 Projektleitung: Prof. Dr. Hans Börner
EU: Monomer Sequence Control in Polymers: Toward Next-Generation Precision Materials (EURO-SEQUENCES)
Quelle ↗Zeitraum: 01/2015 - 12/2018 Projektleitung: Prof. Dr. Hans Börner
Frauenförderung
Quelle ↗Zeitraum: 02/2012 - 10/2014 Projektleitung: Prof. Dr. Hans Börner
Kolloid-getragene Synthese von Peptiden und Peptid-Polymer-Konjugaten
Quelle ↗Förderer: DFG Sachbeihilfe Zeitraum: 02/2010 - 01/2013 Projektleitung: Prof. Dr. Hans Börner
Neuartige Muschel-Haft-Proteine mit Kohäsionskontrolle zu verbesserten Muschelinspirierten Klebstoffen.
Quelle ↗Förderer: Alexander von Humboldt-Stiftung: Forschungskostenzuschuss Zeitraum: 04/2018 - 03/2020 Projektleitung: Prof. Dr. Hans Börner
Orthogonal Modification of Biopolymers With Variable Peptide Sequences via Ultra-Rapid Covalent Modification
Quelle ↗Förderer: DFG Sachbeihilfe Zeitraum: 01/2011 - 12/2013 Projektleitung: Prof. Dr. Hans Börner
Mögliche Industrie-Partner10
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- EU: Monomer Sequence Control in Polymers: Toward Next-Generation Precision Materials (EURO-SEQUENCES)
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- EU: Monomer Sequence Control in Polymers: Toward Next-Generation Precision Materials (EURO-SEQUENCES)
- 124 Treffer61.4%
- Interfaces in opto-electronic thin film multilayer devicesP61.4%
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- DYnamic control in hybrid plasmonic NAnopores: road to next generation multiplexed single MOlecule detectionP59.1%
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BASF SE
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- Zuwendung im Rahmen des Programms „exist – Existenzgründungen aus der Wissenschaft“ aus dem Bundeshaushalt, Einzelplan 09, Kapitel 02, Titel 68607, Haushaltsjahr 2026, sowie aus Mitteln des Europäischen Strukturfonds (hier Euro-päischer Sozialfonds Plus – ESF Plus) Förderperiode 2021-2027 – Kofinanzierung für das Vorhaben: „exist Women“
- 17 Treffer58.2%
- The Novel Materials Discovery Laboratory (NoMaD)P58.2%
- The Novel Materials Discovery Laboratory (NoMaD)
- The Novel Materials Discovery Laboratory (NoMaD)P58.2%
- EU: Context Sensitive Multisensory Object Recognition (HBP)T52.5%
- The Novel Materials Discovery Laboratory (NoMaD)
Publikationen25
Top 25 nach Zitationen — Quelle: OpenAlex (BAAI/bge-m3 embedded für Matching).
Nature · 596 Zitationen · DOI
Progress in Polymer Science · 532 Zitationen · DOI
Macromolecules · 397 Zitationen · DOI
Brush macromolecules having poly(n-butyl acrylate-block-styrene) and poly(styrene-block-n-butyl acrylate) side chains have been synthesized by the "grafting from" approach using atom transfer radical polymerization (ATRP). The molecular weights of the resulting polymers were characterized by gel permeation chromatography (GPC) using refractive index and multiangle light scattering detection. The block copolymer side chains were cleaved from the backbone and analyzed by GPC, confirming the synthesis of well-defined copolymer brushes. Visualization of individual molecules by atomic force microscopy (AFM) enabled analysis of the conformation and microstructure of the brush macromolecules on mica surface. The brushes with the pnBuA core were almost fully stretched, while the inverted structure with the pS core exhibited longitudinal contraction compared to the contour length of the main chain. In addition, the poly(n-butyl acrylate-block-styrene) brushes demonstrated a characteristic necklace morphology which was attributed to the interplay between the extension of the pnBuA core and microphase segregation of the pS tails.
Angewandte Chemie International Edition · 362 Zitationen · DOI
A wash and brush up: Thermoresponsive and biocompatible oligo(ethylene glycol)-based copolymers enable the control of cell adhesion on planar gold substrates. While at physiological temperature, the polymer brushes are collapsed and enable fibroblast adhesion and cultivation, at room temperature, the now hydrated oligo(ethylene glycol) segments become cell-repellent, thus allowing cell harvesting under mild conditions (see scheme).
Macromolecular Rapid Communications · 289 Zitationen · DOI
Abstract Summary: The bromine chain ends of well‐defined polystyrene ( $\overline M _{\rm n}$ = 2 700 g · mol −1 , $\overline M _{\rm w} /\overline M _{\rm n}$ = 1.11) prepared using ATRP were successfully transformed into various functional end groups ( ω ‐hydroxy, ω ‐carboxyl and ω ‐methyl‐vinyl) by a two‐step pathway: (1) substitution of the bromine terminal atom by an azide function and (2) 1,3‐dipolar cycloaddition of the terminal azide and functional alkynes (propargyl alcohol, propiolic acid and 2‐methyl‐1‐buten‐3‐yne). The “click” cycloaddition was catalyzed efficiently by the system copper bromide/4,4′‐di‐(5‐nonyl)‐2,2′‐bipyridine. In all cases, 1 H NMR spectra indicated quantitative transformation of the chain ends of polystyrene into the desired function. Preparation of well‐defined functional polymers possessing diverse chain‐end functionalities by the combination of atom transfer radical polymerization and click chemistry. image Preparation of well‐defined functional polymers possessing diverse chain‐end functionalities by the combination of atom transfer radical polymerization and click chemistry.
Macromolecules · 267 Zitationen · DOI
The bromine chain-ends of well-defined poly(oligo(ethylene glycol) acrylate) (POEGA) (Mn = 6850 g·mol-1, Mw/Mn = 1.21) prepared using ATRP were successfully transformed into various functional end groups (ω-hydroxy, ω-amino, and ω-Fmoc-amino acid) via a two step pathway: (1) substitution of the bromine terminal atom by an azide function, (2) 1,3-dipolar cycloaddition of the terminal azide and functional alkynes (propargyl alcohol, propargylamine, and N-α-(9-fluorenylmethyloxycarbonyl)-l-propargylglycine). The efficient “click” cycloaddition was confirmed in all cases by 1H NMR or SEC−UV analysis. Moreover, this two-step synthetic strategy was also studied for preparing polymer-b-oligopeptide bioconjugates. Well-defined POEGA-b-GGRGDG was obtained in high yields via the “click” ligation of the azido functional POEGA and the alkyne functional oligopeptide GGRGDG.
Physical review. D. Particles, fields, gravitation, and cosmology/Physical review. D. Particles and fields · 249 Zitationen · DOI
The lowest stationary quantum state of neutrons in the Earth's gravitational field is identified in the measurement of neutron transmission between a horizontal mirror on the bottom and an absorber/scatterer on top. Such an assembly is not transparent for neutrons if the absorber height is smaller than the ``height'' of the lowest quantum state.
Soft Matter · 221 Zitationen · DOI
The diversity and complexity of structures and functions in synthetic polymer systems can be increased through conjugation with biological segments or, in other words, through generation of "polymer-bioconjugates" or "macromolecular chimeras". The present contribution highlights major synthetic approaches toward sophisticated functional hybrid block copolymers and analyses of structure-function relationships.
The European Physical Journal C · 195 Zitationen · DOI
Progress in Polymer Science · 192 Zitationen · DOI
Synthesis of Molecular Brushes with Gradient in Grafting Density by Atom Transfer Polymerization
2002Macromolecules · 189 Zitationen · DOI
Macromolecular brushes with a gradient of side-chain spacing along the backbone have been synthesized by the "grafting from" approach using atom transfer radical polymerization. A macroinitiator was prepared in two steps, first by conducting a gradient copolymerization of MMA and HEMA-TMS followed by transformation of the resulting poly(MMA-grad-HEMA-TMS) to poly(MMA-grad-BPEM). The gradient composition of the macroinitiator was a forced gradient formed by continuous feeding of HEMA-TMS during MMA polymerization. The gradient structure was characterized by monitoring monomer conversion (GC) and molecular weight evolution (GPC) during copolymerization. AFM measurements demonstrated the characteristic anisotropy of the molecular structure by resolving individual brush molecules with a bulky head and a thin tail.
Angewandte Chemie International Edition · 186 Zitationen · DOI
A photoconjugation strategy based on light-triggered Diels–Alder addition of o-quinodimethanes is compatible with biomolecules and proceeds rapidly at ambient temperature without the need of a catalyst. Spatial control was confirmed by photopatterning of a small-molecule ATRP initiator, a polymer, and a peptide in a time-of-flight secondary-ion mass spectrometry investigation.
Advanced Materials · 162 Zitationen · DOI
Abstract The established technology platforms of solid‐phase‐supported oligopeptide and oligonucleotide synthesis can be expanded to access fully synthetic macromolecules, preserving both the monodisperse character and the defined monomer sequence. Precision polymers are sequentially assembled from a library of functional building blocks, enabling one to program interaction capabilities or generate functions by sequence‐specific positioning of functionalities. Examples are provided, showing that these monodisperse macromolecules can be conjugated to oligonucleotides, oligopeptides, or poly(ethylene glycol)s. The resulting model systems can contribute to the understanding of complex biomedical‐related processes. Due to the absence of chemical and molecular‐weight distributions in these multifunctional segments, exact correlation of the monomer sequence and (bio)properties is attainable. This is demonstrated by the design of carrier systems that exhibit fine‐tuned interactions with plasmid DNA, actively controlling important steps in DNA delivery and transfection, such as polyplex formation, DNA compression, and release of the cargo.
Nature · 156 Zitationen · DOI
Journal of the American Chemical Society · 152 Zitationen · DOI
A strong beta-sheet forming peptide was conjugated to PEO and utilized to guide the structure formation process toward well-defined, tape-like structures with millimeters in length, about 2 mum width, and approximately 50 nm height. The aggregation tendency of the peptide was temporarily suppressed for ease of synthesis by the integration of multiple switch-peptide defect segments into the peptide backbone. A subsequent rearrangement in the defects re-establishes the native peptide backbone and triggers the assembly by switching the aggregation properties on.
Biomacromolecules · 139 Zitationen · DOI
A novel synthesis route toward multifunctional, sequence-defined polyamides is described. A fully automated, solid-phase supported polymer synthesis was developed and utilized to obtain linear poly(amidoamine) segments (PAAs) that exhibit the absence of molecular weight and chemical distribution. This was achieved by an alternating assembly of diacids and diamines, using a forced step-growth mechanism, and driving each coupling step to completion. Within the monodisperse PAA segment, functionalities can be precisely positioned along the polymer chain allowing local control of the chain properties. The versatility of the approach was demonstrated by the conjugation of the monodisperse PAA segment toward an oligopeptide, leading to a single component block copolymer as verified by mass spectrometry. Moreover, two different poly(ethylene oxide)-PAA conjugates were synthesized utilizing the direct, solid-phase supported route. By varying the PAA repeat unit, the cationic nature of the PAA segment was adjusted, demonstrating the potential of the approach. The products were characterized by means of 1H NMR and matrix-assisted laser desorption mass spectrometry (MALDI-TOF-MS) methods, which confirmed the chemical structures conclusively.
Journal of Physics G Nuclear Physics · 131 Zitationen · DOI
The levels and gamma decay in168Er have been investigated following thermal neutron capture on enriched targets of 167Er2O3. Precision measurements of the gamma spectrum with curved-crystal spectrometers revealed over 700 transitions up to an energy of 2.5 MeV, with intensities spanning five orders of magnitude. A list of primary gamma transitions populating levels in 168Er up to an excitation energy of 3.1 MeV resulted from measurements with the pair spectrometer. Information on the gamma spectrum in the energy region 1400<E<2600 keV was obtained using a Ge(Li) spectrometer. The conversion electron spectrum up to 2.2 MeV electron energy was measured with a beta spectrometer, whence multipolarities of many of the transitions were derived. Average resonance capture measurements at neutron energies of 2 keV and 24 keV were made which ensured that the set of spin 2-5 levels below about 2.2 MeV was complete. From all these data, employing the Ritz combination principle, a level scheme was developed and the levels were arranged into a complete set of 20 low-K rotational bands. This is the most complete and extensive test of the limits of applicability of models for low-lying collective excitations.
Chemical Communications · 128 Zitationen · DOI
Template pre-organized oligopeptides were conjugated to poly(ethylene oxide) chains yielding peptide-polymer-building blocks that self assemble into fiber-like nanostructures having a maximum length in the range of a micrometer.
Advanced Materials · 127 Zitationen · DOI
A first representative of a novel class of bioinspired materials is introduced, a fully symmetric hybrid between an oligothiophene and a β-sheet peptide. The conjugate is synthesized via “click chemistry”, and employs a switch-peptide segment to gain control over the self-assembly motif of the peptide part. The self-organization properties of the hybrid are investigated.
Journal of the American Chemical Society · 127 Zitationen · DOI
Synthesis and peptide-guided self-assembly of an organo-soluble peptide-polymer conjugate, comprising a sequence-defined polypeptide and a poly(n-butyl acrylate), are described. The amino acid sequence of the peptide encodes a high tendency to adopt an antiparallel beta-sheet motif, and thus programs the formation of tapelike microstructures. Easy synthesis and controllable self-assembly is ensured by the incorporation of structure breaking switch defects into the peptide segment. This suppresses temporarily the aggregation tendency of the conjugate as shown by circular dichroism, infrared spectroscopy (FT-IR), and atomic force microscopy (AFM). A pH-controlled rearrangement in the switch segments restores the native peptide backbone, triggering the self-assembly process and leading to the formation of densely twisted tapelike microstructures as could be observed by AFM and transmission electron microscopy. The resulting helical superstructures, when deposited on a substrate, are 2.9 nm high, 10 nm wide, and up to 2.3 mum long. The helical pitch is about 37 nm, and the pitch angle is 48 degrees . The helical superstructures undergo defined entanglement to form superhelices, leading to the formation of soft, continuous organo-gels. A twisted two-dimensional core-shell tape is proposed as a structure model, in which the peptide segments form an antiparallel beta-sheet with a polymer shell.
Angewandte Chemie International Edition · 118 Zitationen · DOI
Making light work of ligation: A novel method utilizes light for oxime ligation chemistry. A quantitative, low-energy photodeprotection generates aldehyde, which subsequently reacts with aminooxy moieties. The spatial control allows patterning on surfaces with a fluoro marker and GRGSGR peptide, and can be imaged by time-of-flight secondary-ion mass spectrometry.
Macromolecules · 117 Zitationen · DOI
Straightforward solid-phase-supported synthesis routes were presented to obtain novel oligopeptide-based reversible addition fragmentation transfer (RAFT) agents. These approaches include the coupling of a functional RAFT agent to a resin-bound peptide and the functionality switch of an oligopeptide ATRP macroinitiator into an oligopeptide transfer agent. The solid-phase-supported methods allowed easy purification of the transfer agents, making difficult column purification steps unnecessary. Well-defined conjugates comprising sequence-defined peptides and synthetic polymers could be accessed by applying RAFT polymerization techniques in combination with the peptide macrotransfer agents. Polymerization reactions of n-butyl acrylate were performed in solution, yielding peptide−polymer conjugates with controllable molecular weight and low polydispersities of around 1.1. The peptide−polymer conjugates were characterized using 1H NMR spectroscopy and size exclusion chromatography (SEC), while the incorporation of the oligopeptide into the synthetic polymer and the preservation of the chirality were shown by circular dichroism (CD) spectroscopy.
Macromolecular Rapid Communications · 117 Zitationen · DOI
Abstract Summary: A novel two‐step polymerization strategy allowing the integration of sequence‐defined oligopeptides into synthetic polymers has been demonstrated by the successful synthesis of an oligopeptide‐ block ‐poly( n ‐butyl acrylate) copolymer. The approach utilizes a solid‐phase supported synthesis of an oligopeptide macroinitiator (SPPS) followed by solution‐phase atom transfer radical polymerization (ATRP) initiated by the oligopeptide macroinitiator. The resulting block copolymer exhibited a low $\overline M _{\rm w} /\overline M _{\rm n}$ (1.19) and a controllable $\overline M _{\rm n}$ . Poly( n ‐butyl acrylate)‐ block ‐oligopeptide. image Poly( n ‐butyl acrylate)‐ block ‐oligopeptide.
Macromolecules · 114 Zitationen · DOI
The synthesis of peptide−polymer conjugates comprising (d-alt-l)-cyclopeptides as aggregator domains and their self-assembly into tubelike structures is described. By coupling two well-defined poly(n-butyl acrylate) blocks to opposite sides of a preformed cyclic (d-alt-l)-α-octapeptide, a coil−ring−coil bioconjugate was accessed. The applied solution-phase coupling route allowed a multigram scale synthesis of the conjugate and assured both a controlled synthesis and ease of analysis. The controlled self-assembly of the conjugate leads to uniform tube structures. Atomic force microscopy (AFM) of these aggregates deposited on mica revealed a height of 1.4 ± 0.2 nm, a width of 5 nm, and roughly estimated lengths of up to 200−300 nm. A model is proposed, explaining the structure dimensions. This includes the formation of a tubular peptide core build via stacking of the cyclopeptides and a poly(n-butyl acrylate) shell wrapping around the peptide tube. The model is consistent with infrared spectroscopy and electron diffraction measurements, verifying that the peptide segment of the conjugate adopts a β-sheet structure, similar to unsubstituted (d-alt-l)-cyclopeptides. Hence, the stacks of peptide rings are stabilized along the fiber axis via inter-ring β-sheet H-bonding. The tube structures are capable to interact laterally, organizing further into weak networks as was evidenced by AFM and transmission electron microscopy.
Advanced Materials · 111 Zitationen · DOI
Surface-biofunctionalized synthetic polymer fibers composed of a fiber-forming host polymer and an oligopeptide conjugate are prepared by electrospinning. The conjugate consists of a polypeptide segment and a polymer block that is compatible with the host polymer. Because the more polarizable peptide segment migrates to the surface during electrospinning, peptide surface enrichment (see figure and inside cover) is achieved in a single step without further treatment.
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EU: Monomer Sequence Control in Polymers: Toward Next-Generation Precision Materials (EURO-SEQUENCES)
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Orthogonal Modification of Biopolymers With Variable Peptide Sequences via Ultra-Rapid Covalent Modification
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EU: Monomer Sequence Control in Polymers: Toward Next-Generation Precision Materials (EURO-SEQUENCES)
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EU: Monomer Sequence Control in Polymers: Toward Next-Generation Precision Materials (EURO-SEQUENCES)
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EU: Monomer Sequence Control in Polymers: Toward Next-Generation Precision Materials (EURO-SEQUENCES)
university
EU: Monomer Sequence Control in Polymers: Toward Next-Generation Precision Materials (EURO-SEQUENCES)
university
EU: Monomer Sequence Control in Polymers: Toward Next-Generation Precision Materials (EURO-SEQUENCES)
university
EU: Monomer Sequence Control in Polymers: Toward Next-Generation Precision Materials (EURO-SEQUENCES)
university
Stammdaten
Identität, Organisation und Kontakt aus HU-FIS.
- Name
- Prof. Dr. Hans Börner
- Titel
- Prof. Dr.
- Fakultät
- Mathematisch-Naturwissenschaftliche Fakultät
- Institut
- Institut für Chemie
- Arbeitsgruppe
- Organische Synthese funktionaler Systeme
- Telefon
- +49 30 2093-82852
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- 26.4.2026, 01:02:53