Prof. Dr. Tobias Krüger
Profil
Forschungsthemen15
AnthropoScenes. Making Sustainable Futures Public
Quelle ↗Förderer: Berlin University Alliance (BUA) Zeitraum: 07/2021 - 06/2024 Projektleitung: Prof. Dr. Jörg Niewöhner, Prof. Dr. Tobias Krüger, Prof. Dr. Klaus Eisenack, Prof. Dr. Peter H. Feindt
Eine Ethnographie sozial-ökologischen Modellierens: Materialität, Differenz und Komplexität situieren
Quelle ↗Förderer: DFG Sachbeihilfe Zeitraum: 06/2022 - 09/2023 Projektleitung: Prof. Dr. Tobias Krüger
Einstein Research Unit Climate and Water under Change, work package B4
Quelle ↗Förderer: ESB: Berlin University Alliance Zeitraum: 01/2022 - 12/2024 Projektleitung: Prof. Dr. Tobias Krüger
Einstein Research Unit Climate and Water under Change, work packages C1 and C3
Quelle ↗Förderer: ESB: Berlin University Alliance Zeitraum: 01/2022 - 12/2024 Projektleitung: Prof. Dr. Tobias Krüger
Geo.X: Socio-Hydrogeology (Phase 2)
Quelle ↗Förderer: Helmholtz-Gemeinschaft Zeitraum: 09/2019 - 08/2021 Projektleitung: Prof. Dr. Tobias Krüger
Gesundheitsrisiken für Frauen am Amazonas und die Anpassung von Flussgemeinden an trockenheitsbedingte Gefahren
Quelle ↗Förderer: Horizon Europe: Postdoctoral Fellowship EU (PF-EU) Zeitraum: 12/2025 - 11/2027 Projektleitung: Prof. Dr. Tobias Krüger
HGF: Geo.X: Who Benefits From Increased Water Storage? The Distribution of Social-Ecological Benefits of Sand Dams in Kenya (Phase 2)
Quelle ↗Förderer: Helmholtz-Gemeinschaft Zeitraum: 10/2019 - 09/2022 Projektleitung: Prof. Dr. Tobias Krüger
Navigating Colombian rivers with WhatsApp: Transdisciplinary mobile content campaign for and with riverine leaders on the water-energy-food nexus in the Magdalena-Cauca Basin
Quelle ↗Förderer: Volkswagen Stiftung Zeitraum: 10/2025 - 09/2026 Projektleitung: Prof. Dr. Tobias Krüger
Networking the diversity of interdisciplinary water research across the natural and social sciences, arts and humanities and with civil society
Quelle ↗Förderer: Fritz Thyssen Stiftung Zeitraum: 03/2025 - 04/2026 Projektleitung: Prof. Dr. Tobias Krüger
Postdoc Academy: Leadership for an Anthropocene world (LEAD)
Quelle ↗Förderer: Robert-Bosch-Stiftung Zeitraum: 10/2021 - 12/2023 Projektleitung: Prof. Dr. Tobias Krüger
Sommerschule "Situating Hydrological Modelling"
Quelle ↗Förderer: Volkswagen Stiftung Zeitraum: 03/2023 - 03/2024 Projektleitung: Prof. Dr. Tobias Krüger
VA: Summer School 2019 – Transformative Human Environment Research: Participatory Methods
Quelle ↗Förderer: DAAD Zeitraum: 01/2019 - 12/2019 Projektleitung: Prof. Dr. Tobias Krüger, Dr. Axel Klie
Vorbereitender Workshop für beantragtes Projekt: "Water security for whom? - Social and meaterial perspectives on inequality around multipurpose reservoirs in Colombia"
Quelle ↗Förderer: Volkswagen Stiftung Zeitraum: 03/2019 - 06/2019 Projektleitung: Prof. Dr. Tobias Krüger
Water4All - Kooperationsprojekt DEMOTAPE: Design multidimensionaler Wissensprotokolle zur Transformations grenzüberschreitender politischer Entscheidungen im Umgang mit hydoklimatischen Extremen
Quelle ↗Förderer: Bundesministerium für Forschung, Technologie und Raumfahrt Zeitraum: 04/2024 - 03/2027 Projektleitung: Prof. Dr. Tobias Krüger
Water Security for Whom? – Social and Material Perspectives on Inequality around Multipurpose Reservoirs in Colombia
Quelle ↗Förderer: Volkswagen Stiftung Zeitraum: 06/2020 - 12/2025 Projektleitung: Prof. Dr. Tobias Krüger, Prof. Dr. Jörg Niewöhner
Mögliche Industrie-Partner10
Stand: 26.4.2026, 19:48:44 (Top-K=20, Min-Cosine=0.4)
- 5 Treffer58.1%
- Gamification for Climate ActionP58.1%
- Gamification for Climate Action
- 15 Treffer57.4%
- Zuwendung im Rahmen des Programms „exist – Existenzgründungen aus der Wissenschaft“ aus dem Bundeshaushalt, Einzelplan 09, Kapitel 02, Titel 68607, Haushaltsjahr 2026, sowie aus Mitteln des Europäischen Strukturfonds (hier Euro-päischer Sozialfonds Plus – ESF Plus) Förderperiode 2021-2027 – Kofinanzierung für das Vorhaben: „exist Women“T57.4%
- Zuwendung im Rahmen des Programms „exist – Existenzgründungen aus der Wissenschaft“ aus dem Bundeshaushalt, Einzelplan 09, Kapitel 02, Titel 68607, Haushaltsjahr 2026, sowie aus Mitteln des Europäischen Strukturfonds (hier Euro-päischer Sozialfonds Plus – ESF Plus) Förderperiode 2021-2027 – Kofinanzierung für das Vorhaben: „exist Women“
- 7 Treffer56.2%
- The Pathway to Inquiry Based Science TeachingP56.2%
- The Pathway to Inquiry Based Science Teaching
- 7 Treffer56.2%
- The Pathway to Inquiry Based Science TeachingP56.2%
- The Pathway to Inquiry Based Science Teaching
- 7 Treffer56.2%
- The Pathway to Inquiry Based Science TeachingP56.2%
- The Pathway to Inquiry Based Science Teaching
- 7 Treffer56.2%
- The Pathway to Inquiry Based Science TeachingP56.2%
- The Pathway to Inquiry Based Science Teaching
- 7 Treffer56.2%
- The Pathway to Inquiry Based Science TeachingP56.2%
- The Pathway to Inquiry Based Science Teaching
- 5 Treffer53.0%
- NaturaConnect - Entwurf eines resilienten, kohärenten transeuropäischen Netzwerkes für Natur und MenschenT53.0%
- NaturaConnect - Entwurf eines resilienten, kohärenten transeuropäischen Netzwerkes für Natur und Menschen
- NaturaConnect - Entwurf eines resilienten, kohärenten transeuropäischen Netzwerkes für Natur und MenschenT53.0%
- NaturaConnect - Entwurf eines resilienten, kohärenten transeuropäischen Netzwerkes für Natur und Menschen
- 6 Treffer53.0%
- NaturaConnect - Entwurf eines resilienten, kohärenten transeuropäischen Netzwerkes für Natur und MenschenT53.0%
- NaturaConnect - Entwurf eines resilienten, kohärenten transeuropäischen Netzwerkes für Natur und Menschen
Publikationen25
Top 25 nach Zitationen — Quelle: OpenAlex (BAAI/bge-m3 embedded für Matching).
Green Chemistry · 68 Zitationen · DOI
Binary solvent mixtures with a suitable polarity and viscosity profile are viable green alternatives to DMF in solid-phase peptide synthesis.
Green Chemistry · 61 Zitationen · DOI
The composition of green binary solvent mixtures is used as a tool to mitigate side-reactions in SPPS.
Acta Orthopaedica · 54 Zitationen · DOI
CRP is a predictable and responsive serum parameter in postoperative monitoring of inflammatory responses in patients undergoing spine surgery, whereas WBC kinetics is unspecific. We suggest that CRP could be measured on the day before surgery, on day 2 or 3 after surgery, and also between days 4 and 6, to aid in early detection of infectious complications.
Biological Chemistry · 41 Zitationen · DOI
Site-specific bioconjugation strategies offer many possibilities for directed protein modifications. Among the various enzyme-based conjugation protocols, formylglycine-generating enzymes allow to posttranslationally introduce the amino acid Cα-formylglycine (FGly) into recombinant proteins, starting from cysteine or serine residues within distinct consensus motifs. The aldehyde-bearing FGly-residue displays orthogonal reactivity to all other natural amino acids and can, therefore, be used for site-specific labeling reactions on protein scaffolds. In this review, the state of research on catalytic mechanisms and consensus motifs of different formylglycine-generating enzymes, as well as labeling strategies and applications of FGly-based bioconjugations are presented.
Angewandte Chemie International Edition · 30 Zitationen · DOI
Formylglycine-generating enzymes are of increasing interest in the field of bioconjugation chemistry. They catalyze the site-specific oxidation of a cysteine residue to the aldehyde-containing amino acid C<sup>α</sup> -formylglycine (FGly). This non-canonical residue can be generated within any desired target protein and can subsequently be used for bioorthogonal conjugation reactions. The prototypic formylglycine-generating enzyme (FGE) and the iron-sulfur protein AtsB display slight variations in their recognition sequences. We designed specific tags in peptides and proteins that were selectively converted by the different enzymes. Combination of the different tag motifs within a single peptide or recombinant protein enabled the independent and consecutive introduction of two formylglycine residues and the generation of heterobifunctionalized protein conjugates.
The Thoracic and Cardiovascular Surgeon · 28 Zitationen · DOI
Surgery on ECC for T4 NSCLC gives satisfactory results. The site of infiltration appears to be most important for local tumor relapse. Long-term survival is possible in some cases. Simultaneous cardiac and pulmonary surgery resulted in good early and midterm outcomes without surgery-induced tumor propagation.
Applied Microbiology and Biotechnology · 27 Zitationen · DOI
Meerfahrten
201827 Zitationen · DOI
Das Meer entzieht sich der theoretischen Anschauung. Als das Unberechenbare und Gestaltlose schlechthin wirft es den Reisenden stets auf die individuelle Bewältigung der Naturgewalten zurück. Die Überlieferung von Weltneugierde und Abenteuerlust vollzieht sich im Medium des Reiseberichtes zwischen Vorgängern und Nachfahren: Bewahrt das Weltbild seinen Bezug zur Lebenswelt allein durch die stets neuerliche Konfrontation mit der Elementarnatur, so erhält der schiere existentielle Ernst sein bewegendes Pathos erst aus der verklärenden Perspektive einer ästhetischen Darstellung. Die Untersuchung skizziert eine Poetologie des Abenteuers, welche das Erleben und Überliefern von Alterität gleichermaßen als epistemologisch-sprachanalytisches wie ethisch-existentielles Dilemma identifiziert. Sieben textkritische Analysen verfolgen den Topos der Meerfahrt vom Spätmittelalter bis in die Postmoderne.
Bioconjugate Chemistry · 25 Zitationen · DOI
Multiple, site-specific protein conjugation is increasingly attractive for the generation of antibody-drug conjugates (ADCs). As it is important to control the number and position of cargoes in an ADC, position-selective generation of reactive sites in the protein of interest is required. Formylglycine (FGly) residues are generated by enzymatic conversion of cysteine residues embedded in a certain amino acid sequence motif with a formylglycine-generating enzyme (FGE). The addition of copper ions increases FGE activity leading to the conversion of cysteines within less readily accepted sequences. With this tuned enzyme activity, it is possible to address two different recognition sequences using two aerobic formylglycine-generating enzymes. We demonstrate an improved and facile strategy for the functionalization of a DARPin (designed ankyrin repeat protein) and the single-chain antibody scFv425-Fc, both directed against the epidermal growth factor receptor (EGFR). The single-chain antibody was conjugated with monomethyl auristatin E (MMAE) and carboxyfluorescein (CF) and successfully tested for receptor binding, internalization, and cytotoxicity in cell culture, respectively.
ChemBioChem · 20 Zitationen · DOI
Formylglycine-generating enzymes specifically oxidize cysteine within the consensus sequence CxPxR to C<sup>α</sup> -formylglycine (FGly). This noncanonical electrophilic amino acid can subsequently be addressed selectively by bioorthogonal hydrazino-iso-Pictet-Spengler (HIPS) or Knoevenagel ligation to attach payloads like fluorophores or drugs to proteins to obtain a defined payload-to-protein ratio. However, the disadvantages of these conjugation techniques include the need for a large excess of conjugation building block, comparably low reaction rates and limited stability of FGly-containing proteins. Therefore, functionalized clickable HIPS and tandem Knoevenagel building blocks were synthesized, conjugated to small proteins (DARPins) and subsequently linked to strained alkyne-containing payloads for protein labeling. This procedure allowed the selective bioconjugation of one or two DBCO-carrying payloads with nearly stoichiometric amounts at low concentrations. Furthermore, an azide-modified tandem Knoevenagel building block enabled the synthesis of branched PEG linkers and the conjugation of two fluorophores, resulting in an improved signal-to-noise ratio in live-cell fluorescence-imaging experiments targeting the EGF receptor.
ChemBioChem · 12 Zitationen · DOI
Formylglycine-generating enzymes provide a convenient tool for site-specific protein derivatization. Their ability to oxidize cysteine or serine residues within a defined consensus sequence to C<sup>α</sup> -formylglycine (FGly) allows for the targeted introduction of a unique chemical handle for various bioconjugation reactions. In recent years, oxygen-dependent FGly-generating enzyme saw broad use in protein functionalization and the generation of protein conjugates. Yet, the FGly-generating system AtsB, along with its capability to convert unusual aldehyde tag sequences, remains mostly unused. Herein, the ability of AtsB from Methanosarcina mazei to convert nonclassical aldehyde tags of the SX(A/P)XR-type and its potential use in bioconjugation chemistry are demonstrated.
Angewandte Chemie · 4 Zitationen · DOI
Abstract Formylglycin‐generierende Enzyme haben in den letzten Jahren breite Anwendung in der bioorthogonalen Chemie gefunden. Sie katalysieren die ortsspezifische Oxidation eines Cysteinrestes zur Aldehyd‐haltigen Aminosäure C α ‐Formylglycin (FGly). FGly kann in jedem beliebigen Zielprotein generiert und anschließend für bioorthogonale Konjugationsreaktionen genutzt werden. Das prototypische Formylglycin‐generierende Enzym (FGE) und das Eisen‐Schwefel‐Protein AtsB zeigen leichte Variationen in ihren Erkennungssequenzen. Spezifische Motive in Peptiden und Proteinen wurden entworfen, die selektiv von diesen Enzymen adressiert werden. Die Kombination dieser Motive innerhalb eines Peptids oder rekombinanten Proteins ermöglichte die unabhängige und sukzessive Einführung von zwei FGly‐Resten und die Generierung hetero‐difunktionalisierter Proteinkonjugate.
Qucosa (Saxon State and University Library Dresden) · 3 Zitationen
Der Beitrag stellt neue Indikatoren zur Analyse und zum Monitoring der Zerschneidung von Freiräumen sowie zur Fragmentierung von Wald- und Forstflächen vor, die bestehende bundesweite Indikatorensysteme ergänzen sollen. Die Ergebnisse werden beispielhaft auf der Ebene von Gemeinden, Kreisen und Raumordnungsregionen präsentiert. Sie zeigen u. a., dass es deutschlandweit nur noch ca. 140 zusammenhängende Wälder mit einer Größe von mehr als 50 km² gibt.
Naturschutz und Landschaftsplanung (NuL) · 1 Zitationen · DOI
Photovoltaik ist Teil der Strategie zur Gewinnung erneuerbarer Energien. Neben Dächern und Fassaden werden auch Freilandflächen zur Aufstellung von Photovoltaik-Freiflächenanlagen (PV-FFA) genutzt. Die Karte zeigt, wie hoch deren Flächenanteile in den
1 Zitationen · DOI
A modern in the current meaning scientific approach to the Findling phenomenon is ascertainable around 1740. The blocks of nonlocal types of rock, some weighing tons, scattered about the landscape were the point of departure for considerations that ultimately led to the discovery of the ice ages. This applied to the Alpine region as well as to the North German Lowlands. Initially, various rival theories sought to explain their origin: eruptions and mudflows; drift and glacial theories. By about 1800 all the approaches that scholars would be discussing in the following decades to explain the origin and distribution of Findlinge had been formulated in outline. Despite all the objections, the great deluge of mud and boulders was the dominant theory at the beginning of the 19th century. Nevertheless, the debate remained open.Keywords:drift theory; eratic blocks; eruption theory; glacial theory; ice ages; mudflow theory
0028-0615 · 1 Zitationen · DOI
Der vom Leibniz-Institut für ökologische Raumentwicklung betriebene Monitor zur Siedlungs- und Freiraumentwicklung (IÖR-Monitor) stellt deutschlandweit Indikatoren zum Waldanteil und zur Waldfragmentierung online bereit. Hintergrund ist die hohe Bedeutung
Abstract. Global statistical irrigation modeling relies on geospatial data and traditionally adopts a discrete global grid based on longitude-latitude reference. However, this system introduces area distortion, which may lead to biased results. We propose using the ISEA3H geodesic grid based on hexagonal cells, enabling efficient and distortion-free representation of spherical data. To understand the impact of discrete global grid choice, we employ a non-parametric statistical framework, utilizing random forest methods, to identify main drivers of historical global irrigation expansion amongst others, also using outputs from the global dynamic vegetation model LPJmL. Irrigation is critical for food security amidst growing population, changing consumption patterns, and climate change. It significantly boosts crop yields but also alters the natural water cycle and global water resources. Understanding past irrigation expansion and its drivers is vital for global change research, resource assessment, and predicting future trends. We compare the predictive accuracy, the simulated irrigation patterns and identification of irrigation drivers between the two grid choices. Results demonstrate that using the ISEA3H geodesic grid increases the predictive accuracy by 29 % compared to the longitude-latitude grid. The model identifies population density, potential productivity increase, evaporation, precipitation, and water discharge as key drivers of historical global irrigation expansion. GDP per capita also shows minimal influence. We conclude that the geodesic discrete global grid significantly affects predicted irrigation patterns and identification of drivers, and thus has the potential to enhance statistical modeling, which warrants further exploration in future research across related fields. This analysis lays the foundation for comprehending historical global irrigation expansion.
The Thoracic and Cardiovascular Surgeon · DOI
Background: Analyses from GERAADA provided data for perioperative neurologic dysfunction, which was shown to be associated with an increased mortality. GERAADA long-term follow-up investigates the neurologic outcomes over a 16-year timeframe to determine whether AADA patients are at risk for secondary neurologic complications.
The ecosystem function of vegetation to attenuate riverine export of nutrients is of substantial importance for securing water quality. This ecosystem function is at risk of deterioration due to an increasing risk of large-scale forest dieback under climate change. The present study explores the response of the nitrogen (N) cycle of a forest catchment in the Bavarian Forest National Park, Germany, in the face of a severe bark beetle () outbreak and resulting large-scale forest dieback. Outbreaks of bark beetle killed the dominant tree species Norway spruce () in up to 55 % of the area. A Bayesian hierarchical model that predicts stream NO concentration (C) with discharge (Q) and water temperature (T) as predictors (C-Q-T relationship) was found as the best fitting model. This informed top-down development of a catchment model to explain the C-Q-T relationship so that the annually-varying model parameter estimates provide mechanistic interpretations of the catchment processes. NO concentration increased after the dieback because N was released from the decaying fine litter of trees beyond the capacity of the terrestrial vegetation and riparian zone to regulate the nutrient export. Within a decade after the dieback, the released N was flushed out and nutrient retention capacity was restored with the regrowth of the vegetation. Greater understanding of canopy mortality due to climate change and other anthropogenic impacts are required to mitigate the deterioration of nutrient retention and prevent nutrient loss.
The Thoracic and Cardiovascular Surgeon · DOI
Objectives: Endothelial progenitor cells (EPCs) are the stem cells in the adult human body which enable the neovascularization of ischemic tissues. However, the low number and homing capacity of EPCs hamper the successful application of these cells. Thus, we delivered synthetic mRNAs encoding proangiogenic factors into mouse EPCs and examined the influence on angiogenic potential of EPCs.
Qucosa (Saxon State and University Library Dresden)
Flächenbezogene Indikatoren für eine nachhaltige bauliche Entwicklung sind zum einen die Zunahme der Bodenversiegelung, die Flächenneuinanspruchnahme für Siedlung und Verkehr sowie die Überbauung innerhalb baulich geprägter Flächen. Zielsetzungen zur flächensparenden Siedlungstätigkeit werden auf Bundes- oder Landesebene politisch fixiert, müssen jedoch auf lokaler Planungsebene umgesetzt werden. Das bedeutet Veränderung der Siedlungsstruktur aus lokal begrenzter Sicht. Eine Bilanzierung von Änderungen kann erst im Zuge landes- oder bundesweiter Erhebungen erfolgen, etwa der statistischen Flächenerhebung nach Art der tatsächlichen Nutzung oder eines geodatenbasierten Monitorings (wie z. B. dem IÖR-Monitor). Der Beitrag stellt aktuelle Analyseergebnisse aus dem IÖR-Monitor dar und untersucht, inwieweit sich bauliche Dichten bzw. Überbauungsgrade im Bestand sowie in neuen Siedlungsflächen baulicher Prägung entwickelt haben.
Kooperationen11
Bestätigte Forscher↔Partner-Paare aus HU-FIS — Gold-Standard-Positive für das Matching.
Einstein Research Unit Climate and Water under Change, work packages C1 and C3
university
Postdoc Academy: Leadership for an Anthropocene world (LEAD)
other
Einstein Research Unit Climate and Water under Change, work packages C1 and C3
university
HGF: Geo.X: Who Benefits From Increased Water Storage? The Distribution of Social-Ecological Benefits of Sand Dams in Kenya (Phase 2)
other
Networking the diversity of interdisciplinary water research across the natural and social sciences, arts and humanities and with civil society
other
Water4All - Kooperationsprojekt DEMOTAPE: Design multidimensionaler Wissensprotokolle zur Transformations grenzüberschreitender politischer Entscheidungen im Umgang mit hydoklimatischen Extremen
university
Postdoc Academy: Leadership for an Anthropocene world (LEAD)
university
Water Security for Whom? – Social and Material Perspectives on Inequality around Multipurpose Reservoirs in Colombia
university
Postdoc Academy: Leadership for an Anthropocene world (LEAD)
university
Einstein Research Unit Climate and Water under Change, work package B4
university
Water Security for Whom? – Social and Material Perspectives on Inequality around Multipurpose Reservoirs in Colombia
university
Stammdaten
Identität, Organisation und Kontakt aus HU-FIS.
- Name
- Prof. Dr. Tobias Krüger
- Titel
- Prof. Dr.
- Fakultät
- Mathematisch-Naturwissenschaftliche Fakultät
- Institut
- Geographisches Institut
- Arbeitsgruppe
- Hydrologie und Gesellschaft
- Telefon
- +49 30 2093-6839
- HU-FIS-Profil
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- 26.4.2026, 01:08:05