Dr. Lars Dietrich

Profil

Zusammenfassung

Dr. Lars Dietrich erforscht die Rolle von Signalmolekülen in bakteriellen Biofilmen, insbesondere wie Phenazine die Genexpression, den Stoffwechsel und die Gemeinschaftsstruktur von Pseudomonas aeruginosa steuern. Seine Expertise liegt in der Analyse von Bakterien-Ökosystemen und deren chemischen Kommunikationsmechanismen, was für die Entwicklung von Strategien gegen biofilmbasierte Infektionen relevant ist.

Skills

Name

Dr. Lars Dietrich

Titel

Dr.

Fakultät

Kultur-, Sozial- und Bildungswissenschaftliche Fakultät

Institut

Institut für Rehabilitationswissenschaften

Arbeitsgruppe

Pädagogik bei psychosozialen Beeinträchtigungen

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HU-FIS-Profil

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  Zeitraum: 10/2019 - 09/2020 Projektleitung: Dr. Lars Dietrich

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• The phenazine pyocyanin is a terminal signalling factor in the quorum sensing network of <i>Pseudomonas aeruginosa</i>

  2006

  Molecular Microbiology · 721 Zitationen · DOI

  Certain members of the fluorescent pseudomonads produce and secrete phenazines. These heterocyclic, redox-active compounds are toxic to competing organisms, and the cause of these antibiotic effects has been the focus of intense research efforts. It is largely unknown, however, how pseudomonads themselves respond to - and survive in the presence of - these compounds. Using Pseudomonas aeruginosa DNA microarrays and quantitative RT-PCR, we demonstrate that the phenazine pyocyanin elicits the upregulation of genes/operons that function in transport [such as the resistance-nodulation-cell division (RND) efflux pump MexGHI-OpmD] and possibly in redox control (such as PA2274, a putative flavin-dependant monooxygenase), and downregulates genes involved in ferric iron acquisition. Strikingly, mexGHI-opmD and PA2274 were previously shown to be regulated by the PA14 quorum sensing network that controls the production of virulence factors (including phenazines). Through mutational analysis, we show that pyocyanin is the physiological signal for the upregulation of these quorum sensing-controlled genes during stationary phase and that the response is mediated by the transcription factor SoxR. Our results implicate phenazines as signalling molecules in both P. aeruginosa PA14 and PAO1.

• Rethinking 'secondary' metabolism: physiological roles for phenazine antibiotics

  2006

  Nature Chemical Biology · 585 Zitationen · DOI

• Redox-Active Antibiotics Control Gene Expression and Community Behavior in Divergent Bacteria

  2008

  Science · 448 Zitationen · DOI

  It is thought that bacteria excrete redox-active pigments as antibiotics to inhibit competitors. In Pseudomonas aeruginosa, the endogenous antibiotic pyocyanin activates SoxR, a transcription factor conserved in Proteo- and Actinobacteria. In Escherichia coli, SoxR regulates the superoxide stress response. Bioinformatic analysis coupled with gene expression studies in P. aeruginosa and Streptomyces coelicolor revealed that the majority of SoxR regulons in bacteria lack the genes required for stress responses, despite the fact that many of these organisms still produce redox-active small molecules, which indicates that redox-active pigments play a role independent of oxidative stress. These compounds had profound effects on the structural organization of colony biofilms in both P. aeruginosa and S. coelicolor, which shows that "secondary metabolites" play important conserved roles in gene expression and development.

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